von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure.

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies

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Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1988 • 4,259 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

High-Efficiency Transformation of Mammalian Cells by Plasmid DNA

1987 • 729 citations

The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress.

1991 • 619 citations

The complex multimeric composition of factor VIII/von Willebrand factor

1981 • 572 citations

Variant von Willebrand's Disease

1980 • 516 citations

Structure of the gene for human von Willebrand factor

1989 • 497 citations

Gene conversion: Some implications for immunoglobulin genes

1981 • 496 citations

Platelets have more than one binding site for von Willebrand factor.

1983 • 459 citations

Heightened Interaction between Platelets and Factor VIII/von Willebrand Factor in a New Subtype of von Willebrand's Disease

1980 • 381 citations

Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear rate--dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier syndrome.

1978 • 368 citations

Structure and Function of von Willebrand Factor

1999 • 331 citations

von Willebrand factor. A reduced and alkylated 52/48-kDa fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein Ib.

1986 • 270 citations

RECOMBINATION BETWEEN REPEATED GENES IN MICROORGANISMS

1988 • 261 citations

Platelet Aggregation Induced by I-Desamino-8-D-Arginine Vasopressin (dDAVP) in Type IIb von Willebrand's Disease

1983 • 260 citations

Human von Willebrand factor gene and pseudogene: structural analysis and differentiation by polymerase chain reaction

1991 • 235 citations

Rapid and Efficient Site-Specific Mutagenesis without Phenotypic Selection

1989 • 233 citations

Pseudo-von Willebrand's Disease

1982 • 219 citations

Structure of the von Willebrand factor domain interacting with glycoprotein Ib.

1988 • 208 citations

Enzymatic amplification of platelet-specific messenger RNA using the polymerase chain reaction.

1988 • 201 citations

Platelet-type von Willebrand's disease: characterization of a new bleeding disorder

1982 • 197 citations

Detection of carriers of classic hemophilia using an immunologic assay for antihemophilic factor (factor VIII)

1971 • 189 citations

Evidence for frequent gene conversion in the steroid 21-hydroxylase P-450(C21) gene: implications for steroid 21-hydroxylase deficiency.

1988 • 173 citations

Metabolism and Function of Human Platelets Washed by Albumin Density Gradient Separation

1977 • 169 citations

Family studies and prenatal diagnosis in severe von Willebrand disease by polymerase chain reaction amplification of a variable number tandem repeat region of the von Willebrand factor gene

1990 • 160 citations

Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease.

1991 • 155 citations

Isolation of the von Willebrand Factor Domain Interacting with Platelet Glycoprotein Ib, Heparin, and Collagen and Characterization of Its Three Distinct Functional Sites

1989 • 147 citations

Dimeric ristocetin flocculates proteins, binds to platelets, and mediates von Willebrand factor-dependent agglutination of platelets

1991 • 137 citations

Identification of discontinuous von Willebrand factor sequences involved in complex formation with botrocetin. A model for the regulation of von Willebrand factor binding to platelet glycoprotein Ib.

1991 • 135 citations

Molecular basis of human von Willebrand disease: analysis of platelet von Willebrand factor mRNA.

1989 • 135 citations

The Structure and Function of von Willebrand Factor

1992 • 122 citations

The molecular defect in type IIB von Willebrand disease. Identification of four potential missense mutations within the putative GpIb binding domain.

1991 • 120 citations

Molecular basis of von Willebrand disease type IIB. Candidate mutations cluster in one disulfide loop between proposed platelet glycoprotein Ib binding sequences.

1991 • 117 citations

Spectrum of von Willebrand's Disease: a Study of 100 Cases

1977 • 110 citations

Identification of aspartic acid 514 through glutamic acid 542 as a glycoprotein Ib-IX complex receptor recognition sequence in von Willebrand factor. Mechanism of modulation of von Willebrand factor by ristocetin and botrocetin

1992 • 107 citations

Interaction of purified type IIB von Willebrand factor with the platelet membrane glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and initiates aggregation.

1985 • 106 citations

von Willebrand factor binds to platelets and induces aggregation in platelet-type but not type IIB von Willebrand disease.

1983 • 103 citations

A new von Willebrand variant (type I, New York): increased ristocetin- induced platelet aggregation and plasma von Willebrand factor containing the full range of multimers

1986 • 89 citations

Type IIB Tampa: a variant of von Willebrand disease with chronic thrombocytopenia, circulating platelet aggregates, and spontaneous platelet aggregation

1985 • 84 citations

Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor.

1991 • 72 citations

Von Willebrand's disease with spontaneous platelet aggregation induced by an abnormal plasma von Willebrand factor.

1985 • 67 citations

Studies on anti-von Willebrand factor (vWF) monoclonal antibody NMC-4, which inhibits both ristocetin- and botrocetin-induced vWF binding to platelet glycoprotein Ib

1991 • 67 citations

von Willebrand's disease characterized by increased ristocetin sensitivity and the presence of all von Willebrand factor multimers in plasma

1986 • 57 citations

Gene conversion in steroid 21-hydroxylase genes.

1990 • 56 citations

von Willebrand's disease characterized by increased ristocetin sensitivity and the presence of all von Willebrand factor multimers in plasma

1986 • 55 citations

von Willebrand's disease

1992 • 47 citations

Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin. Role of platelet activation, fibrinogen, and two distinct membrane receptors.

1987 • 46 citations

Distinct abnormalities in the interaction of purified types IIA and IIB von Willebrand factor with the two platelet binding sites, glycoprotein complexes Ib-IX and IIb-IIIa.

1990 • 44 citations

The complex multimeric composition of factor VIII/von Willebrand factor

1981 • 40 citations

Duplication of a methionine within the glycoprotein Ib binding domain of von Willebrand factor detected by denaturing gradient gel electrophoresis in a patient with type IIB von Willebrand disease

1991 • 38 citations

Independent assembly and secretion of a dimeric adhesive domain of von Willebrand factor containing the glycoprotein Ib-binding site

1991 • 31 citations

Comparison of the primary structure of the functional domains of human and porcine von Willebrand factor that mediate platelet adhesion

1992 • 28 citations

Enzymatic amplification of platelet-specific messenger RNA using the polymerase chain reaction.

1988 • 23 citations

A polymorphic Xba I site within the human von Willebrand factor (vWF) gene identified by a vWF cDNA clone

1986 • 23 citations

Platelet-type von Willebrand's disease: characterization of a new bleeding disorder

1982 • 19 citations

An HphI‐polymorphism in exon 28 of the von Willebrand factor gene, and its frequency among patients with various forms of von Willebrand's disease

1991 • 16 citations

Two TaqI RFLPs in the human von Willebrand factor gene

1987 • 15 citations

Recombination Between Repeated Genes In Microorganisms

1988 • 14 citations

A new von Willebrand variant (type I, New York): increased ristocetin- induced platelet aggregation and plasma von Willebrand factor containing the full range of multimers

1986 • 12 citations

Von Willebrand’s disease

1993 • 5 citations