The molecular defect in type IIB von Willebrand disease. Identification of four potential missense mutations within the putative GpIb binding domain.

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

1988 • 1,582 citations

Epidemiological investigation of the prevalence of von Willebrand's disease

1987 • 956 citations

Restriction sites containing CpG show a higher frequency of polymorphism in human DNA

1984 • 586 citations

Structure of the gene for human von Willebrand factor

1989 • 497 citations

von Willebrand factor and von Willebrand disease [published erratum appears in Blood 1988 Mar;71(3):830]

1987 • 435 citations

Human von Willebrand Factor (vWF): Isolation of Complementary DNA (cDNA) Clones and Chromosomal Localization

1985 • 420 citations

Heightened Interaction between Platelets and Factor VIII/von Willebrand Factor in a New Subtype of von Willebrand's Disease

1980 • 381 citations

Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor.

1990 • 347 citations

von Willebrand factor. A reduced and alkylated 52/48-kDa fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein Ib.

1986 • 270 citations

Identification of disulfide-bridged substructures within human von Willebrand factor

1987 • 262 citations

Platelet Aggregation Induced by I-Desamino-8-D-Arginine Vasopressin (dDAVP) in Type IIb von Willebrand's Disease

1983 • 260 citations

Structure of pre-pro-von Willebrand factor and its expression in heterologous cells

1986 • 212 citations

Structure of the von Willebrand factor domain interacting with glycoprotein Ib.

1988 • 208 citations

cDNA sequences for human von Willebrand factor reveal five types of repeated domains and five possible protein sequence polymorphisms

1986 • 204 citations

Rapid, nonradioactive detection of mutations in the human genome by allele-specific amplification.

1989 • 176 citations

Gene deletions correlate with the development of alloantibodies in von Willebrand disease.

1987 • 170 citations

A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728.

1987 • 156 citations

Nucleotide sequence of pre-pro-von Willebrand factor cDNA

1986 • 152 citations

Direct sequencing of the gene for Maryland/German familial amyloidotic polyneuropathy type II and genotyping by allele-specific enzymatic amplification

1989 • 148 citations

Isolation of the von Willebrand Factor Domain Interacting with Platelet Glycoprotein Ib, Heparin, and Collagen and Characterization of Its Three Distinct Functional Sites

1989 • 147 citations

Localization of binding sites within human von Willebrand factor for monomeric type III collagen

1986 • 145 citations

Molecular basis of human von Willebrand disease: analysis of platelet von Willebrand factor mRNA.

1989 • 135 citations

Interaction of purified type IIB von Willebrand factor with the platelet membrane glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and initiates aggregation.

1985 • 106 citations

Isolation and characterization of a collagen binding domain in human von Willebrand factor.

1986 • 106 citations

Homozygous and heterozygous deletions of the von Willebrand factor gene in patients and carriers of severe von Willebrand disease.

1988 • 102 citations

Thrombocytopenia associated with pregnancy in a patient with type IIB von Willebrand's disease

1987 • 101 citations

The addition of endothelial cell growth factor and heparin to human umbilical vein endothelial cell cultures decreases plasminogen activator inhibitor-1 expression.

1988 • 87 citations

Severe type III von Willebrand's disease caused by deletion of exon 42 of the von Willebrand factor gene: family studies that identify carriers of the condition and a compound heterozygous individual

1990 • 71 citations

Von Willebrand's disease with spontaneous platelet aggregation induced by an abnormal plasma von Willebrand factor.

1985 • 67 citations

Type IIB von Willebrand's disease: differential clearance of endogenous versus transfused large multimer von willebrand factor

1982 • 62 citations

Molecular and cellular biology of von Willebrand factor.

1989 • 57 citations

Epidemiological investigation of the prevalence of von Willebrand's disease

1987 • 53 citations

USE OF POLYMERASE CHAIN REACTION-DETECTED SEQUENCE POLYMORPHISMS TO DOCUMENT ENGRAFTMENT FOLLOWING ALLOGENEIC BONE MARROW TRANSPLANTATION

1990 • 53 citations

Type IIB von Willebrand's disease presenting as thrombocytopenia during pregnancy

1987 • 52 citations

von Willebrand factor and von Willebrand disease.

2016 • 49 citations

von Willebrand factor synthesized by endothelial cells from a patient with type IIB von Willebrand disease supports platelet adhesion normally but has an increased affinity for platelets.

1989 • 44 citations

Postoperative thrombocytopenia in type IIB von Willebrand disease

1990 • 22 citations

Investigation of a large kindred with type IIB von Willebrand's disease, dominant inheritance and age‐dependent thrombocytopenia

1988 • 13 citations

Molecular characterization of anti-idiotype antibody-resistant variants of a murine B cell lymphoma.

1990 • 13 citations

Spontaneous platelet aggregation in type IIB tampa von willebrand disease is inhibited by the 52/48‐kDa fragment of normal von willebrand factor, which contains the GPIb binding domain

1989 • 5 citations

Thrombocytopenia associated with pregnancy in a patient with type IIB von Willebrand's disease

1987 • 5 citations

Severe type III von Willebrand's disease caused by deletion of exon 42 of the von Willebrand factor gene: family studies that identify carriers of the condition and a compound heterozygous individual

1990 • 1 citations