Cyclic AMP‐mediated regulation of vascular smooth muscle cell cyclic AMP phosphodiesterase activity

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

International Union of Pharmacology nomenclature of adrenoceptors.

1994 • 1,173 citations

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

1990 • 860 citations

Complexity and Diversity of Mammalian Adenylyl Cyclases

1996 • 857 citations

Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase

1996 • 406 citations

Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP.

1990 • 354 citations

Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta

1986 • 301 citations

A Family of Human Phosphodiesterases Homologous to the Dunce Learning and Memory Gene Product of Drosophila melanogaster are Potential Targets for Antidepressant Drugs

1993 • 287 citations

Cyclic GMP and mechanisms of vasodilation

1989 • 260 citations

Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets

1986 • 249 citations

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

1993 • 233 citations

Nitric Oxide and Cyclic GMP Signaling

1996 • 228 citations

The short-term activation of a rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation.

1994 • 183 citations

Cyclic nucleotide phosphodiesterases: Structure, regulation and drug action

1991 • 176 citations

Cyclic AMP and mechanisms of vasolidation

1990 • 172 citations

The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP.

1989 • 142 citations

Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE 3 gene family)

1995 • 127 citations

Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3.

1995 • 127 citations

Stimulation of beta adrenoceptors in a human monocyte cell line (U937) up-regulates cyclic AMP-specific phosphodiesterase activity.

1992 • 124 citations

Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells.

1995 • 118 citations

Purification and characterization of a human platelet cyclic nucleotide phosphodiesterase

1984 • 115 citations

Role of cyclic AMP- and cyclic GMP-phosphodiesterases in the control of cyclic nucleotide levels and smooth muscle tone in rat isolated aorta

1987 • 99 citations

Salbutamol Up-regulates PDE4 Activity and Induces a Heterologous Desensitization of U937 Cells to Prostaglandin E2

1995 • 92 citations

Effects of cyclic GMP elevation on isoprenaline‐induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3

1996 • 89 citations

Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B.

1996 • 85 citations

Synergistic actions of nitrovasodilators and isoprenaline on rat aortic smooth muscle

1991 • 83 citations

Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits cAMP accumulation in human platelets: effects on platelet aggregation

1997 • 82 citations

cAMP-mediated phosphorylation of the low-Km cAMP phosphodiesterase markedly stimulates its catalytic activity.

1988 • 80 citations

Hormone-sensitive particulate cAMP phosphodiesterase activity in 3T3-L1 adipocytes. Regulation of responsiveness by dexamethasone.

1983 • 71 citations

Nitroprusside enhances isoprenaline-induced increases in cAMP in rat aortic smooth muscle

1990 • 69 citations

Identification of the Site in the cGMP-inhibited Phosphodiesterase Phosphorylated in Adipocytes in Response to Insulin and Isoproterenol

1996 • 60 citations

Mechanisms of Ligand-Induced Desensitization of Beta-Adrenergic Receptors

1991 • 39 citations

Desensitization of β-adrenergic responses in adipocytes involves receptor subtypes and cAMP phosphodiesterase

1995 • 21 citations

Cultured smooth muscle approach in the study of hypertension

1992 • 15 citations

Measurement of both Cyclic [3H]AMP and Cyclic [3H]GMP in Cultured Vascular Smooth Muscle Cells Labeled with [3H]Hypoxanthine: Use in Studies of Cardiovascular Drugs

1993 • 13 citations

Cell layer-specific expression of cyclic nucleotide phosphodiesterases in rat arteries: Molecular cloning using isolated cell layers from paraformaldehyde-fixed tissues

1995 • 5 citations