Characterization of the Rolipram-Sensitive, Cyclic AMP-Specific Phosphodiesterases: Identification and Differential Expression of Immunologically Distinct Forms in the Rat Brain

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Multiple cyclic nucleotide phosphodiesterase activities from rat brain

1971 • 1,054 citations

Transformation of rat cells by DNA of human adenovirus 5

1973 • 664 citations

Characterization of Several Clonal Lines of Cultured Ley dig Tumor Cells: Gonadotropin Receptors and Steroidogenic Responses*

1981 • 596 citations

Core filaments of the nuclear matrix.

1990 • 436 citations

Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase

1996 • 406 citations

Recent Progress in Understanding the Hormonal Regulation of Phosphodiesterases

1995 • 313 citations

A Family of Human Phosphodiesterases Homologous to the Dunce Learning and Memory Gene Product of Drosophila melanogaster are Potential Targets for Antidepressant Drugs

1993 • 287 citations

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

1993 • 233 citations

Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase.

1989 • 192 citations

Versatile expression vectors for high-level synthesis of cloned gene products in Escherichia coli

1985 • 174 citations

Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes.

1989 • 171 citations

Hormonal Regulation of Cyclic Nucleotide Phosphodiesterases*

1991 • 153 citations

Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.

1989 • 147 citations

Phosphorylation results in activation of a cAMP phosphodiesterase in human platelets.

1988 • 146 citations

Expression and regulation of human and rat phosphodiesterase type IV isogenes

1994 • 139 citations

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

1993 • 133 citations

Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase.

1990 • 133 citations

The ratPDE3/IVd phosphodiesterase gene codes for multiple proteins differentially activated by cAMP-dependent protein kinase

1994 • 132 citations

Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from the rat Sertoli cell.

1991 • 130 citations

Stimulation of beta adrenoceptors in a human monocyte cell line (U937) up-regulates cyclic AMP-specific phosphodiesterase activity.

1992 • 124 citations

Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells.

1995 • 118 citations

Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

1995 • 113 citations

Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases

1994 • 108 citations

Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum

1995 • 93 citations

Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases. Multiple mRNA variants originate from alternative splicing and multiple start sites.

1994 • 92 citations

Identification of two splice variant forms of type-IVB cyclic AMP phosphodiesterase, DPD (rPDE-IVB1) and PDE-4 (rPDE-IVB2) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regions

1994 • 88 citations

The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family

1993 • 75 citations

Regulation by Follicle-Stimulating Hormone and Dibutyryl Adenosine 3′,5′-Monophosphate of a Phosphodiesterase Isoenzyme of the Sertoli Cell*

1982 • 68 citations

Brain distribution of four rat homologues of the drosophila dunce cAMP phosphodiesterase

1995 • 61 citations

Expression of a kinase anchor protein 75 depletes type II cAMP-dependent protein kinases from the cytoplasm and sequesters the kinases in a particulate pool.

1993 • 59 citations

Characterization of a hormone-inducible, high affinity adenosine 3',5'-cyclic monophosphate phosphodiesterase from the rat Sertoli cell

1995 • 57 citations

A mouse homolog of dunce, a gene important for learning and memory in drosophila, is preferentially expressed in olfactory receptor neurons

1995 • 50 citations

Unique Adenosine 3′,5′ Cyclic Monophosphate Phosphodiesterase Messenger Ribonucleic Acids in Rat Spermatogenic Cells: Evidence for Differential Gene Expression during Spermatogenesis1

1992 • 34 citations

Differential distribution of mRNA encoding cAMP-specific phosphodiesterase isoforms in the rat brain

1996 • 23 citations

The N-terminal alternately spliced regions of PDE4A cAMP-specific phosphodiesterases determine intracellular targeting and regulation of catalytic activity

1996 • 22 citations

Molecular Properties of Cyclic Nucleotide Phosphodiesterase Isozymes

1989 • 7 citations