Role of Bcl‐2 family of proteins in malignancy

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

1984 • 1,761 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1999 • 1,540 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

2000 • 1,427 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

Apoptosis Signaling

2000 • 1,290 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

Structure of Bax

2000 • 1,066 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

Genetic Control of Programmed Cell Death in Drosophila

1994 • 1,028 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

Role ofBAXin the Apoptotic Response to Anticancer Agents

2000 • 854 citations

An evolutionary perspective on apoptosis

1994 • 758 citations

Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

1999 • 717 citations

Bax Is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells

2001 • 676 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

1998 • 641 citations

The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9

1998 • 628 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

2001 • 546 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

1997 • 489 citations

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

2000 • 487 citations

Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling

1999 • 473 citations

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

2001 • 445 citations

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

1993 • 402 citations

Solution Structure of the Proapoptotic Molecule BID

1999 • 387 citations

The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review

1999 • 375 citations

Electrophysiological Study of a Novel Large Pore Formed by Bax and the Voltage-dependent Anion Channel That Is Permeable to Cytochrome c

2000 • 335 citations

Apoptosis regulator Bcl-w is essential for spermatogenesis but appears otherwise redundant

1998 • 333 citations

The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol

1999 • 316 citations

Bcl-2 family proteins as ion-channels

1998 • 299 citations

Hematopoietic Malignancies Demonstrate Loss-of-Function Mutations ofBAX

1998 • 291 citations

Testicular degeneration in Bclw-deficient mice

1998 • 263 citations

How BAD phosphorylation is good for survival

1999 • 242 citations

Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution

2000 • 234 citations

Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell.

1989 • 216 citations

Mechanisms mediating caspase activation in cell death

1999 • 208 citations

Accelerated Neutrophil Apoptosis in Mice Lacking A1-a, a Subtype of the bcl-2–related A1 Gene

1998 • 198 citations

The fight of viruses against apoptosis

1998 • 177 citations

Debcl, a Proapoptotic Bcl-2 Homologue, Is a Component of the Drosophila melanogaster Cell Death Machinery

2000 • 168 citations

Cell permeable Bcl-2 binding peptides: a chemical approach to apoptosis induction in tumor cells.

2000 • 167 citations

E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.

1993 • 162 citations

The ICE family of cysteine proteases as effectors of cell death.

1996 • 158 citations

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

1999 • 157 citations

Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid

1999 • 148 citations

The fly caspases

2000 • 146 citations

Pro-Apoptotic Apoptosis Protease–Activating Factor 1 (Apaf-1) Has a Cytoplasmic Localization Distinct from Bcl-2 or Bcl-XL

2000 • 142 citations

Bcl-2 and Bax mammalian regulators of apoptosis are functional in Drosophila

2000 • 126 citations

Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide.

2000 • 107 citations

Prodomains – adaptors – oligomerization: the pursuit of caspase activation in apoptosis

1999 • 103 citations

Microtubule-Targeting Drugs Induce Bcl-2 Phosphorylation and Association with Pin1

2001 • 94 citations

Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice

1995 • 92 citations

Regulation and execution of apoptosis duringDrosophila development

2000 • 77 citations

Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine

2000 • 77 citations

Human Bcl-2 antisense therapy for lymphomas

1999 • 60 citations

Expression of bcl‐2 and bax in cellsisolated from B‐chronic lymphocytic leukemia patients at differentstages of the disease

2000 • 29 citations

Pleiotropic drug resistance in B-cell chronic lymphocytic leukaemia — the role of Bcl-2 family dysregulation

1999 • 29 citations

Cloning and Characterization of a Novel Nuclear Bcl-2 Family Protein, zfMcl-1a, in Zebrafish Embryo

2000 • 28 citations

In vitro down-regulation of bcl-2 expression by all-trans retinoic acid in AML blasts

1997 • 28 citations

Prevention of Neuronal Cell Death by Bcl-2

1998 • 9 citations