Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

High gradient magnetic cell separation with MACS

1990 • 1,648 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy

1993 • 738 citations

Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.

1996 • 662 citations

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

1997 • 502 citations

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

1992 • 487 citations

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.

1995 • 477 citations

Immunohistochemical analysis of in vivo patterns of Bcl-X expression.

1994 • 429 citations

Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells.

1995 • 422 citations

Low molecular weight heparins: prophylaxis of venous thromboembolism in surgical patients.

1997 • 399 citations

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.

1996 • 376 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

1998 • 360 citations

Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

1996 • 344 citations

The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

1997 • 343 citations

Hematopoietic Malignancies Demonstrate Loss-of-Function Mutations ofBAX

1998 • 291 citations

Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death.

1996 • 284 citations

Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis.

1993 • 275 citations

bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair.

1993 • 218 citations

c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle.

1994 • 210 citations

Randomized Phase II Study of Fludarabine + Cytosine Arabinoside + Idarubicin ± All-Trans Retinoic Acid ± Granulocyte Colony-Stimulating Factor in Poor Prognosis Newly Diagnosed Acute Myeloid Leukemia and Myelodysplastic Syndrome

1999 • 202 citations

Diminished Cell Proliferation Associated with the Death-protective Activity of Bcl-2

1996 • 202 citations

Sensitive detection and enumeration of CD34+ cells in peripheral and cord blood by flow cytometry.

1994 • 201 citations

Overexpression of Bcl-XS sensitizes MCF-7 cells to chemotherapy-induced apoptosis.

1995 • 200 citations

Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice.

1996 • 192 citations

Reversal of Chemoresistance of Lymphoma Cells by Antisense-Mediated Reduction ofbcl-2 Gene Expression

1994 • 190 citations

The relationship between bcl‐2 expression and response to chemotherapy in acute leukaemia

1994 • 165 citations

Effects of BCL-2 antisense oligodeoxynucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells

1994 • 162 citations

The p53-Binding Protein 53BP2 Also Interacts with Bcl2 and Impedes Cell Cycle Progression at G₂/M

1996 • 159 citations

High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia

1998 • 159 citations

Androgens induce resistance to bcl-2-mediated apoptosis in LNCaP prostate cancer cells.

1995 • 154 citations

Apoptosis

1999 • 140 citations

High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells.

1994 • 128 citations

Liposomal Bcl-2 antisense oligonucleotides enhance proliferation, sensitize acute myeloid leukemia to cytosine-arabinoside, and induce apoptosis independent of other antiapoptotic proteins

2000 • 110 citations

Primitive human hematopoietic precursors express Bcl-x but not Bcl-2

1995 • 104 citations

Cloning and sequencing of a cDNA encoding the rat Bcl-2 protein

1994 • 100 citations

Bcl-2 protein expression in normal human bone marrow precursors and in acute myelogenous leukemia.

1995 • 98 citations

Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7.

1998 • 94 citations

Association of bcl-2, bax, bcl-xL and interleukin-1 beta-converting enzyme expression with initial response to chemotherapy in acute myeloid leukemia.

1996 • 92 citations

Comparative quantitative expression of bcl‐2 by normal and leukaemic myeloid cells

1995 • 46 citations

Minimal residual disease in acute myelogenous leukaemia and myelodysplastic syndromes: a follow‐up of patients in clinical remission

1997 • 28 citations

Regulatory pathways in programmed cell death

1999 • 5 citations