Prevention of Neuronal Cell Death by Bcl-2

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Identification and characterization of a spinal muscular atrophy-determining gene

1995 • 3,722 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

1996 • 1,027 citations

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

1995 • 976 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development

1996 • 745 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1994 • 590 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

1993 • 586 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

1995 • 514 citations

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

1995 • 501 citations

Muscle Disorders in Childhood

2015 • 491 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins

1994 • 467 citations

Bcl-2 promotes regeneration of severed axons in mammalian CNS

1997 • 449 citations

Upregulation of bax protein levels in neurons following cerebral ischemia

1995 • 440 citations

bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS

1994 • 432 citations

Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

1995 • 431 citations

Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

1998 • 414 citations

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry.

1996 • 384 citations

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-XL

1997 • 381 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

ICE-like proteases in apoptosis

1995 • 353 citations

Ultrastructural localization of bcl-2 protein.

1992 • 351 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors

1996 • 321 citations

HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.

1996 • 318 citations

bcl-w, a novel member of the bcl-2 family, promotes cell survival.

1996 • 309 citations

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

1997 • 304 citations

Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors.

1996 • 300 citations

Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes.

1994 • 290 citations

bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death.

1995 • 289 citations

Identification of a novel regulatory domain in Bcl-xL and Bcl-2

1997 • 287 citations

Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death.

1996 • 284 citations

Inactivation of bcl-2 Results in Progressive Degeneration of Motoneurons, Sympathetic and Sensory Neurons during Early Postnatal Development

1996 • 263 citations

bcl-2 transgene expression can protect neurons against developmental and induced cell death.

1995 • 261 citations

Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions.

1996 • 260 citations

Bcl-2 expression prevents activation of the ICE protease cascade.

1996 • 254 citations

Role of chromosome translocations in human neoplasia

1987 • 226 citations

Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis.

1994 • 222 citations

Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell.

1989 • 216 citations

Expression of bcl‐2 inhibits necrotic neural cell death

1995 • 216 citations

Motoneuron death after sciatic nerve section in newborn rats

1984 • 213 citations

Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease

1995 • 205 citations

Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy

1997 • 202 citations

Diminished Cell Proliferation Associated with the Death-protective Activity of Bcl-2

1996 • 202 citations

Axotomy‐induced neuronal death during development

1992 • 198 citations

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

1995 • 193 citations

Paradoxical inhibition of solid tumor cell growth by bcl2.

1994 • 190 citations

A Clinician's View of Neuromuscular Diseases

1978 • 189 citations

A New Mouse Mutant with Progressive Motor Neuronopathy

1991 • 179 citations

Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+.

1996 • 164 citations

Up-regulation of bax and down-regulation of bc1–2 is associated with kainate-induced apoptosis in mouse brain

1995 • 164 citations

Long‐term Survival of Retina Optic Nerve Section in Adult Ganglion Cells Following bcl‐2 Transgenic Mice

1996 • 147 citations

Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase.

1996 • 144 citations

Regeneration in the adult mammalian CNS: guided by development

1995 • 129 citations

bcl-2 Gene Is Highly Expressed during Neurogenesis in the Central Nervous System

1993 • 109 citations

The gene located at chromosome 18 band q21 is rearranged in uncultured diffuse lymphomas as well as follicular lymphomas

1987 • 105 citations

Immunohistochemical detection of Bax and Bcl-2 proteins in gerbil hippocampus following transient forebrain ischemia

1996 • 103 citations

Bcl-2 inhibits hydrogen peroxide-induced ER Ca2+ pool depletion.

1996 • 100 citations

Intermediate- to high-grade histology of lymphomas carrying t(14;18) is associated with additional nonrandom chromosome changes

1987 • 98 citations

The effect of age on motor neurone death following axotomy in the mouse

1991 • 92 citations

Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors

1996 • 91 citations

Function and expression of the Bcl-x gene in the developing and adult nervous system

1995 • 91 citations

Deletion of a nonconserved region of Bcl-2 confers a novel gain of function: suppression of apoptosis with concomitant cell proliferation.

1996 • 65 citations

Unmasking of a proliferation-restraining activity of the anti-apoptosis protein EBV BHRF1.

1996 • 56 citations

Susceptibility of Cerebellar Granule Neurons Derived from Bcl‐2‐Deficient and Transgenic Mice to Cell Death

1997 • 52 citations

Bcl-2 Overexpression Abolishes Early Calcium Waving Preceding Apoptosis in NIH-3T3 Murine Fibroblasts

1994 • 47 citations

Bcl-2 Sensitivity Differentiates Two Pathways for Motoneuronal Death in thewobblerMutant Mouse

1996 • 39 citations

Cytogenetic 2; 18 and 18; 22 translocation in chronic lymphocytic leukemia with juxtaposition of bcl-2 and immunoglobulin light chain genes.

1992 • 36 citations

A Clinician's View of Neuromuscular Diseases

1986 • 30 citations

The motoneuron degeneration in the wobbler mouse is independent of the overexpression of a Bcl2 transgene in neurons

1995 • 18 citations