Proteolytic cleavage of the precursor of von Willebrand factor is not essential for multimer formation.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Synthesis of Antihemophilic Factor Antigen by Cultured Human Endothelial Cells

1973 • 1,303 citations

High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment

1984 • 898 citations

Human blood platelet adhesion to artery subendothelium is mediated by factor VIII–Von Willebrand factor bound to the subendothelium

1979 • 652 citations

Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation.

1986 • 609 citations

The complex multimeric composition of factor VIII/von Willebrand factor

1981 • 572 citations

Improved oligonudeotide site-directed rautagenesis using M13 vectors

1985 • 545 citations

Variant von Willebrand's Disease

1980 • 516 citations

The gapped duplex DNA approach to oligonucleotide-directed mutation construction

1984 • 511 citations

Stabilization of Factor VIII in Plasma by the von Willebrand Factor

1977 • 421 citations

Human von Willebrand Factor (vWF): Isolation of Complementary DNA (cDNA) Clones and Chromosomal Localization

1985 • 420 citations

Decreased adhesion of platelets to subendothelium in von Willebrand's disease.

1974 • 391 citations

Synthesis of Factor VIII Antigen by Cultured Guinea Pig Megakaryocytes

1977 • 390 citations

Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localization.

1984 • 313 citations

Cloning and characterization of two cDNAs coding for human von Willebrand factor.

1985 • 302 citations

Biosynthesis of von Willebrand protein by human megakaryocytes.

1985 • 271 citations

Full-length von Willebrand factor (vWF) cDNA encodes a highly repetitive protein considerably larger than the mature vWF subunit.

1986 • 260 citations

Factor VIII-related protein circulates in normal human plasma as high molecular weight multimers

1980 • 238 citations

Structure of pre-pro-von Willebrand factor and its expression in heterologous cells

1986 • 212 citations

cDNA sequences for human von Willebrand factor reveal five types of repeated domains and five possible protein sequence polymorphisms

1986 • 204 citations

Substructure of human von Willebrand factor.

1985 • 198 citations

The propeptide of von Willebrand Factor independently mediates the assembly of von Willebrand multimers

1988 • 192 citations

Response to infusions of polyelectrolyte fractionated human factor VIII concentrate in human haemophilia A and von Willebrand's disease

1982 • 180 citations

Molecular cloning of cDNA for human von willebrand factor: Authentication by a new method

1985 • 162 citations

Propolypeptide of von Willebrand Factor Circulates in Blood and Is Identical to von Willebrand Antigen II

1986 • 160 citations

Construction of cDNA coding for human von Willebrand factor using antibody probes for colony-screening and mapping of the chromosomal gene

1985 • 157 citations

The effect of calcium on the secretion of factor VIII-related antigen by cultured human endothelial cells

1983 • 151 citations

Expression of variant von Willebrand factor (vWF) cDNA in heterologous cells: requirement of the pro-polypeptide in vWF multimer formation.

1987 • 127 citations

Divergent fates of von Willebrand factor and its propolypeptide (von Willebrand antigen II) after secretion from endothelial cells.

1987 • 105 citations

Expression of preprosomatostatin in heterologous cells: Biosynthesis, posttranslational processing, and secretion of mature somatostatin

1984 • 96 citations

Heterogeneity of human factor VIII. II. Characterization of forms of factor VIII binding to platelets in the presence of ristocetin.

1978 • 81 citations

Studies on factor VIII-related protein

1979 • 69 citations

Comparison of secretion and subcellular localization of von Willebrand protein with that of thrombospondin and fibronectin in cultured human vascular endothelial cells

1985 • 67 citations

The haemostatic plug in haemophilia A: a morphological study of haemostatic plug formation in bleeding time skin wounds of patients with severe haemophilia A

1984 • 58 citations

Endothelial cell synthesis of von Willebrand antigen II, von Willebrand factor, and von Willebrand factor/von Willebrand antigen II complex.

1985 • 53 citations

Preferential binding of high molecular weight forms of von Willebrand factor to fibrillar collagen☆

1983 • 53 citations

Structural studies of the functional heterogeneity of von Willebrand protein polymers

1981 • 49 citations

Dispersity of human factor VIII - Von Willebrand factor

1978 • 33 citations

The proliferation of human umbilical vein endothelial cells in serum-free medium

1983 • 21 citations

An explanation for minor multimer species in endothelial cell-synthesized von Willebrand factor.

1986 • 15 citations