Phosphodiesterases 4 Inhibitors

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Phosphodiesterase Isozymes

1998 • 655 citations

Tumour necrosis factor and Crohn's disease.

1997 • 504 citations

Phosphodiesterase inhibitors: new opportunities for the treatment of asthma.

1991 • 383 citations

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

1995 • 345 citations

Taming TNF: strategies to restrain this proinflammatory cytokine

1997 • 287 citations

Stereospecific binding of the antidepressant rolipram to brain protein structures

1986 • 235 citations

Proposal for Pharmacologically Distinct Conformers of PDE4 Cyclic AMP Phosphodiesterases

1997 • 185 citations

Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production

1998 • 185 citations

Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor.

1995 • 178 citations

Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst1

1990 • 176 citations

Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition

1996 • 161 citations

Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan‐stimulated respiratory burst by ‘type IV’‐selective PDE inhibitors

1991 • 148 citations

Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.

1989 • 147 citations

1,4-Cyclohexanecarboxylates: Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma

1998 • 146 citations

Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast.

1992 • 139 citations

Expression and regulation of human and rat phosphodiesterase type IV isogenes

1994 • 139 citations

Characterization of cAMP-dependent inhibition of LPS-induced TNFα production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor

1994 • 136 citations

SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions.

1998 • 135 citations

Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: A diverse family of regulatory enzymes

1994 • 135 citations

Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from the rat Sertoli cell.

1991 • 130 citations

Anti-inflammatory activity of phosphodiesterase (PDE)-IV inhibitors in acute and chronic models of inflammation

1995 • 126 citations

Expression, Purification, and Characterization of Human cAMP-Specific Phosphodiesterase (PDE4) Subtypes A, B, C, and D

1997 • 122 citations

Mapping the functional domains of human recombinant phosphodiesterase 4A: structural requirements for catalytic activity and rolipram binding.

1996 • 114 citations

Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer

1996 • 113 citations

Effects of rolipram on responses to acute and chronic antigen exposure in monkeys.

1994 • 101 citations

Could isoenzyme-selective phosphodiesterase inhibitors render bronchodilator therapy redundant in the treatment of bronchial asthma?

1992 • 97 citations

Emetic, central nervous system and pulmonary activities of rolipram in the dog

1995 • 93 citations

Treatment with tumour necrosis factor inhibitor oxpentifylline does not improve corticosteroid dependent chronic active Crohn's disease.

1997 • 92 citations

Preliminary identification and role of phosphodiesterase isozymes in human basophils.

1992 • 83 citations

In vitro effects of oxpentifylline on inflammatory cytokine release in patients with inflammatory bowel disease.

1997 • 78 citations

Therapeutic potential of phosphodiesterase type 4 inhibition in chronic autoimmune demyelinating disease

1997 • 77 citations

Molecular cloning and functional expression in yeast of a human cAMP‐specific phosphodiesterase subtype (PDE IV‐C)

1995 • 74 citations

Novel Heterocyclic-Fused Pyridazinones as Potent and Selective Phosphodiesterase IV Inhibitors

1997 • 71 citations

Human Recombinant Phosphodiesterase 4B2B Binds (R)-Rolipram at a Single Site with Two Affinities

1997 • 67 citations

Protection from T cell-mediated murine liver failure by phosphodiesterase inhibitors.

1997 • 67 citations

Modulation of TNFα and IL-1β from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors

1993 • 66 citations

Preventive but not therapeutic application of Rolipram ameliorates experimental autoimmune encephalomyelitis in Lewis rats

1996 • 64 citations

Zinc Dependent Activation of cAMP-Specific Phosphodiesterase (PDE4A)

1997 • 62 citations

Amelioration of collagen II-induced arthritis in rats by the type IV phosphodiesterase inhibitor Rolipram

1997 • 61 citations

The specific type III and IV phosphodiesterase inhibitor zardaverine suppresses formation of tumor necrosis factor by macrophages

1993 • 61 citations

Influence of isoproterenol and phosphodiesterase inhibitors on platelet-activating factor biosynthesis in the human neutrophil.

1993 • 60 citations

Phosphodiesterase inhibition improves agonist-induced relaxation of hypertensive pulmonary arteries.

1997 • 57 citations

Striking Effect of Hydroxamic Acid Substitution on the Phosphodiesterase Type 4 (PDE4) and TNFα Inhibitory Activity of Two Series of Rolipram Analogues: Implications for a New Active Site Model of PDE4

1998 • 54 citations

In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633.

1996 • 52 citations

Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse

1994 • 48 citations

PDE 4 inhibitors: the use of molecular cloning in the design and development of novel drugs

1997 • 48 citations

Influence of pentoxifylline on cytokine levels and inflammatory parameters in septic shock

1996 • 46 citations

Detailed Characterization of a Purified Type 4 Phosphodiesterase, HSPDE4B2B: Differentiation of High- and Low-Affinity (R)-Rolipram Binding

1997 • 45 citations

Reduction of bone loss by denbufylline, an inhibitor of phosphodiesterase 4

1997 • 43 citations

9-Benzyladenines: Potent and Selective cAMP Phosphodiesterase Inhibitors

1997 • 42 citations

Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19

1995 • 42 citations

Differential effect of phosphodiesterase 4 inhibitors on the proliferation of human peripheral blood mononuclear cells from normals and subjects with atopic dermatitis

1995 • 39 citations

Inhibition of eotaxin‐mediated human eosinophil activation and migration by the selective cyclic nucleotide phosphodiesterase type 4 inhibitor rolipram

1997 • 38 citations

Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4

1995 • 38 citations

The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy.

1997 • 37 citations

Phosphodiesterase-IV inhibition, respiratory muscle relaxation and bronchodilation by WAY-PDA-641.

1994 • 30 citations

The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4.

1996 • 29 citations

The influence of endogenous catecholamines on the inhibitory effects of rolipram against early- and late-phase response to antigen in the guinea pig.

1997 • 27 citations

Role of Conserved Histidines in Catalytic Activity and Inhibitor Binding of Human Recombinant Phosphodiesterase 4A

1997 • 27 citations

Effects of RP 73401, a novel, potent and selective phosphodiesterase type 4 inhibitor, on contractility of human, isolated bronchial muscle

1996 • 26 citations

In vitro down-regulation of antigen-induced IL-5 gene expression and protein production by cAMP-specific phosphodiesterase type 4 inhibitor.

1996 • 25 citations

Selective Inhibitors of Cyclic AMP-Specific Phosphodiesterase: Heterocycle-Condensed Purines

1997 • 25 citations

The effects of anti-inflammatory and antiallergic drugs on the release of IL-1β and TNF-α in the human whole blood assay

1993 • 24 citations

Treatment with the type IV phosphodiesterase inhibitor Ro 20-1724 protects renal and mesenteric blood flow in endotoxemic rats treated with norepinephrine.

1996 • 23 citations

Phosphodiesterase type IV inhibitors in the treatment of multiple sclerosis

1997 • 22 citations

Interleukin-5 production by peripheral blood mononuclear cells of asthmatic patients is suppressed by T-440: relation to phosphodiesterase inhibition.

1996 • 22 citations

Anti-inflammatory and bronchodilator properties of KF19514, a phosphodiesterase 4 and 1 inhibitor

1997 • 20 citations

Cyclic AMP-Elevating Agents Inhibit Mite-Antigen-Induced IL-4 and IL-13 Release from Basophil-Enriched Leukocyte Preparation

1997 • 19 citations

Suppression of experimental autoimmune neuritis by phosphodiesterase inhibitor pentoxifylline

1996 • 19 citations

Advances in the understanding and treatment of atopic dermatitis

1997 • 13 citations

A Pharmacophore Model for PDE IV Inhibitors

1997 • 12 citations

Inhibition of lipopolysaccharide-induced bowel erythrocyte extravasation in rats, and of mesenteric hypoperfusion in dogs, by phosphodiesterase inhibitors

1996 • 12 citations

Inhibitory Effect of a Novel Phosphodiesterase IV Inhibitor, T-440, on Antigen- and Chemical Mediator-Induced Bronchoconstrictions in Guinea Pigs In Vivo

1996 • 10 citations

Biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-α

1997 • 10 citations

Effect of T-440, a Novel Type IV Phosphodiesterase Inhibitor, on Allergen-Induced Immediate and Late Asthmatic Reaction and Leukocyte Infiltration into the Airways of Guinea Pigs

1997 • 9 citations

Pulmonary antiallergic and antiinflammatory effects of a novel, orallyactive phosphodiesterase IV inhibitor (WAY-127093B) in guinea pigs and rats

1995 • 7 citations

A Novel Phosphodiesterase Inhibitor, T-440: Possible Management of Eosinophilic Inflammation by Down-Regulation of lnterleukin-5 Production

1996 • 6 citations

KF19514, a Phosphodiesterase 4 and 1 Inhibitor, Inhibits PAF-lnduced Lung Inflammatory Responses by Inhaled Administration in Guinea Pigs

1997 • 6 citations

Bronchoprotective effects of KF-19514 and cilostazol in guinea pigs in vivo

1997 • 6 citations

Differential in vivo and in vitro bronchorelaxant activities of CP-80,633, a selective phosphodiesterase 4 inhibitor

1997 • 5 citations

T-440

1997 • 3 citations