Cellular Biology of the Retinoids

Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.

1980 • 1,997 citations

The retinoids—Biology, chemistry and medicine

1996 • 1,192 citations

Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells

1980 • 1,094 citations

The Retinoids-Biology, Chemistry and Medicine

1994 • 987 citations

Retinoids and their receptors in differentiation, embryogenesis, and neoplasia

1991 • 856 citations

Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro

1984 • 808 citations

Hormonal induction of differentiation in teratocarcinoma stem cells: Generation of parietal endoderm by retinoic acid and dibutyryl cAMP

1980 • 803 citations

Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line

1982 • 674 citations

Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma

1985 • 644 citations

Retinoic acid is a negative regulator of AP-1-responsive genes.

1991 • 542 citations

Retinoids in cancer therapy.

1992 • 505 citations

HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis

1990 • 390 citations

Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site.

1990 • 377 citations

Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells

1993 • 332 citations

Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).

1990 • 330 citations

Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers.

1989 • 260 citations

N-(4-hydroxyphenyl)retinamide induces apoptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acid.

1993 • 249 citations

Inhibition of angiogenesis through modulation of collagen metabolism.

1988 • 240 citations

HOX gene activation by retinoic acid

1991 • 211 citations

Retinoids in Normal Development and Teratogenesis

1992 • 170 citations

Expression of a drug resistance gene in human neuroblastoma cell lines: modulation by retinoic acid-induced differentiation.

1989 • 162 citations

Retinoids, retinoid-responsive genes, cell differentiation, and cancer.

1992 • 158 citations

Inhibition by retinoic acid of type IV collagenolysis and invasion through reconstituted basement membrane by metastatic rat mammary adenocarcinoma cells.

1989 • 151 citations

c-myc regulation during retinoic acid-induced differentiation of F9 cells is posttranscriptional and associated with growth arrest.

1986 • 147 citations

A highly potent antiangiogenic activity of retinoids

1989 • 143 citations

A dominant negative mutation of the alpha retinoic acid receptor gene in a retinoic acid-nonresponsive embryonal carcinoma cell.

1990 • 134 citations

Retinoic acid inhibition of human melanoma cell invasion through a reconstituted basement membrane and its relation to decreases in the expression of proteolytic enzymes and motility factor receptor.

1990 • 126 citations

Retinoic acid-induced differentiation of the developmentally pluripotent human germ cell tumor-derived cell line, NCCIT.

1993 • 124 citations

Phenotype‐specific “tissue” transglutaminase regulation in human neuroblastoma cells in response to retinoic acid: Correlation with cell death by apoptosis

1992 • 119 citations

Differentiation of cultured human breast cancer cells (AU‐565 and MCF‐7) associated with loss of cell surface HER‐2/neu antigen

1990 • 115 citations

Inhibition of human melanoma colony formation by retinoids.

1979 • 114 citations

Retinoid Modulation of Insulin-Like Growth Factor-Binding Proteins and Inhibition of Breast Carcinoma Proliferation*

1991 • 110 citations

Increased expression of protein kinase C alpha plays a key role in retinoic acid-induced melanoma differentiation.

1992 • 109 citations

Different patterns of glycolipid antigens are expressed following differentiation of TERA-2 human embryonal carcinoma cells induced by retinoic acid, hexamethylene bisacetamide (HMBA) or bromodeoxyuridine (BUdR)

1990 • 105 citations

Retinoid‐enhanced gap junctional communication is achieved by increased levels of connexin 43 mRNA and protein

1990 • 101 citations

Up-regulation of the integrin alpha 1/beta 1 in human neuroblastoma cells differentiated by retinoic acid: correlation with increased neurite outgrowth response to laminin.

1991 • 97 citations

Induction of transforming growth factor-beta 1 (TGF-beta 1), receptor expression and TGF-beta 1 protein production in retinoic acid-treated HL-60 cells: possible TGF-beta 1-mediated autocrine inhibition

1991 • 95 citations

Mechanistic interrelationships between two superfamilies: the steroid/retinoid receptors and transforming growth factor-beta.

1992 • 90 citations

Interaction of Retinoids and Tamoxifen on the Inhibition of Human Mammary Carcinoma Cell Proliferation

1987 • 84 citations

Combinations of retinoic acid with either sodium butyrate, dimethyl sulfoxide, or hexamethylene bisacetamide synergistically induce differentiation of the human myeloid leukemia cell line HL60.

1990 • 84 citations

Retinoic acid receptor expression vector inhibits differentiation of F9 embryonal carcinoma cells.

1989 • 79 citations

Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells.

1993 • 76 citations

Increased sensitivity of human keratinocytes immortalized by human papillomavirus type 16 DNA to growth control by retinoids.

1992 • 72 citations

Nuclear receptors for retinoids: mediators of retinoid effects on normal and malignant cells

1991 • 68 citations

Retinoic acid‐induced differentiation of the human promyelocytic leukemia cell line, HL‐60, and fresh human leukemia cells in primary culture: A model for differentiation inducing therapy of leukemia

1987 • 65 citations

Control of squamous differentiation in tracheobronchial and epidermal epithelial cells: role of retinoids.

1992 • 63 citations

Induction of transforming growth factor-beta 1 (TGF-beta 1), receptor expression and TGF-beta 1 protein production in retinoic acid-treated HL-60 cells: possible TGF-beta 1-mediated autocrine inhibition

1991 • 63 citations

Modulation by Retinoids of mRNA Levels for Nuclear Retinoic Acid Receptors in Murine Melanoma Cells

1990 • 61 citations

Transcriptional control of epidermal growth factor receptor by retinoic acid.

1992 • 61 citations

The expression of multiple proto-oncogenes is differentially regulated during retinoic acid induced maturation of human neuroblastoma cell lines.

1988 • 58 citations

Induction of expression of the alpha v beta 1 and alpha v beta 3 integrin heterodimers during retinoic acid-induced neuronal differentiation of murine embryonal carcinoma cells.

1991 • 58 citations

Responses to retinoic acid of tamoxifen-sensitive and -resistant sublines of human breast cancer cell line MCF-7.

1992 • 56 citations

Retinoid antagonism of estrogen-responsive transforming growth factor alpha and pS2 gene expression in breast carcinoma cells.

1992 • 53 citations

Regulation of insulin-like growth factor I production in rat C6 glioma cells: possible role as an autocrine/paracrine growth factor.

1992 • 52 citations

Induction of tissue transglutaminase and apoptosis by retinoic acid in the limb bud

1992 • 50 citations

Regulation by retinoic acid of ICAM-1 expression on human tumor cell lines

1991 • 49 citations

Expression of retinoic acid receptor-alpha mRNA in human leukemia cells with variable responsiveness to retinoic acid.

1989 • 49 citations

Retinoic acid negatively regulates p34cdc2 expression during human neuroblastoma differentiation.

1991 • 48 citations

Retinoic acid causes a decline in TGF-alpha expression, cloning efficiency, and tumorigenicity in a human embryonal cancer cell line.

1990 • 48 citations

Inhibition of tumor cell growth by retinoids

1990 • 47 citations

Inhibition of proliferation by retinoids, cytokines and their combination in four human transformed epithelial cell lines

1992 • 43 citations

Recombinant human interferon sensitizes resistant myeloid leukemic cells to induction of terminal differentiation

1985 • 43 citations

Effect of 13‐cis‐retinoic acid and 4‐hydroxyphenyl‐all‐trans‐retinamide on human tumor colony formation in soft agar

1983 • 42 citations

Modulation of IGF-2 expression during growth and differentiation of human neuroblastoma cells: Retinoic acid may induce IGF-2

1993 • 38 citations

Increased PKA and PKC activities accompany neuronal differentiation of NT2/D1 cells

1991 • 38 citations

Retinoids in oncology

1993 • 37 citations

Enhancement by retinoic acid and dibutyryl cyclic adenosine 3':5'-monophosphate of the differentiation and gene expression of human neuroblastoma cells induced by interferon.

1991 • 36 citations

Isolation and analysis of melanoma cell mutants resistant to the antiproliferative action of retinoic acid.

1983 • 35 citations

Comparison of retinoic acid effects on anchorage-dependent growth, anchorage-independent growth and fibrinolytic activity of neoplastic cells

1982 • 30 citations

Growth inhibitory and stimulatory effects of retinoic acid on murine 3T3 cells.

1982 • 29 citations

The Regulation of the Expression of Genes Encoding Basement Membrane Proteins during the Retinoic Acid‐Associated Differentiation of Murine Teratocarcinoma Cells^a

1990 • 29 citations

Expression of protein kinase C‐alpha (PKC‐α) and MYCN mRNAs in human neuroblastoma cells and modulation during morphological differentiation induced by retinoic acid

1991 • 29 citations

Inhibition of epidermal growth factor receptor activity by retinoic acid in glioma cells

1990 • 28 citations

The effects of retinoic acid on the In Vitro and In Vivo growth of neuroblastoma cells

1992 • 27 citations

Retinoid receptor antisense DNAs inhibit alkaline phosphatase induction and clonogenicity in malignant keratinocytes.

1989 • 27 citations

Suppression of melanoma cell motility factor receptor expression by retinoic acid.

1992 • 27 citations

9-cis and all-trans retinoic acid induce a similar phenotype in human teratocarcinoma cells

1993 • 26 citations

Regulation of insulin-like growth factor I production in rat C6 glioma cells: possible role as an autocrine/paracrine growth factor

1992 • 25 citations

Enhancement of cisplatin and etoposide cytotoxicity after all‐trans retinoic‐acid‐induced cellular differentiation of a murine embryonal carcinoma cell line

1993 • 24 citations

Inhibition of mitogen-induced c-fos expression in melanoma cells by retinoic acid involves the serum response element.

1992 • 22 citations

Activation of the human mdr1 gene promoter in differentiated neuroblasts

1993 • 20 citations

HOX gene activation by retinoic acid

1991 • 20 citations

Ex vivo differentiation therapy as a method of leukemic cell purging in murine bone marrow expansion cultures.

1992 • 17 citations

Use of a human tumor cloning system to screen retinoids for antineoplastic activity

1983 • 16 citations

B16 mouse melanoma cells selected for resistance to cyclic AMP‐mediated growth inhibition are cross‐resistant to retinoic acid‐induced growth inhibition

1991 • 15 citations

Modulation of differentiation in PA-1 human teratocarcinoma cells after N-ras oncogene-induced tumorigenicity.

1991 • 11 citations

Modulation by all-trans retinoic acid of glycoprotein glycosylation in murine melanoma cells: enhancement of fucosyl- and galactosyltransferase activities.

1990 • 11 citations

45. Regulation of BcI-2 and cell death by all-trans retinoic acid in acute promyelocytic leukemic cells

1992 • 10 citations

Human papillomavirus-immortalized keratinocytes are resistant to the effects of retinoic acid on terminal differentiation.

1993 • 10 citations

Chemically induced differentiation of murine embryonal carcinoma in vivo: transplantation of differentiated tumors.

1984 • 10 citations

Retinoic‐acid‐induced differentiation prevents gene amplification in teratocarcinoma stem cells

1991 • 9 citations

Selective isolation of human breast carcinoma cells resistant to the growth‐inhibitory effects of retinol

1990 • 9 citations

Effects of dietary retinoids upon growth and differentiation of tumors derived from several murine embryonal carcinoma cell lines.

1988 • 9 citations

Retinoid-regulated expression of transglutaminases: links to the biochemistry of programmed cell death

1992 • 6 citations

Inhibitory Effects of Retinoids on Tumor Cell Invasion and Metastasis

1992 • 6 citations