Retinoids: present role and future potential

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Prevention of Second Primary Tumors with Isotretinoin in Squamous-Cell Carcinoma of the Head and Neck

1990 • 1,375 citations

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1991 • 1,298 citations

All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments]

1990 • 1,224 citations

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

1992 • 1,200 citations

All-trans-Retinoic Acid in Acute Promyelocytic Leukemia

1997 • 1,090 citations

The Role of the Vitamin D Endocrine System in Health and Disease

1989 • 1,041 citations

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

1992 • 966 citations

Nuclear receptor coactivators and corepressors.

1996 • 917 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia

1986 • 825 citations

Zinc fingers: Gilt by association

1988 • 799 citations

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

1993 • 738 citations

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

1991 • 672 citations

Evolution of the nuclear receptor gene superfamily.

1992 • 662 citations

Polarity-specific activities of retinoic acid receptors determined by a co-repressor

1995 • 569 citations

Retinoic Acid Receptors and Cellular Retinoid Binding Proteins: Complex Interplay in Retinoid Signaling*

1994 • 514 citations

Retinoids in cancer chemoprevention

1996 • 432 citations

All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs

1992 • 417 citations

A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients

1991 • 412 citations

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

1994 • 410 citations

Comparison of Low-Dose Isotretinoin with Beta Carotene to Prevent Oral Carcinogenesis

1993 • 402 citations

HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis

1990 • 390 citations

Prevention of skin cancer and reduction of keratotic skin lesions during acitretin therapy in renal transplant recipients: a double-blind, placebo-controlled study.

1995 • 385 citations

Adjuvant treatment of stage I lung cancer with high-dose vitamin A.

1993 • 353 citations

Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

1992 • 341 citations

Transcriptional Activation of the Human p21 Gene by Retinoic Acid Receptor

1996 • 314 citations

Anatomy of the Steroid Receptor Zinc Finger Region

1992 • 299 citations

All-trans Retinoic Acid for Acute Promyelocytic Leukemia: Results of the New York Study

1994 • 288 citations

Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways.

1995 • 282 citations

Enhancement of Regression of Cervical Intraepithelial Neoplasia II (Moderate Dysplasia) With Topically Applied All- trans -Retinoic Acid: a Randomized Trial

1994 • 273 citations

All-trans retinoic acid for the treatment of newly diagnosed acute promyelocytic leukemia. Japan Adult Leukemia Study Group [see comments]

1995 • 258 citations

Insulin-like growth factor binding protein 3 mediates retinoic acid- and transforming growth factor beta2-induced growth inhibition in human breast cancer cells.

1996 • 257 citations

Activation of Retinoid X Receptors Induces Apoptosis in HL-60 Cell Lines

1995 • 247 citations

A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter.

1991 • 240 citations

All-transretinoic acid followed by intensive chemotherapy gives a high complete remission rate and may prolong remissions in newly diagnosed acute promyelocytic leukemia: a pilot study on 26 cases

1992 • 240 citations

The human prostatic carcinoma cell line LNCaP expresses biologically active, specific receptors for 1 alpha,25-dihydroxyvitamin D3.

1992 • 226 citations

EB1089: A new vitamin D analogue that inhibits the growth of breast cancer cells in vivo and in vitro

1992 • 224 citations

Randomized placebo-controlled trial of isotretinoin in chemoprevention of bronchial squamous metaplasia.

1994 • 220 citations

Prevention of Second Primary Tumors With Isotretinoin in Patients With Squamous Cell Carcinoma of the Head and Neck: Long-term Follow-up

1994 • 208 citations

Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors.

1993 • 207 citations

Chemoprevention of mammary carcinoma by LGD1069 (Targretin): an RXR-selective ligand.

1996 • 202 citations

Two distinct actions of retinoid-receptor ligands

1996 • 200 citations

Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agent and in combination with tamoxifen.

1994 • 198 citations

p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells.

1995 • 197 citations

Initial clinical trial of a selective retinoid X receptor ligand, LGD1069.

1997 • 189 citations

The novel primary response gene MyD118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells.

1994 • 182 citations

Nuclear Receptors in Sicily: All in the Famiglia

1997 • 152 citations

Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells

1996 • 142 citations

The cellular retinoic acid binding protein I is dispensable.

1994 • 135 citations

N-(4-hydroxyphenyl)retinamide (4-HPR)-mediated biological actions involve retinoid receptor-independent pathways in human breast carcinoma

1995 • 129 citations

Commentary on and reprint of Huang M-E, Ye Y-C, Chen S-R, Chai J-R, Lu J-X, Zhoa L, Gu L-J, Wang Z-Y, Use of all-trans-retinoic acid in the treatment of acute promyelocytic leukemia, in Blood (1988) 72:567–572

2000 • 128 citations

Growth inhibition of HT-29 human colon cancer cells by analogues of 1,25-dihydroxyvitamin D3.

1994 • 127 citations

Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2.

1996 • 127 citations

Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells

1996 • 127 citations

Retinoic acid resistance of estradiol-independent breast cancer cells coincides with diminished retinoic acid receptor function

1993 • 126 citations

Induction of apoptosis by fenretinide (4HPR) in human ovarian carcinoma cells and its association with retinoic acid receptor expression

1996 • 121 citations

Stat1 Is Induced and Activated by All-Trans Retinoic Acid in Acute Promyelocytic Leukemia Cells

1997 • 120 citations

Phenotype‐specific “tissue” transglutaminase regulation in human neuroblastoma cells in response to retinoic acid: Correlation with cell death by apoptosis

1992 • 119 citations

Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells.

1996 • 118 citations

Differential induction of apoptosis by all-trans-retinoic acid and N-(4-hydroxyphenyl)retinamide in human head and neck squamous cell carcinoma cell lines.

1996 • 118 citations

Prevention of second primary tumours with etretinate in squamous cell carcinoma of the oral cavity and oropharynx. Results of a multicentric double-blind randomised study

1994 • 117 citations

Prospects of chemoprevention of human cancers with the synthetic retinoid fenretinide.

1994 • 117 citations

Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.

1991 • 114 citations

The Molecular and Genetic Dissection of the Retinoid Signaling Pathway

1995 • 113 citations

Modulation of Interferon (IFN)-inducible Gene Expression by Retinoic Acid

1996 • 110 citations

Retinoid-resistant estrogen receptor-negative human breast carcinoma cells transfected with retinoic acid receptor-alpha acquire sensitivity to growth inhibition by retinoids.

1994 • 109 citations

Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo.

1996 • 106 citations

Growth Inhibition and Induction of Apoptosis by Fenretinide in Small-Cell Lung Cancer Cell Lines

1995 • 103 citations

9-Cis retinoic acid inhibits growth of breast cancer cells and down-regulates estrogen receptor RNA and protein.

1994 • 102 citations

Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation.

1995 • 94 citations

Growth-inhibitory effects of vitamin D analogues and retinoids on human pancreatic cancer cells

1996 • 93 citations

BENEFICIAL EFFECT OF LOW-DOSE SYSTEMIC RETINOID IN COMBINATION WITH TOPICAL TRETINOIN FOR THE TREATMENT AND PROPHYLAXIS OF PREMALIGNANT AND MALIGNANT SKIN LESIONS IN RENAL TRANSPLANT RECIPIENTS

1995 • 91 citations

Mechanistic interrelationships between two superfamilies: the steroid/retinoid receptors and transforming growth factor-beta.

1992 • 90 citations

Suppression of squamous cell carcinoma growth and differentiation by retinoids.

1994 • 88 citations

WAF1/CIP1 increases the susceptibility of p53 non-functional malignant glioma cells to cisplatin-induced apoptosis.

1996 • 88 citations

Multi-institutional study of all-trans-retinoic acid as a differentiation therapy of refractory acute promyelocytic leukemia. Leukaemia Study Group of the Ministry of Health and Welfare.

1993 • 88 citations

Synergistic Antiproliferative Effect of Human Recombinant Interferons and Retinoic Acid in Cultured Breast Cancer Cells

1986 • 85 citations

Interaction of Retinoids and Tamoxifen on the Inhibition of Human Mammary Carcinoma Cell Proliferation

1987 • 84 citations

Estradiol induction of retinoic acid receptors in human breast cancer cells.

1993 • 81 citations

The efficacy of 9-cis retinoic acid in experimental models of cancer

1996 • 80 citations

Adjuvant Treatment with a Vitamin A Analogue (Etretinate) after Transurethral Resection of Superficial Bladder Tumors

1995 • 78 citations

Retinoids in prevention of skin cancer

1997 • 71 citations

Fenretinide (4-HPR) in chemoprevention of oral leukoplakia

1993 • 71 citations

Ligand-dependent occupancy of the retinoic acid receptor beta 2 promoter in vivo.

1994 • 65 citations

Apoptosis during Retinoic Acid-Induced Differentiation of F9 Embryonal Carcinoma Cells

1994 • 62 citations

Retinoids in Cancer Chemoprevention

1995 • 57 citations

Response and resistance to retinoic acid are mediated through the retinoic acid nuclear receptor gamma in human teratocarcinomas.

1994 • 54 citations

Modulation of growth and proliferation in squamous cell carcinoma by retinoic acid: A rationale for combination therapy with chemotherapeutic agents

1995 • 53 citations

1 alpha, 25-dihydroxyvitamin D3 and all-trans-retinoic acid inhibit the growth of a lung cancer cell line.

1996 • 53 citations

Loss of retinoic acid receptors in mouse skin and skin tumors is associated with activation of the ras(Ha) oncogene and high risk for premalignant progression.

1996 • 51 citations

Effects of retinoic acid and gamma-interferon on expression of retinoic acid receptor and cellular retinoic acid-binding protein in breast cancer cells.

1995 • 50 citations

Normal development, growth and reproduction in cellular retinoic acid binding protein-I (CRABPI) null mutant mice

1995 • 50 citations

Effects of topical tretinoin on dysplastic nevi.

1994 • 49 citations

Highlights of the Cancer Chemoprevention Studies in China

1993 • 49 citations

Cancer combination chemotherapy with retinoids: experimental rationale.

1994 • 48 citations

Potential role for retinoic acid receptor-gamma in the inhibition of breast cancer cells by selective retinoids and interferons.

1996 • 48 citations

Enhanced antitumor efficacy of cisplatin in combination with ALRT1057 (9-cis retinoic acid) in human oral squamous carcinoma xenografts in nude mice.

1996 • 48 citations

Retinoic acid inhibition of human breast carcinoma proliferation is accompanied by inhibition of the synthesis of a Mr 39,000 protein.

1990 • 45 citations

Vitamin A in Epithelial Differentiation and Skin Carcinogenesis

2009 • 41 citations

The Effect of Topical Tretinoin on Dysplastic Nevi

1990 • 40 citations

A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice.

1997 • 39 citations

Modulation of normal mammary epithelial cell proliferation, morphogenesis, and functional differentiation by retinoids: a comparison of the retinobenzoic acid derivative RE80 with retinoic acid.

1995 • 35 citations

Retinoic Acid Down-regulation of Fibronectin and Retinoic Acid Receptor α Proteins in NIH-3T3 Cells

1996 • 35 citations

13-cis-retinoic acid in chemoprevention of superficial bladder cancer. The National Bladder Cancer Group.

1992 • 34 citations

The Novel Primary Response Gene MyD118 and the Proto-Oncogenes myb, myc, and bcl-2 Modulate Transforming Growth Factor β1-induced Apoptosis of Myeloid Leukemia Cells

1994 • 33 citations

Retinoic acid receptors in retinoid responsive ovarian cancer cell lines detected by polymerase chain reaction following reverse transcription

1993 • 33 citations

Combination 13-cis-retinoic acid and interferon alpha-2a in the therapy of solid tumors.

1994 • 31 citations

Multifactorial mechanism for the potentiation of cisplatin (CDDP) cytotoxicity by all-trans retinoic acid (ATRA) in human ovarian carcinoma cell lines

1997 • 31 citations

Regulation of the human retinoic acid receptor alpha gene in the estrogen receptor negative human breast carcinoma cell lines SKBR-3 and MDA-MB-435.

1996 • 27 citations

Phase II Study of 13-cis-Retinoic Acid plus Interferon-α2a in Heavily Pretreated Squamous Carcinoma of the Cervix

1995 • 26 citations

Phase II study of 13-cis-retinoic acid and interferon-α2a in patients with advanced squamous cell lung cancer

1993 • 24 citations

Retinoic Acid Suppresses Human Papillomavirus Type 16 (HPV16)-Mediated Transformation of Human Keratinocytes and Inhibits the Expression of the HPV16 Oncogenes

1994 • 24 citations

Enhancement of cisplatin and etoposide cytotoxicity after all‐trans retinoic‐acid‐induced cellular differentiation of a murine embryonal carcinoma cell line

1993 • 24 citations

Phase II Trial of 13-cis-Retinoic Acid Plus Interferon in Non-Small-Cell Lung Cancer: For the National Cancer Instit ute of Canada Clinical Trials Group

1994 • 24 citations

Phase II trial of 13-cis-retinoic acid plus interferon-α in recurrent head and neck cancer

1993 • 23 citations

Phase II study of alpha-interferon and 13-cis-retinoic acid in metastatic melanoma

1993 • 23 citations

The AF-2 Region of the Retinoic Acid Receptor α Mediates Retinoic Acid Inhibition of Estrogen Receptor Function in Breast Cancer Cells

1996 • 20 citations

Cellular Biology of the Retinoids

1995 • 18 citations

The effect of retinoic acid on chemosensitivity of PA‐1 human teratocarcinoma cells and its modulation by an activated N‐ras oncogene

1992 • 17 citations

Different points of action of retinoids and anti-estrogens in G1 phase identified in synchronized T-47D breast cancer cells

1997 • 12 citations

RETINOIC ACID RECEPTOR-GAMMA-SELECTIVE RETINOIDS EXERT ANTIPROLIFERATIVE EFFECTS ON HUMAN-MELANOMA CELL-GROWTH IN-VITRO

1994 • 12 citations

A phase II trial of a differentiating agent (tRA) with cisplatin-VP 16 chemotherapy in advanced non-small cell lung cancer

1996 • 10 citations

Biology and reversal of aerodigestive tract carcinogenesis

1995 • 5 citations