The AF-2 Region of the Retinoic Acid Receptor α Mediates Retinoic Acid Inhibition of Estrogen Receptor Function in Breast Cancer Cells

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Textbook of Endocrinology

1952 • 1,475 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.

1995 • 756 citations

An estrogen-responsive element derived from the 5′ flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells

1986 • 729 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription

1993 • 668 citations

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

1994 • 645 citations

The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors

1991 • 603 citations

Steroid hormone receptors compete for factors that mediate their enhancer function

1989 • 580 citations

Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid

1981 • 566 citations

Retinoic acid is a negative regulator of AP-1-responsive genes.

1991 • 542 citations

Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene.

1990 • 487 citations

A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells

1986 • 408 citations

Interaction of proteins with transcriptionally active estrogen receptors.

1994 • 379 citations

Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7.

1984 • 379 citations

Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.

1994 • 354 citations

Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

1992 • 341 citations

Two human homologues ofSaccharomyces cerevisiae SWI2/SNF2andDrosophila brahmaare transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor

1994 • 338 citations

Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor.

1994 • 324 citations

Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7

1984 • 304 citations

Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors.

1993 • 207 citations

A dominant negative mutation of the alpha retinoic acid receptor gene in a retinoic acid-nonresponsive embryonal carcinoma cell.

1990 • 134 citations

Retinoic acid resistance of estradiol-independent breast cancer cells coincides with diminished retinoic acid receptor function

1993 • 126 citations

On the mechanism of DNA binding by nuclear hormone receptors: A structural and functional perspective

1993 • 125 citations

Textbook of Endocrinology

1950 • 120 citations

Retinoid-resistant estrogen receptor-negative human breast carcinoma cells transfected with retinoic acid receptor-alpha acquire sensitivity to growth inhibition by retinoids.

1994 • 109 citations

The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon.

1989 • 107 citations

Retinoid Receptors

1993 • 88 citations

Antiestrogenic effects of all-trans-retinoic acid and 1,25-dihydroxyvitamin D3 in breast cancer cells occur at the estrogen response element level but through different molecular mechanisms.

1994 • 80 citations

Inhibition of estrogen-responsive gene activation by the retinoid X receptor beta: evidence for multiple inhibitory pathways.

1993 • 79 citations

Retinoic acid acts synergistically with 1,25-dihydroxyvitamin D3 or antioestrogen to inhibit T-47D human breast cancer cell proliferation

1991 • 68 citations

Progesterone receptor regulation by retinoic acid in the human breast cancer cell line T-47D.

1990 • 59 citations

Retinoid antagonism of estrogen-responsive transforming growth factor alpha and pS2 gene expression in breast carcinoma cells.

1992 • 53 citations

The effects of retinoids on proliferative capacities and macromolecular synthesis in human breast cancer MCF-7 cells

1980 • 52 citations

Distinct binding determinants for 9-cis retinoic acid are located within AF-2 of retinoic acid receptor alpha.

1994 • 52 citations

Direct transcriptional regulation of the progesterone receptor by retinoic acid diminishes progestin responsiveness in the breast cancer cell line T-47D.

1991 • 46 citations

Alteration of a single amino acid residue in retinoic acid receptor causes dominant-negative phenotype.

1994 • 46 citations

Retinoic acid inhibition of human breast carcinoma proliferation is accompanied by inhibition of the synthesis of a Mr 39,000 protein.

1990 • 45 citations

Differential regulation of AP1 activity by retinoic acid in hormone-dependent and -independent breast cancer cells

1995 • 37 citations

Study of an antiestrogenic effect of retinoic acid in MCF-7 cells

1992 • 29 citations

Mutagenesis of the Ligand Binding Domain of the Human Retinoic Acid Receptor α Identifies Critical Residues for 9-cis-Retinoic Acid Binding

1995 • 24 citations

Inhibition of mitogen-induced c-fos expression in melanoma cells by retinoic acid involves the serum response element.

1992 • 22 citations

Affinity labelling and cloning of steroid and thyroid hormone receptors

1990 • 13 citations

Pretreatment with vitamin A inhibits transforming growth factor alpha stimulation of human mammary carcinoma cells

1993 • 10 citations