Cell Biology of von Willebrand Factor

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Synthesis of Antihemophilic Factor Antigen by Cultured Human Endothelial Cells

1973 • 1,303 citations

Unusually Large Plasma Factor VIII: von Willebrand Factor Multimers in Chronic Relapsing Thrombotic Thrombocytopenic Purpura

1982 • 1,105 citations

The platelet membrane glycoprotein IIb-IIIa complex

1988 • 1,031 citations

GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies.

1989 • 993 citations

Epidemiological investigation of the prevalence of von Willebrand's disease

1987 • 956 citations

PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes

1989 • 878 citations

Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells

1982 • 698 citations

The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets.

1985 • 594 citations

The role of blood flow in platelet adhesion, fibrin deposition, and formation of mural thrombi

1973 • 587 citations

The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.

1986 • 575 citations

The complex multimeric composition of factor VIII/von Willebrand factor

1981 • 572 citations

Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.

1987 • 571 citations

Variant von Willebrand's Disease

1980 • 516 citations

Amino acid sequence of human von Willebrand factor

1986 • 486 citations

Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II.

1982 • 463 citations

Inducible secretion of large, biologically potent von Willebrand factor multimers

1986 • 459 citations

A monoclonal antibody to a membrane glycoprotein binds only to activated platelets.

1984 • 456 citations

Complement Proteins C5b-9 Induce Secretion of High Molecular Weight Multimers of Endothelial von Willebrand Factor and Translocation of Granule Membrane Protein GMP-140 to the Cell Surface

1989 • 442 citations

A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated platelets.

1984 • 426 citations

Stabilization of Factor VIII in Plasma by the von Willebrand Factor

1977 • 421 citations

Human von Willebrand Factor (vWF): Isolation of Complementary DNA (cDNA) Clones and Chromosomal Localization

1985 • 420 citations

The factor VIII complex: structure and function

1981 • 408 citations

Decreased adhesion of platelets to subendothelium in von Willebrand's disease.

1974 • 391 citations

Synthesis, processing, and secretion of recombinant human factor VIII expressed in mammalian cells.

1988 • 385 citations

The relationship of N-linked glycosylation and heavy chain-binding protein association with the secretion of glycoproteins.

1987 • 357 citations

Vesicles and cisternae in the trans golgi apparatus of human fibroblasts are acidic compartments

1985 • 350 citations

Cloning and characterization of two cDNAs coding for human von Willebrand factor.

1985 • 302 citations

Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectin

1985 • 299 citations

Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoproteins Ib and IIb-IIIa

1987 • 291 citations

A major factor VIII binding domain resides within the amino-terminal 272 amino acid residues of von Willebrand factor.

1987 • 263 citations

Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate.

1989 • 260 citations

Evidence that three adhesive proteins interact with a common recognition site on activated platelets.

1984 • 254 citations

Inactivation of human factor VIII by activated protein C. Cofactor activity of protein S and protective effect of von Willebrand factor.

1988 • 244 citations

The role of platelet membrane glycoproteins Ib and IIb-IIIa in platelet adherence to human artery subendothelium

1986 • 237 citations

Changes in cytosolic Ca2+ associated with von Willebrand factor release in human endothelial cells exposed to histamine. Study of microcarrier cell monolayers using the fluorescent probe indo-1.

1987 • 225 citations

Association of the factor VIII light chain with von Willebrand factor.

1988 • 223 citations

Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID, and IIE).

1986 • 217 citations

Von Willebrand factor in the vessel wall mediates platelet adherence

1985 • 204 citations

The propeptide of von Willebrand Factor independently mediates the assembly of von Willebrand multimers

1988 • 192 citations

Platelet glycoprotein IIb-IIIa-like proteins mediate endothelial cell attachment to adhesive proteins and the extracellular matrix.

1987 • 185 citations

Thrombin-mediated release of factor VIII antigen from human umbilical vein endothelial cells in culture

1982 • 178 citations

Composition of the von Willebrand factor storage organelle (Weibel-Palade body) isolated from cultured human umbilical vein endothelial cells.

1987 • 176 citations

Bernard-Soulier syndrome: a new platelet glycoprotein abnormality. Its relationship with platelet adhesion to subendothelium and with the factor VIII von Willebrand protein.

1976 • 174 citations

von Willebrand factor interaction with the glycoprotein IIb/IIa complex. Its role in platelet function as demonstrated in patients with congenital afibrinogenemia.

1986 • 174 citations

Gene deletions correlate with the development of alloantibodies in von Willebrand disease.

1987 • 170 citations

Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor.

1986 • 164 citations

Fibrin induces release of von Willebrand factor from endothelial cells.

1987 • 163 citations

Molecular cloning of cDNA for human von willebrand factor: Authentication by a new method

1985 • 162 citations

Propolypeptide of von Willebrand Factor Circulates in Blood and Is Identical to von Willebrand Antigen II

1986 • 160 citations

Construction of cDNA coding for human von Willebrand factor using antibody probes for colony-screening and mapping of the chromosomal gene

1985 • 157 citations

A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728.

1987 • 156 citations

Factor VIII/von Willebrand factor in subendothelium mediates platelet adhesion

1985 • 152 citations

The effect of calcium on the secretion of factor VIII-related antigen by cultured human endothelial cells

1983 • 151 citations

Multimeric structure of factor VIII/von Willebrand factor in von Willebrand's disease.

1980 • 134 citations

Transplantation of normal bone marrow into a pig with severe von Willebrand's disease.

1986 • 133 citations

Localization of factor-VIII-related antigen in human vascular subendothelium

1980 • 130 citations

Characterization of 25 monoclonal antibodies to factor VIII-von Willebrand factor: relationship between ristocetin-induced platelet aggregation and platelet adherence to subendothelium

1984 • 129 citations

Expression of variant von Willebrand factor (vWF) cDNA in heterologous cells: requirement of the pro-polypeptide in vWF multimer formation.

1987 • 127 citations

Properties of human asialo-factor VIII. A ristocetin-independent platelet-aggregating agent.

1981 • 126 citations

Human von Willebrand factor: a multivalent protein composed of identical subunits

1986 • 120 citations

In vitro Multimerization of von Willebrand Factor Is Triggered by Low pH

1989 • 116 citations

Factor VIII-related antigen in human blood platelets: localization and release by thrombin and collagen.

1979 • 106 citations

Divergent fates of von Willebrand factor and its propolypeptide (von Willebrand antigen II) after secretion from endothelial cells.

1987 • 105 citations

Native conformation of human von Willebrand protein. Analysis by electron microscopy and quasi-elastic light scattering.

1985 • 102 citations

Homozygous and heterozygous deletions of the von Willebrand factor gene in patients and carriers of severe von Willebrand disease.

1988 • 102 citations

GOLGI ORIGIN OF TUBULAR INCLUSIONS IN ENDOTHELIAL CELLS

1970 • 98 citations

Platelet von Willebrand factor: an important determinant of the bleeding time in type I von Willebrand's disease

1986 • 97 citations

Factor VIII Recombination After Dissociation by CaCl ₂

1973 • 96 citations

von Willebrand protein facilitates platelet incorporation in polymerizing fibrin.

1986 • 84 citations

Biosynthesis of the subunits of factor VIIIR by bovine aortic endothelial cells.

1983 • 77 citations

The Effects of Ristocetin and von Willebrand Factor on Platelet Electrophoretic Mobility

1978 • 75 citations

A monoclonal antibody to von Willebrand factor (vWF) inhibits factor VIII binding. Localization of its antigenic determinant to a nonadecapeptide at the amino terminus of the mature vWF polypeptide.

1989 • 72 citations

Factor VIII gene and hemophilia A.

1989 • 72 citations

The effect of thrombin on the complex between factor VIII and von Willebrand factor

1987 • 63 citations

Decreased platelet adhesion on vessel segments in von Willebrand's disease: a defect in initial platelet attachment.

1983 • 63 citations

Von Willebrand factor shares a distinctive cysteine-rich domain with thrombospondin and procollagen

1987 • 57 citations

Perturbation of human endothelial cells by thrombin or PMA changes the reactivity of their extracellular matrix towards platelets.

1987 • 56 citations

Early endothelial changes in experimental primate atherosclerosis.

1979 • 54 citations

Electron microscopic localization of factor-VIII-related antigen in adult human blood vessels

1982 • 54 citations

Endothelial cell synthesis of von Willebrand antigen II, von Willebrand factor, and von Willebrand factor/von Willebrand antigen II complex.

1985 • 53 citations

Storage and Secretion of von Willebrand Factor by Endothelial Cells

1988 • 52 citations

Subendothelial deposition of von Willebrand's factor requires the presence of endothelial cells.

1982 • 51 citations

Molecular cloning of the human gene for von Willebrand factor and identification of the transcription initiation site.

1987 • 50 citations

Immunohistological comparison of platelet factor 4 (PF4), fibronectin (Fn) and factor VIII related antigen (VIIIR:Ag) in human platelet granules

1982 • 47 citations

von Willebrand factor biosynthesis and partitioning between constitutive and regulated pathways of secretion after thrombin stimulation

1989 • 45 citations

The emergence of the endothelial cell lineage in the chick embryo can be detected by uptake of acetylated low density lipoprotein and the presence of a von Willebrand-like factor

1989 • 45 citations

Mediation of fibrin-induced release of von Willebrand factor from cultured endothelial cells by the fibrin beta chain.

1989 • 43 citations

Transcytosis and Traffic of Membranes in the Endothelial Cell

1981 • 40 citations

Polar secretion of von Willebrand factor by endothelial cells

1989 • 36 citations

Inhibition of Platelet-Collagen Interaction by Propolypeptide of von Willebrand Factor

1989 • 36 citations

Von Willebrand Factor in Cultured Human Vascular Endothelial Cells from Adult and Umbilical Cord Arteries and Veins

1986 • 35 citations

HYPOTHYROIDISM AND VON WILLEBRAND'S DISEASE

1987 • 35 citations

Structure of the Dictyostelium discoideum prestalk D11 gene and protein.

1985 • 29 citations

Platelet‐Aggregating Activity in Neuraminidase‐Treated Human Cryoprecipitates: Its Correlation with Factor‐VIII‐Related Antigen

1974 • 26 citations

Secretion of Weibel-Palade bodies observed in extra-alveolar vessels of rabbit lung

1983 • 25 citations

Expression of abnormal von Willebrand factor by endothelial cells from a patient with type IIA von Willebrand disease.

1987 • 25 citations

Adhesion of human platelets to purified solid-phase von willebrand factor: Studies of normal and bernard-soulier platelets

1983 • 23 citations

6 Von Willebrand factor and platelet function

1989 • 19 citations

Effects of ticlopidine and dexamethasone on fibronectin and factor VIII-related antigen synthesis by cultured endothelial cells

1983 • 15 citations

Electron Microscopy of von Willebrand Factor

1991 • 10 citations

Temperature-sensitive steps in the secretory pathway for von Willebrand factor in endothelial cells.

1989 • 6 citations