Molecular basis of human von Willebrand disease: analysis of platelet von Willebrand factor mRNA.

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Epidemiological investigation of the prevalence of von Willebrand's disease

1987 • 956 citations

von Willebrand factor and von Willebrand disease [published erratum appears in Blood 1988 Mar;71(3):830]

1987 • 435 citations

Human von Willebrand Factor (vWF): Isolation of Complementary DNA (cDNA) Clones and Chromosomal Localization

1985 • 420 citations

Full-length von Willebrand factor (vWF) cDNA encodes a highly repetitive protein considerably larger than the mature vWF subunit.

1986 • 260 citations

Biosynthesis of major platelet proteins in human blood platelets

1987 • 225 citations

Structure of pre-pro-von Willebrand factor and its expression in heterologous cells

1986 • 212 citations

Enzymatic amplification of platelet-specific messenger RNA using the polymerase chain reaction.

1988 • 201 citations

The propeptide of von Willebrand Factor independently mediates the assembly of von Willebrand multimers

1988 • 192 citations

Gene deletions correlate with the development of alloantibodies in von Willebrand disease.

1987 • 170 citations

Structure-function relationship of human von Willebrand factor

1987 • 164 citations

Nucleotide sequence of pre-pro-von Willebrand factor cDNA

1986 • 152 citations

Homozygous and heterozygous deletions of the von Willebrand factor gene in patients and carriers of severe von Willebrand disease.

1988 • 102 citations

Epitope mapping of the von Willebrand factor subunit distinguishes fragments present in normal and type IIA von Willebrand disease from those generated by plasmin.

1987 • 83 citations

Cleavage of human von Willebrand factor by platelet calcium-activated protease

1985 • 80 citations

In vitro correction of the abnormal multimeric structure of von Willebrand factor in type IIa von Willebrand's disease.

1985 • 79 citations

The heterogeneity of type IIA von Willebrand's disease: studies with protease inhibitors

1986 • 59 citations

Molecular cloning of the human gene for von Willebrand factor and identification of the transcription initiation site.

1987 • 50 citations

Molecular genetic analysis of porcine von Willebrand disease: tight linkage to the von Willebrand factor locus

1988 • 31 citations

Genetic linkage of two intragenic restriction fragment length polymorphisms with von Willebrand's disease type IIA. Evidence for a defect in the von Willebrand factor gene.

1988 • 30 citations

Evolution of human von Willebrand factor: CDNA sequence polymorphisms, repeated domains, and relationship to von Willebrand antigen II

1987 • 27 citations

Expression of abnormal von Willebrand factor by endothelial cells from a patient with type IIA von Willebrand disease.

1987 • 25 citations

Cloning of cDNA and Genomic DNA for Human von Willebrand Factor

1986 • 22 citations

Frequency and distribution of rare electrophoretic mobility variants in a population of human newborns in Ann Arbor, Michigan

1987 • 19 citations