Mechanisms mediating caspase activation in cell death

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Caspases: killer proteases

1997 • 2,440 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

1998 • 1,132 citations

An Induced Proximity Model for Caspase-8 Activation

1998 • 1,030 citations

Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB

1999 • 725 citations

Bcl10 Is Involved in t(1;14)(p22;q32) of MALT B Cell Lymphoma and Mutated in Multiple Tumor Types

1999 • 666 citations

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

1994 • 567 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

The CARD domain: a new apoptotic signalling motif

1997 • 532 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Cytochrome c and dATP-mediated Oligomerization of Apaf-1 Is a Prerequisite for Procaspase-9 Activation

1999 • 502 citations

Caspase-9 Can Be Activated without Proteolytic Processing

1999 • 498 citations

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

1999 • 449 citations

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

1996 • 434 citations

Autoproteolytic Activation of Pro-Caspases by Oligomerization

1998 • 424 citations

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

1999 • 415 citations

The domains of death: evolution of the apoptosis machinery

1999 • 406 citations

THE CENTRAL EFFECTORS OF CELL DEATH IN THE IMMUNE SYSTEM

1999 • 390 citations

Human CARD4 Protein Is a Novel CED-4/Apaf-1 Cell Death Family Member That Activates NF-κB

1999 • 363 citations

ICE-like proteases in apoptosis

1995 • 353 citations

ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases

1998 • 350 citations

Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway

1999 • 329 citations

Identification of CARDIAK, a RIP-like kinase that associates with caspase-1

1998 • 316 citations

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

1997 • 316 citations

Solution Structure of the RAIDD CARD and Model for CARD/CARD Interaction in Caspase-2 and Caspase-9 Recruitment

1998 • 302 citations

Mitochondria and Apoptosis

1999 • 273 citations

WD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 Activation

1998 • 252 citations

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.

1997 • 252 citations

Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone

1997 • 245 citations

The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis

1999 • 238 citations

Death-effector Filaments: Novel Cytoplasmic Structures that Recruit Caspases and Trigger Apoptosis

1998 • 237 citations

NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

1998 • 235 citations

Identification of a Drosophila melanogaster ICE/CED-3-related protease, drICE

1997 • 198 citations

Synthetic activation of caspases: Artificial death switches

1998 • 186 citations

A Caspase-9 Variant Missing the Catalytic Site Is an Endogenous Inhibitor of Apoptosis

1999 • 179 citations

Boo, a novel negative regulator of cell death, interacts with Apaf-1

1999 • 177 citations

Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis.

1999 • 157 citations

Caspase-14 Is a Novel Developmentally Regulated Protease

1998 • 153 citations

Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo.

1995 • 133 citations

mE10, a Novel Caspase Recruitment Domain-containing Proapoptotic Molecule

1999 • 120 citations

Dimerization and Autoprocessing of the Nedd2 (Caspase-2) Precursor Requires both the Prodomain and the Carboxyl-terminal Regions

1998 • 114 citations

Regulation of Apoptotic Protease Activating Factor-1 Oligomerization and Apoptosis by the WD-40 Repeat Region

1999 • 114 citations

Prodomains – adaptors – oligomerization: the pursuit of caspase activation in apoptosis

1999 • 103 citations

Caenorhabditis elegans EGL-1 Disrupts the Interaction of CED-9 with CED-4 and Promotes CED-3 Activation

1998 • 100 citations

Identification of Multiple Caenorhabditis elegansCaspases and Their Potential Roles in Proteolytic Cascades

1998 • 89 citations

Conversion of Procaspase-3 to an Autoactivating Caspase by Fusion to the Caspase-2 Prodomain

1998 • 77 citations

REGULATION OF CASPASE ACTIVATION IN APOPTOSIS: IMPLICATIONS IN PATHOGENESIS AND TREATMENT OF DISEASE

1999 • 61 citations

The Death Inhibitory Molecules CED-9 and CED-4L Use a Common Mechanism to Inhibit the CED-3 Death Protease

1998 • 37 citations

Differential inhibitory effects of CrmA, P35, IAP and three mammalian IAP homologues on apoptosis in NIH3T3 cells following various death stimuli

1997 • 28 citations

RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.

1998 • 5 citations

DECAY, a novel Drosophilacaspase related to mammalian caspase-3 and caspase-7.

2000 • 3 citations