von Willebrand Disease

Initiation of Platelet Adhesion by Arrest onto Fibrinogen or Translocation on von Willebrand Factor

1996 • 1,178 citations

Characterization of the human factor VIII gene

1984 • 983 citations

Epidemiological investigation of the prevalence of von Willebrand's disease

1987 • 956 citations

Molecular cloning of a cDNA encoding human antihaemophilic factor

1984 • 937 citations

The effect of ABO blood group on the diagnosis of von Willebrand disease

1987 • 898 citations

Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis

1996 • 893 citations

Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion

1996 • 785 citations

Immunologic differentiation of classic hemophilia (factor VIII deficiency) and von Willebrand's disease

1971 • 660 citations

Cell Biology of von Willebrand Factor

1990 • 604 citations

1-DEAMINO-8-D-ARGININE VASOPRESSIN: A NEW PHARMACOLOGICAL APPROACH TO THE MANAGEMENT OF HAEMOPHILIA AND VON WILLEBRAND'S DISEASE

1977 • 597 citations

Why low molecular weight heparin?

1990 • 596 citations

A Revised Classification of von Willebrand Disease

1994 • 595 citations

A Critical Reappraisal of the Bleeding Time*

1990 • 571 citations

The Bleeding Time as a Screening Test for Evaluation of Platelet Function

1972 • 571 citations

Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes

1995 • 538 citations

Variant von Willebrand's Disease

1980 • 516 citations

Structure of the gene for human von Willebrand factor

1989 • 497 citations

Amino acid sequence of human von Willebrand factor

1986 • 486 citations

Prevalence of von Willebrand disease in children: A multiethnic study

1993 • 454 citations

von Willebrand factor and von Willebrand disease [published erratum appears in Blood 1988 Mar;71(3):830]

1987 • 435 citations

Quantitative Assay of a Plasma Factor Deficient in von Willebrand's Disease that is Necessary for Platelet Aggregation. RELATIONSHIP TO FACTOR VIII PROCOAGULANT ACTIVITY AND ANTIGEN CONTENT

1973 • 421 citations

Human von Willebrand Factor (vWF): Isolation of Complementary DNA (cDNA) Clones and Chromosomal Localization

1985 • 420 citations

Synthesis of Factor VIII Antigen by Cultured Guinea Pig Megakaryocytes

1977 • 390 citations

Heightened Interaction between Platelets and Factor VIII/von Willebrand Factor in a New Subtype of von Willebrand's Disease

1980 • 381 citations

Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear rate--dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier syndrome.

1978 • 368 citations

DIABETIC KETOACIDOSIS

1974 • 363 citations

Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor.

1990 • 347 citations

von Willebrand factor and von Willebrand disease [published erratum appears in Blood 1988 Mar;71(3):830]

1987 • 311 citations

Cloning and characterization of two cDNAs coding for human von Willebrand factor.

1985 • 302 citations

Induction of specific storage organelles by von Willebrand factor propolypeptide

1991 • 276 citations

Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets

1993 • 271 citations

Biosynthesis of von Willebrand protein by human megakaryocytes.

1985 • 271 citations

A major factor VIII binding domain resides within the amino-terminal 272 amino acid residues of von Willebrand factor.

1987 • 263 citations

Platelet Aggregation Induced by I-Desamino-8-D-Arginine Vasopressin (dDAVP) in Type IIb von Willebrand's Disease

1983 • 260 citations

Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand's disease the link?

1992 • 260 citations

Full-length von Willebrand factor (vWF) cDNA encodes a highly repetitive protein considerably larger than the mature vWF subunit.

1986 • 260 citations

Inactivation of human factor VIII by activated protein C. Cofactor activity of protein S and protective effect of von Willebrand factor.

1988 • 244 citations

Human von Willebrand factor gene and pseudogene: structural analysis and differentiation by polymerase chain reaction

1991 • 235 citations

New variant of von Willebrand disease with defective binding to factor VIII

1989 • 234 citations

Impaired intracellular transport produced by a subset of type IIA von Willebrand disease mutations.

1992 • 230 citations

Defective Ristocetin-Induced Platelet Aggregation in von Willebrand's Disease and its Correction by Factor VIII

1973 • 222 citations

Pseudo-von Willebrand's Disease

1982 • 219 citations

Isolation and Characterization of Human Factor VIII (Antihemophilic Factor)

1973 • 216 citations

Von Willebrand Disease: A Database of Point Mutations, Insertions, and Deletions

1993 • 215 citations

v. Willebrand's Disease and its Correction with Human Plasma Fraction 1‐0

1957 • 215 citations

Structure of pre-pro-von Willebrand factor and its expression in heterologous cells

1986 • 212 citations

Structure of the von Willebrand factor domain interacting with glycoprotein Ib.

1988 • 208 citations

Gene deletions in patients with haemophilia B and anti-factor IX antibodies

1983 • 207 citations

Platelet-type von Willebrand's disease: characterization of a new bleeding disorder

1982 • 197 citations

The propeptide of von Willebrand Factor independently mediates the assembly of von Willebrand multimers

1988 • 192 citations

The Thymus and Autoimmunity

1967 • 188 citations

Patterns of development of tachyphylaxis in patients with haemophilia and von Willebrand disease after repeated doses of desmopressin (DDAVP)

1992 • 187 citations

Heterogeneity of type I von Willebrand disease: evidence for a subgroup with an abnormal von Willebrand factor

1985 • 187 citations

v. Willebrand's Disease in Sweden.

1959 • 185 citations

Identification of a site in the alpha chain of platelet glycoprotein Ib that participates in von Willebrand factor binding.

1990 • 182 citations

von Willebrand's disease in Sweden.

1973 • 180 citations

Gene deletions correlate with the development of alloantibodies in von Willebrand disease.

1987 • 170 citations

Biosynthesis of von Willebrand protein by human endothelial cells. Identification of a large precursor polypeptide chain.

1983 • 166 citations

Response of Patients with Mild and Moderate Hemophilia A and von Willebrand's Disease to Treatment with Desmopressin

1985 • 166 citations

Molecular cloning of cDNA for human von willebrand factor: Authentication by a new method

1985 • 162 citations

Family studies and prenatal diagnosis in severe von Willebrand disease by polymerase chain reaction amplification of a variable number tandem repeat region of the von Willebrand factor gene

1990 • 160 citations

Propolypeptide of von Willebrand Factor Circulates in Blood and Is Identical to von Willebrand Antigen II

1986 • 160 citations

Interaction of the von Willebrand Factor (vWF) with Collagen

1995 • 160 citations

The role of von Willebrand factor multimers and propeptide cleavage in binding and stabilization of factor VIII.

1991 • 159 citations

Studies of the pathophysiology of acquired von Willebrand's disease in seven patients with lymphoproliferative disorders or benign monoclonal gammopathies

1984 • 158 citations

Construction of cDNA coding for human von Willebrand factor using antibody probes for colony-screening and mapping of the chromosomal gene

1985 • 157 citations

A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728.

1987 • 156 citations

Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease.

1991 • 155 citations

Serial studies in von Willebrand's disease: variability versus "variants"

1980 • 155 citations

A3 Domain Is Essential for Interaction of von Willebrand Factor with Collagen Type III

1996 • 154 citations

A new von Willebrand factor (vWF) defect in a patient with factor VIII (FVIII) deficiency but with normal levels and multimeric patterns of both plasma and platelet vWF. Characterization of abnormal vWF/FVIII interaction

1990 • 152 citations

Nucleotide sequence of pre-pro-von Willebrand factor cDNA

1986 • 152 citations

The Subunit Structure of Normal and Hemophilic Factor VIII

1973 • 151 citations

Isolation of the von Willebrand Factor Domain Interacting with Platelet Glycoprotein Ib, Heparin, and Collagen and Characterization of Its Three Distinct Functional Sites

1989 • 147 citations

Localization of binding sites within human von Willebrand factor for monomeric type III collagen

1986 • 145 citations

The affinity and stoichiometry of binding of human factor VIII to von Willebrand factor

1995 • 143 citations

Dominant type 1 von Willebrand disease caused by mutated cysteine residues in the D3 domain of von Willebrand factor

1996 • 139 citations

Aberrant multimeric structure of von Willebrand factor in a new variant of von Willebrand's disease (type IIC).

1982 • 136 citations

Identification of discontinuous von Willebrand factor sequences involved in complex formation with botrocetin. A model for the regulation of von Willebrand factor binding to platelet glycoprotein Ib.

1991 • 135 citations

Molecular basis of human von Willebrand disease: analysis of platelet von Willebrand factor mRNA.

1989 • 135 citations

Genetics of classic von Willebrand's disease. I. Phenotypic variation within families

1979 • 132 citations

HYPOTHYROIDISM AS A CAUSE OF ACQUIRED VON WDLLEBRAND'S DISEASE

1987 • 131 citations

Expression of variant von Willebrand factor (vWF) cDNA in heterologous cells: requirement of the pro-polypeptide in vWF multimer formation.

1987 • 127 citations

von Willebrand disease "Vicenza" with larger-than-normal (supranormal) von Willebrand factor multimers

1988 • 125 citations

Transfusion Studies in von Willebrand's Disease: Effect on Bleeding Time and Factor VIII

1963 • 124 citations

The molecular defect in type IIB von Willebrand disease. Identification of four potential missense mutations within the putative GpIb binding domain.

1991 • 120 citations

Recessive inheritance of von Willebrand's disease type I

1993 • 119 citations

Molecular basis of von Willebrand disease type IIB. Candidate mutations cluster in one disulfide loop between proposed platelet glycoprotein Ib binding sequences.

1991 • 117 citations

Nasal Spray Desmopressin (DDAVP) for Mild Hemophilia A and von Willebrand Disease

1991 • 115 citations

Comparison of four virus-inactivated plasma concentrates for treatment of severe von Willebrand disease: a cross-over randomized trial

1992 • 115 citations

Thrombosis following desmopressin for uremic bleeding

1988 • 114 citations

Molecular genetics of von Willebrand disease

1992 • 113 citations

Immunologic Studies of Antihemophilic Factor (AHF, Factor VIII). V. Immunologic Properties of AHF Subunits Produced by Salt Dissociation

1973 • 113 citations

Subunit composition of plasma von Willebrand factor in patients with the myeloproliferative syndrome

1986 • 112 citations

Antibody-induced von Willebrand's disease: a newly defined inhibitor syndrome

1976 • 109 citations

Isolation and characterization of a collagen binding domain in human von Willebrand factor.

1986 • 106 citations

Congenital bleeding disorders with long bleeding time and normal platelet count

1968 • 104 citations

Heterogeneous abnormalities in the multimeric structure, antigenic properties, and plasma-platelet content of factor VIII/von Willebrand factor in subtypes of classic (type I) and variant (type IIA) von Willebrand's disease.

1983 • 104 citations

Homozygous and heterozygous deletions of the von Willebrand factor gene in patients and carriers of severe von Willebrand disease.

1988 • 102 citations

von Willebrand Disease Masquerading as Haemophilia A

1992 • 102 citations

Thrombocytopenia associated with pregnancy in a patient with type IIB von Willebrand's disease

1987 • 101 citations

von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib.

1992 • 100 citations

Comparison of four virus-inactivated plasma concentrates for treatment of severe von Willebrand disease: a cross-over randomized trial

1992 • 99 citations

Selective inactivation of the Arg-Gly-Asp-Ser (RGDS) binding site in von Willebrand factor by site-directed mutagenesis.

1992 • 98 citations

Localization of a factor VIII binding domain on a 34 kilodalton fragment of the N-terminal portion of von Willebrand factor

1987 • 98 citations

Von Willebrand Factor: Clinical Features of Inherited and Acquired Disorders

1991 • 97 citations

Platelet von Willebrand factor: an important determinant of the bleeding time in type I von Willebrand's disease

1986 • 97 citations

Genetic heterogeneity of severe von Willebrand disease type III in the German population

1994 • 96 citations

Topology and order of formation of interchain disulfide bonds in von Willebrand factor

1987 • 95 citations

Substructure of human von Willebrand factor. Proteolysis by V8 and characterization of two functional domains.

1986 • 94 citations

Biological effect of desmopressin in eight patients with type 2n (‘Normandy’) von Willebrand disease

1994 • 94 citations

Atherosclerosis and von Willebrand factor

1984 • 93 citations

FACTOR VIII COAGULANT ACTIVITY AND FACTOR VIII-LIKE ANTIGEN: INDEPENDENT MOLECULAR ENTITIES

1973 • 93 citations

Characterization of the von Willebrand Factor Gene (VWF) in von Willebrand Disease Type III Patients from 24 Families of Swedish and Finnish Origin

1994 • 92 citations

The effect of von Willebrand factor on activation of factor VIII by factor Xa

1990 • 90 citations

A new von Willebrand variant (type I, New York): increased ristocetin- induced platelet aggregation and plasma von Willebrand factor containing the full range of multimers

1986 • 89 citations

Von Willebrand factor multimer patterns in von Willebrand's disease

1983 • 87 citations

Estrogen stimulates von Willebrand factor production by cultured endothelial cells

1984 • 86 citations

Expression of von Willebrand factor "Normandy": an autosomal mutation that mimics hemophilia A.

1991 • 86 citations

Molecular genetics of von Willebrand disease

1992 • 85 citations

von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure.

1993 • 83 citations

Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis.

1991 • 83 citations

Epitope mapping of the von Willebrand factor subunit distinguishes fragments present in normal and type IIA von Willebrand disease from those generated by plasmin.

1987 • 83 citations

Von Willebrand Disease

1985 • 83 citations

Defective dimerization of von Willebrand factor subunits due to a Cys-> Arg mutation in type IID von Willebrand disease.

1996 • 83 citations

Kinetics of factor VIII-von Willebrand factor association

1996 • 83 citations

Abnormal binding of factor VIII is linked with the substitution of glutamine for arginine 91 in von Willebrand factor in a variant form of von Willebrand disease.

1991 • 80 citations

A new variant of dominant type II von Willebrand's disease with aberrant multimeric pattern of factor VIII-related antigen (type IID)

1984 • 79 citations

In vitro correction of the abnormal multimeric structure of von Willebrand factor in type IIa von Willebrand's disease.

1985 • 79 citations

Inherited Diseases of Platelet Glycoproteins: Considerations for Rapid Molecular Characterization

1994 • 77 citations

Biosynthesis of the subunits of factor VIIIR by bovine aortic endothelial cells.

1983 • 77 citations

Replacement Therapy with Virus—Inactivated Plasma Concentrates in von Willebrand Disease

1992 • 76 citations

Consistency of responses to repeated DDAVP infusions in patients with von Willebrand's disease and hemophilia A

1989 • 74 citations

Commentary: a new classification for von Willebrand disease

1994 • 72 citations

A monoclonal antibody to von Willebrand factor (vWF) inhibits factor VIII binding. Localization of its antigenic determinant to a nonadecapeptide at the amino terminus of the mature vWF polypeptide.

1989 • 72 citations

Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor.

1991 • 72 citations

Severe type III von Willebrand's disease caused by deletion of exon 42 of the von Willebrand factor gene: family studies that identify carriers of the condition and a compound heterozygous individual

1990 • 71 citations

Platelet-type von Willebrand Disease

1996 • 69 citations

Mutations of von Willebrand factor gene in families with von Willebrand disease in the Aland Islands.

1993 • 68 citations

Von Willebrand's disease with spontaneous platelet aggregation induced by an abnormal plasma von Willebrand factor.

1985 • 67 citations

Characterization of von Willebrand factor gene defects in two unrelated patients with type IIC von Willebrand disease

1994 • 67 citations

Nonsense mutations of the von Willebrand factor gene in patients with von Willebrand disease type III and type I.

1992 • 66 citations

Molecular characterization of a unique von Willebrand disease variant. A novel mutation affecting von Willebrand factor/factor VIII interaction

1991 • 66 citations

The effects of epinephrine infusion in patients with von Willebrand's disease.

1976 • 65 citations

High-resolution analysis of von Willebrand factor multimeric composition defines a new variant of type I von Willebrand disease with aberrant structure but presence of all size multimers (type IC)

1985 • 64 citations

Identification of two mutations (Arg611Cys and Arg611His) in the A1 loop of von Willebrand factor (vWF) responsible for type 2 von Willebrand disease with decreased platelet-dependent function of vWF [see comments]

1995 • 63 citations

Evidence for a von Willebrand factor defect in factor VIII binding in three members of a family previously misdiagnosed mild haemophilia A and haemophilia A carriers: consequences for therapy and genetic counselling

1990 • 63 citations

Consistency of responses to repeated DDAVP infusions in patients with von Willebrand's disease and hemophilia A

1989 • 63 citations

Intranasal desmopressin (DDAVP) by spray in mild hemophilia A and von Willebrand's disease type I

1990 • 62 citations

von Willebrand Factor and Platelet Functiona

1991 • 60 citations

Identification of two point mutations in the von Willebrand factor gene of three families with the ‘Normandy’variant of von Willebrand disease

1991 • 60 citations

Expressed full-length von Willebrand factor containing missense mutations linked to type IIB von Willebrand disease shows enhanced binding to platelets

1992 • 60 citations

The heterogeneity of type IIA von Willebrand's disease: studies with protease inhibitors

1986 • 59 citations

Localization of a collagen-interactive domain of human von Willebrand factor between amino acid residues Gly 911 and Glu 1,365

1987 • 59 citations

Mutations in Severe, Type III von Willebrand’s Disease in the Dutch Population: Candidate Missense and Nonsense Mutations Associated with Reduced Levels of von Willebrand Factor Messenger RNA

1992 • 58 citations

von Willebrand's disease characterized by increased ristocetin sensitivity and the presence of all von Willebrand factor multimers in plasma

1986 • 57 citations

On laboratory problems in diagnosing mild von Willebrand's disease

1992 • 55 citations

von Willebrand's disease characterized by increased ristocetin sensitivity and the presence of all von Willebrand factor multimers in plasma

1986 • 55 citations

A new variant of dominant type II von Willebrand's disease with aberrant multimeric pattern of factor VIII-related antigen (type IID)

1984 • 55 citations

Acquired type II von Willebrand's disease: demonstration of a complexed inhibitor of the von Willebrand factor‐platelet interaction and response to treatment

1988 • 54 citations

Commentary: a new classification for von Willebrand disease

1994 • 54 citations

Possible effect of secretor locus on plasma concentration of factor VIII and von Willebrand factor

1989 • 54 citations

Identification of a candidate missense mutation in a family with von Willebrand disease type IIC

1995 • 54 citations

Leu 697-->Val mutation in mature von Willebrand factor is responsible for type IIB von Willebrand disease

1994 • 54 citations

Requirements of von Willebrand factor to protect factor VIII from inactivation by activated protein C

1996 • 54 citations

Type IIB von Willebrand's disease presenting as thrombocytopenia during pregnancy

1987 • 52 citations

Severe von Willebrand disease due to a defect at the level of von Willebrand factor mRNA expression: detection by exonic PCR-restriction fragment length polymorphism analysis.

1991 • 52 citations

A relatively high frequency of severe (type III) von Willebrand's disease in Israel

1986 • 51 citations

The Factor VIII Abnormality in Severe von Willebrand's Disease

1979 • 51 citations

Acquired von Willebrand Disease Due to Inhibitor of Human Myeloma Protein Specific for von Willebrand Factor

1987 • 51 citations

The defective interaction between von Willebrand factor and factor VIII in a patient with type 1 von Willebrand disease is caused by substitution of Arg19 and His54 in mature von Willebrand factor

1996 • 49 citations

Therapy of von Willebrand Disease

1993 • 48 citations

DDAVP in type IIa von Willebrand's disease

1986 • 47 citations

Von Willebrand factor multimer patterns in von Willebrand's disease

1983 • 47 citations

von Willebrand's disease

1992 • 47 citations

Subunit composition of oligomeric human von Willebrand factor.

1983 • 47 citations

Analysis of the relationship of von Willebrand disease (vWD) and hereditary hemorrhagic telangiectasia and identification of a potential type IIA vWD mutation (IIe865 to Thr).

1991 • 46 citations

Hyper‐responsiveness to DDAVP for patients with type I von Willebrand's disease and normal intra‐platelet von Willebrand factor

1988 • 45 citations

Acquired Von Willebrand's Disease

1992 • 44 citations

Effects of the mutant von Willebrand factor gene in von Willebrand disease

1995 • 44 citations

Laboratory Diagnosis of von Willebrand's Disease

1991 • 44 citations

Standard Nomenclature for Factor VIII and von Willebrand Factor: A Recommendation by the International Committee on Thrombosis and Haemostasis

1985 • 43 citations

Germ-line mosaicism for a valine-to-methionine substitution at residue 553 in the glycoprotein Ib-binding domain of von Willebrand factor, causing type IIB von Willebrand disease.

1992 • 43 citations

The mutation Arg (53)----Trp causes von Willebrand disease Normandy by abolishing binding to factor VIII. Studies with recombinant von Willebrand factor

1992 • 43 citations

von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene [published erratum appears in Blood 1995 Sep 15;86(6):2461]

1994 • 42 citations

A patient with von Willebrand's disease characterized by a compound heterozygosity for a substitution of Arg by Gln in the putative factor‐VIII‐binding domain of von Willebrand factor (vWF) on one allele and very low levels of mRNA from the second vWF allele

1992 • 42 citations

A new variant of type II von Willebrand disease with aberrant multimeric structure of plasma but not platelet von Willebrand factor (type IIF)

1986 • 42 citations

Pathogenesis of antibody‐induced acquired von willebrand syndrome

1980 • 42 citations

The role of platelet von Willebrand factor in platelet adhesion and thrombus formation: a study of 34 patients with various subtypes of type I von Willebrand disease

1994 • 41 citations

Identification of a new nonsense mutation in the von Willebrand factor gene in patients with von Willebrand disease type III

1992 • 40 citations

Duplication of a methionine within the glycoprotein Ib binding domain of von Willebrand factor detected by denaturing gradient gel electrophoresis in a patient with type IIB von Willebrand disease

1991 • 38 citations

1-Desamino-8-D-Arginine Vasopressin (DDAVP) Infusion in Type IIB von Willebrand’s Disease: Shortening of Bleeding Time and Induction of a Variable Pseudothrombocytopenia

1990 • 38 citations

Three different frameshift mutations of the tyrosinase gene in type IA oculocutaneous albinism.

1991 • 38 citations

ABNORMAL STRUCTURE OF VON WILLEBRAND FACTOR IN MYELOPROLIFERATIVE SYNDROME IS ASSOCIATED WITH EITHER THROMBOTIC OR BLEEDING DIATHESIS

1987 • 38 citations

A single cytosine deletion in exon 18 of the von Willebrand factor gene is the most common mutation in Swedish vWD type III patients

1992 • 38 citations

Hypothyroidism and acquired von Willebrand disease

1991 • 37 citations

Proteolytic cleavage of the precursor of von Willebrand factor is not essential for multimer formation.

1988 • 37 citations

Von Willebrand's Disease—Fifty Years Old

1977 • 36 citations

Characterization of recombinant von Willebrand factor corresponding to mutations in type IIA and type IIB von Willebrand disease

1992 • 36 citations

Treatment of von Willebrand's Disease

1991 • 35 citations

Variant von Willebrand's disease type B--revisited

1982 • 34 citations

Recombinant von Willebrand factor Arg578–>Gln. A type IIB von Willebrand disease mutation affects binding to glycoprotein Ib but not to collagen or heparin.

1992 • 34 citations

Sublocalization of von Willebrand factor pseudogene to 22q11.22?q11.23 by in situ hybridization in a 46,X,t(X;22)(pter;q11.21) translocation

1989 • 34 citations

Abnormal Structure of von Willebrand Factor in Myeloproliferative Syndrome Is Associated to Either Thrombotic or Bleeding Diathesis

1987 • 34 citations

Functional analysis of a type IIB von Willebrand disease missense mutation: increased binding of large von Willebrand factor multimers to platelets.

1992 • 34 citations

A de novo and heterozygous gene deletion causing a variant of von Willebrand disease

1990 • 33 citations

von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene [published erratum appears in Blood 1995 Sep 15;86(6):2461]

1994 • 32 citations

A variant of type II von willebrand disease with an abnormal triplet structure and discordant effects of protease inhibitors on plasma and platelet von willebrand factor structure

1987 • 32 citations

Von Willebrand's Disease

1975 • 32 citations

1-desamino-8-arginine-vasopressin corrects the hemostatic defects in type 2B von Willebrand's disease

1996 • 31 citations

Type IIB mutation His-505–>Asp implicates a new segment in the control of von Willebrand factor binding to platelet glycoprotein Ib.

1993 • 31 citations

Response to 1-Deamino-8-<i>D</i>-Arginine Vasopressin in von Willebrand Disease

1994 • 29 citations

Family studies in von Willebrand's disease by analysis of restriction fragment length polymorphisms and an intragenic variable number tandem repeat (VNTR) sequence

1990 • 29 citations

Von Willebrand disease investigated by two novel RFLPs

1988 • 28 citations

Characterization of Partial Gene Deletions in Type III von Willebrand Disease with Alloantibody Inhibitors

1994 • 28 citations

A perspective on the use of FVIII concentrates and cryoprecipitate prophylactically in surgery or therapeutically in severe bleeds in patients with von Willebrand disease unresponsive to DDAVP: results of an international survey. On behalf of the Subcommittee on von Willebrand Factor of the Scientific and Standardization Committee of the ISTH.

1995 • 28 citations

A common frameshift mutation in von Willebrand factor does not alter mRNA stability but interferes with normal propeptide processing

1996 • 28 citations

Evolution of human von Willebrand factor: CDNA sequence polymorphisms, repeated domains, and relationship to von Willebrand antigen II

1987 • 27 citations

IN MEMORY OF ERIK JORPES

1984 • 27 citations

A Perspective on the Use of FVIII Concentrates and Cryoprecipitate Prophylactically in Surgery or Therapeutically in Severe Bleeds in Patients with von Willebrand Disease Unresponsive to DDAVP: Results of an International Survey

1995 • 27 citations

Separation of human factor VIII activity from the von willebrand's antigen and ristocetin platelet aggregating activity

1974 • 25 citations

Carrier Detection in Severe (Type III) von Willebrand Disease Using Two Intragenic Restriction Fragment Length Polymorphisms

1988 • 25 citations

A stop codon in a patient with severe type III von Willebrand disease [letter]

1991 • 25 citations

Acquired von Willebrand's Disease in Malignancy

1992 • 24 citations

Type IIB von Willebrand's disease: gene mutations and clinical presentation in nine families from Denmark, Germany and Sweden

1992 • 23 citations

Recurring mutations at CpG dinucleotides in the region of the von Willebrand factor gene encoding the glycoprotein Ib binding domain, in patients with type IIB von Willebrand's disease

1991 • 22 citations

Abnormal proteolytic degradation of von willebrand factor after desmopressin infusion in a new subtype of von willebrand disease (ID)

1991 • 22 citations

In-frame deletion of von Willebrand factor A domains in a dominant type of von Willebrand disease

1993 • 22 citations

Non-Hodgkin's lymphoma of the lung diagnosed by gene rearrangement from bronchoalveolar lavage fluid: a fast and noninvasive method [letter]

1991 • 21 citations

Bleeding Time Tables

1990 • 19 citations

Three Distinct Candidate Point Mutations of the von Willebrand Factor Gene in Four Patients with Type IIA von Willebrand Disease

1992 • 18 citations

Identification of three candidate mutations causing type IIA von Willebrand disease using a rapid, nonradioactive, allele-specific hybridization method

1993 • 18 citations

Characterization of Three Mutations Causing von Willebrand Disease Type IIA in Five Unrelated Families

1992 • 18 citations

Effects of different amino‐acid substitutions in the leucine 694‐proline 708 segment of recombinant von Willebrand factor

1995 • 17 citations

Functional Analysis of the Arg91GIn Substitution in the Factor VIII Binding Domain of von Willebrand Factor Demonstrates Variable Phenotypic Expression

1993 • 16 citations

Clinical Use of Vasopressin Analogues

1989 • 16 citations

An Arg⁵⁴⁵→ Cys⁵⁴⁵ substitution mutation of the von Willebrand factor in type IIB von Willebrand's disease

1991 • 14 citations

Investigation of a large kindred with type IIB von Willebrand's disease, dominant inheritance and age‐dependent thrombocytopenia

1988 • 13 citations

Epitope mapping by cDNA expression of a monoclonal antibody which inhibits the binding of von Willebrand factor to platelet glycoprotein IIb/IIIa

1992 • 12 citations

Substitution of cysteine for phenylalanine 751 in mature von Willebrand factor is a novel candidate mutation in a family with type IIA von Willebrand disease

1993 • 12 citations

Autosomal recessive transmission of hemophilia A due to a von Willebrand factor mutation

1993 • 12 citations

Treatment of Von Willebrand's Disease

1992 • 11 citations

Two type of abnormal genes for plasminogen in families with a predisposition for thrombosis.

1991 • 10 citations

An infrequent DNA polymorphism associated with severe von Willebrand's disease

1990 • 9 citations

Rapid neonatal diagnosis of type IIB von Willebrand disease using the polymerase chain reaction [letter]

1991 • 9 citations

A rapid method for the diagnosis of von Willebrand's disease subtypes by the clinical laboratory.

1995 • 8 citations

Arg578Gln mutations in the von Willebrand factor gene in three unrelated cases of type IIB von Willebrand disease

1993 • 5 citations

Four agglutination assays evaluated for measurement of von Willebrand factor (ristocetin cofactor activity)

1995 • 4 citations

Von willebrand’s disease characterized by increased ristocetin sensitivity and the presence of all von willebrand factor multimers in plasma: A new subtype

1988 • 4 citations

Variant von Willebrand disease with defective binding to factor VIII: the first case from Japan.

1993 • 3 citations