Differential induction of apoptosis by all-trans-retinoic acid and N-(4-hydroxyphenyl)retinamide in human head and neck squamous cell carcinoma cell lines.

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Molecular regulation of apoptosis: Genetic controls on cell death

1993 • 923 citations

13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia

1986 • 825 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

1992 • 685 citations

The retinoid receptors.

1994 • 665 citations

The retinoid signaling pathway: molecular and genetic analyses

1994 • 508 citations

HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis

1990 • 390 citations

N-(4-Hydroxyphenyl)retinamide, a new retinoid for prevention of breast cancer in the rat.

1979 • 388 citations

Apoptosis and cancer chemotherapy

2001 • 296 citations

Cell Death by Apoptosis in Epidermal Biology

1993 • 296 citations

Condensation of the chromatin at the membrane of an apoptotic nucleus is not associated with activation of an endonuclease

1993 • 279 citations

Oncogenes and cell death

1994 • 266 citations

N-(4-hydroxyphenyl)retinamide induces apoptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acid.

1993 • 249 citations

Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.

1992 • 225 citations

Delayed internucleosomal DNA fragmentation in programmed cell death

1993 • 222 citations

Randomized placebo-controlled trial of isotretinoin in chemoprevention of bronchial squamous metaplasia.

1994 • 220 citations

Differential expression of nuclear retinoid receptors in normal, premalignant, and malignant head and neck tissues.

1994 • 218 citations

Five-year administration of fenretinide: pharmacokinetics and effects on plasma retinol concentrations.

1993 • 205 citations

Differential effects of N-(4-hydroxyphenyl)retinamide and retinoic acid on neuroblastoma cells: apoptosis versus differentiation.

1995 • 195 citations

The expression of "tissue" transglutaminase in two human cancer cell lines is related with the programmed cell death (apoptosis).

1991 • 183 citations

Apoptosis in C3H/10T1/2 mouse embryonic cells: evidence for internucleosomal DNA modification in the absence of double-strand cleavage.

1993 • 181 citations

Prevention of primary prostate cancer in Lobund-Wistar rats by N-(4-hydroxyphenyl)retinamide.

1991 • 178 citations

Human Squamous Cell Carcinoma: Establishment and Characterization of New Permanent Cell Lines

1981 • 174 citations

Establishment and characterization of two new squamous cell carcinoma cell lines derived from tumors of the head and neck.

1988 • 156 citations

Treatment of prostate cancer in the rat with the synthetic retinoid fenretinide.

1993 • 155 citations

Demonstration of extensive chromatin cleavage in transplanted Morris hepatoma 7777 tissue: apoptosis or necrosis?

1993 • 141 citations

Synthetic retinoid fenretinide is effective against a human ovarian carcinoma xenograft and potentiates cisplatin activity.

1993 • 134 citations

Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: Effects of Ca2+-endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death

1992 • 127 citations

Chemopreventive efficacy of combined retinoid and tamoxifen treatment following surgical excision of a primary mammary cancer in female rats.

1989 • 126 citations

Phenotype‐specific “tissue” transglutaminase regulation in human neuroblastoma cells in response to retinoic acid: Correlation with cell death by apoptosis

1992 • 119 citations

Prospects of chemoprevention of human cancers with the synthetic retinoid fenretinide.

1994 • 117 citations

Apoptosis in the genesis and prevention of cancer.

1992 • 101 citations

Modulation by retinoic acid (RA) of squamous cell differentiation, cellular RA-binding proteins, and nuclear RA receptors in human head and neck squamous cell carcinoma cell lines.

1994 • 88 citations

Successful topical treatment of oral lichen planus and leukoplakias with fenretinide (4-HPR)

1994 • 82 citations

Retinoid-sensitive cells and cell lines

1990 • 80 citations

Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents.

1990 • 78 citations

Chemoprevention of experimental carcinogenesis in animals

1989 • 68 citations

Nuclear receptors for retinoids: mediators of retinoid effects on normal and malignant cells

1991 • 68 citations

N-(4-hydroxyphenyl)retinamide: a Potent Inducer of Apoptosis in Human Neuroblastoma Cells

1994 • 65 citations

Characterization of human laryngeal primary and metastatic squamous cell carcinoma cell lines UM-SCC-17A and UM-SCC-17B.

1989 • 63 citations

Modulation of the Terminal Differentiation of Human Squamous Carcinoma Cells In Vitro by <italic>all-trans</italic>-Retinoic Acid<xref ref-type="fn" rid="FN2">2</xref>

1985 • 61 citations

Induction of tissue transglutaminase and apoptosis by retinoic acid in the limb bud

1992 • 50 citations

Suppression of rat mammary cancer development by N-(4-hydroxy-phenyDretinamide (4-HPR) following surgical removal of first palpable tumor

1989 • 46 citations

Differential expression of transglutaminase in human erythroleukemia cells in response to retinoic acid.

1990 • 43 citations

Therapeutic effect of N-(4-hydroxyphenyl)retinamide on N-methyl-N-nitrosourea-induced rat mammary cancer

1989 • 43 citations

Effect of 13‐cis‐retinoic acid and 4‐hydroxyphenyl‐all‐trans‐retinamide on human tumor colony formation in soft agar

1983 • 42 citations

Marked apoptosis of human myelomonocytic leukemia cell line P39: significance of cellular differentiation.

1994 • 36 citations

Squamous cell differentiation markers in normal, premalignant, and malignant epithelium: Effects of retinoids

1993 • 32 citations

Effects of β‐all‐trans retinoic acid on growth, proliferation, and cell death in a multicellular tumor spheroid model for squamous carcinomas

1990 • 28 citations

Breast cancer chemoprevention: Studies with 4-HPR alone and in combination with tamoxifen using circulating growth factors as potential surrogate endpoints

1993 • 27 citations

Evidence that retinoic acid-induced apoptosis in the mouse limb bud core mesenchymal cells is gene-mediated.

1993 • 24 citations

45. Regulation of BcI-2 and cell death by all-trans retinoic acid in acute promyelocytic leukemic cells

1992 • 10 citations

In Vitro Photosensitization of Human Head and Neck Squamous Cancer Cells by Dihematoporphyrin‐Ether

1988 • 7 citations