Bax Is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells

Mitochondria and Apoptosis

1998 • 8,909 citations

The biochemistry of apoptosis

2000 • 7,314 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Solubilization of membranes by detergents

1975 • 2,909 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

Structure of Bax

2000 • 1,066 citations

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

2000 • 1,046 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

1999 • 717 citations

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

1999 • 659 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

1998 • 641 citations

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

2000 • 619 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Nonionic Detergents Induce Dimerization among Members of the Bcl-2 Family

1997 • 583 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations

1998 • 508 citations

Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death

1999 • 495 citations

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

1995 • 491 citations

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

1997 • 489 citations

Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis

1999 • 485 citations

Cyclophilin‐D binds strongly to complexes of the voltage‐dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore

1998 • 475 citations

Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling

1999 • 473 citations

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

2000 • 447 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

Solution Structure of the Proapoptotic Molecule BID

1999 • 387 citations

Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition

1998 • 381 citations

Bax cleavage is mediated by calpain during drug-induced apoptosis

1998 • 330 citations

BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity

1997 • 302 citations

Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution

1997 • 251 citations

The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis.

1994 • 186 citations

A Peptide Sequence from Bax That Converts Bcl-2 into an Activator of Apoptosis

1996 • 111 citations

Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis

1999 • 108 citations

Apoptosis: Bcl-2-related proteins get connected

1997 • 100 citations

Techniques in lipid and membrane biochemistry

1984 • 52 citations

Bcl-2 is a monomeric protein: prevention of homodimerization by structural constraints

2000 • 44 citations

Expression and Purification of Full-Length Human Bax α

1999 • 40 citations

Bcl-2 prevents activation of CPP32 cysteine protease and cleavage of poly (ADP-ribose) polymerase and U1-70 kD proteins in staurosporine-mediated apoptosis

1997 • 34 citations

The mitochondrial ATP / ADP carrier: Interaction with detergents and purification by a novel procedure

1994 • 17 citations