Induction of specific storage organelles by von Willebrand factor propolypeptide

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Synthesis of Antihemophilic Factor Antigen by Cultured Human Endothelial Cells

1973 • 1,303 citations

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

1978 • 1,284 citations

[32] Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors

1983 • 1,093 citations

NEW CYTOPLASMIC COMPONENTS IN ARTERIAL ENDOTHELIA

1964 • 1,062 citations

Pathways of Protein Secretion in Eukaryotes

1985 • 1,050 citations

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies.

1989 • 993 citations

PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes

1989 • 878 citations

Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells

1982 • 698 citations

Cell Biology of von Willebrand Factor

1990 • 604 citations

PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells

1989 • 538 citations

Variant von Willebrand's Disease

1980 • 516 citations

GMP-140 mediates adhesion of stimulated platelets to neutrophils

1990 • 515 citations

Inducible secretion of large, biologically potent von Willebrand factor multimers

1986 • 459 citations

Complement Proteins C5b-9 Induce Secretion of High Molecular Weight Multimers of Endothelial von Willebrand Factor and Translocation of Granule Membrane Protein GMP-140 to the Cell Surface

1989 • 442 citations

von Willebrand factor and von Willebrand disease [published erratum appears in Blood 1988 Mar;71(3):830]

1987 • 435 citations

Synthesis of Factor VIII Antigen by Cultured Guinea Pig Megakaryocytes

1977 • 390 citations

Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localization.

1984 • 313 citations

von Willebrand factor and von Willebrand disease [published erratum appears in Blood 1988 Mar;71(3):830]

1987 • 311 citations

Cloning and characterization of two cDNAs coding for human von Willebrand factor.

1985 • 302 citations

Identification of disulfide-bridged substructures within human von Willebrand factor

1987 • 262 citations

Changes in cytosolic Ca2+ associated with von Willebrand factor release in human endothelial cells exposed to histamine. Study of microcarrier cell monolayers using the fluorescent probe indo-1.

1987 • 225 citations

Clathrin-coated vesicular transport of secretory proteins during the formation of ACTH-containing secretory granules in AtT20 cells.

1986 • 220 citations

Secretion of tissue-type plasminogen activator and plasminogen activator inhibitor by cultured human endothelial cells: modulation by thrombin, endotoxin, and histamine.

1987 • 209 citations

The propeptide of von Willebrand Factor independently mediates the assembly of von Willebrand multimers

1988 • 192 citations

Thrombin-mediated release of factor VIII antigen from human umbilical vein endothelial cells in culture

1982 • 178 citations

Effect of von Willebrand factor coexpression on the synthesis and secretion of factor VIII in Chinese hamster ovary cells.

1989 • 178 citations

Composition of the von Willebrand factor storage organelle (Weibel-Palade body) isolated from cultured human umbilical vein endothelial cells.

1987 • 176 citations

Proteolytic processing in the biosynthesis of insulin and other proteins.

1974 • 172 citations

Studies on the Conversion of Proinsulin to Insulin

1973 • 168 citations

Biosynthesis of von Willebrand protein by human endothelial cells. Identification of a large precursor polypeptide chain.

1983 • 166 citations

Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor.

1986 • 164 citations

Fibrin induces release of von Willebrand factor from endothelial cells.

1987 • 163 citations

Propolypeptide of von Willebrand Factor Circulates in Blood and Is Identical to von Willebrand Antigen II

1986 • 160 citations

Molecular Sorting in the Secretory Pathway

1989 • 155 citations

The effect of calcium on the secretion of factor VIII-related antigen by cultured human endothelial cells

1983 • 151 citations

Eccentric localization of von Willebrand factor in an internal structure of platelet alpha-granule resembling that of Weibel-Palade bodies

1985 • 150 citations

[63] endo-β-N-Acetylglucosaminidase from Streptomyces plicatus

1978 • 149 citations

The propeptide of preprosomatostatin mediates intracellular transport and secretion of alpha-globin from mammalian cells.

1989 • 138 citations

Domains involved in multimer assembly of von willebrand factor (vWF): multimerization is independent of dimerization.

1990 • 134 citations

In cow anterior pituitary, growth hormone and prolactin can be packed in separate granules of the same cell.

1985 • 130 citations

Expression of variant von Willebrand factor (vWF) cDNA in heterologous cells: requirement of the pro-polypeptide in vWF multimer formation.

1987 • 127 citations

Sorting within the regulated secretory pathway occurs in the trans-Golgi network.

1990 • 127 citations

In vitro Multimerization of von Willebrand Factor Is Triggered by Low pH

1989 • 116 citations

Amino-terminal sequences of prosomatostatin direct intracellular targeting but not processing specificity

1989 • 108 citations

Divergent fates of von Willebrand factor and its propolypeptide (von Willebrand antigen II) after secretion from endothelial cells.

1987 • 105 citations

GOLGI ORIGIN OF TUBULAR INCLUSIONS IN ENDOTHELIAL CELLS

1970 • 98 citations

Topology and order of formation of interchain disulfide bonds in von Willebrand factor

1987 • 95 citations

Substructure of human von Willebrand factor. Proteolysis by V8 and characterization of two functional domains.

1986 • 94 citations

The functional domains of coagulation factor VIII:C.

1986 • 87 citations

Cell-specific processing of preprosomatostatin in cultured neuroendocrine cells.

1987 • 84 citations

Immunofluorescent localization of adhesive glycoproteins in resting and thrombin-stimulated platelets.

1984 • 82 citations

Comparison of secretion and subcellular localization of von Willebrand protein with that of thrombospondin and fibronectin in cultured human vascular endothelial cells

1985 • 67 citations

Efficient targeting to storage granules of human proinsulins with altered propeptide domain.

1988 • 64 citations

Factor-VIII/von Willebrand factor

2015 • 61 citations

Coagulation and Bleeding Disorders: The Role of Factor VIII and von Willebrand Factor

1989 • 55 citations

Endothelial cell synthesis of von Willebrand antigen II, von Willebrand factor, and von Willebrand factor/von Willebrand antigen II complex.

1985 • 53 citations

Storage and Secretion of von Willebrand Factor by Endothelial Cells

1988 • 52 citations

Ultrastructure of "tubular body" in the endothelial cells of the ocular blood vessels.

1970 • 49 citations

Immunohistological comparison of platelet factor 4 (PF4), fibronectin (Fn) and factor VIII related antigen (VIIIR:Ag) in human platelet granules

1982 • 47 citations

Intracellular localization of factor VIII-related antigen and fibronectin in cultured human endothelial cells: evidence for divergent routes of intracellular translocation.

1984 • 37 citations

Proteolytic cleavage of the precursor of von Willebrand factor is not essential for multimer formation.

1988 • 37 citations

Tubular Elements in Platelet Granules

1968 • 29 citations

Evolution of human von Willebrand factor: CDNA sequence polymorphisms, repeated domains, and relationship to von Willebrand antigen II

1987 • 27 citations

Variants of human tissue-type plasminogen activator substituted at the protease cleavage site and glycosylation sites, and truncated at the N- and C-termini

1989 • 21 citations

Factor VIII—von Willebrand Factor

2021 • 13 citations