Influence of CD4+CD25+ Regulatory T Cells on Low/High-Avidity CD4+ T Cells following Peptide Vaccination

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

1997 • 1,235 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

Human neoplasms elicit multiple specific immune responses in the autologous host.

1995 • 1,097 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells

2003 • 893 citations

Cancer/testis antigens: an expanding family of targets for cancer immunotherapy

2002 • 851 citations

Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells

2001 • 743 citations

Simultaneous Humoral and Cellular Immune Response against Cancer–Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2–binding Peptide Epitopes

1998 • 728 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

A Survey of the Humoral Immune Response of Cancer Patients to a Panel of Human Tumor Antigens

1998 • 712 citations

Adoptive-cell-transfer therapy for the treatment of patients with cancer

2003 • 656 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands

2004 • 525 citations

CD4⁺CD25⁺ regulatory T cells in patients with gastrointestinal malignancies

2003 • 474 citations

Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells

2004 • 472 citations

Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans

2004 • 446 citations

Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers

2000 • 435 citations

Persistent Toll-like receptor signals are required for reversal of regulatory T cell–mediated CD8 tolerance

2004 • 433 citations

Monitoring CD8 T cell responses to NY-ESO-1: Correlation of humoral and cellular immune responses

2000 • 407 citations

Toll-Dependent Control Mechanisms of CD4 T Cell Activation

2004 • 392 citations

Autoreactive T Cells in Healthy Individuals

2004 • 374 citations

Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters

2004 • 352 citations

Depletion of CD25(+) CD4(+) T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced, CD8(+) T-cell-dependent immune defense of B16 melanoma.

2001 • 223 citations

Survey of naturally occurring CD4 ⁺ T cell responses against NY-ESO-1 in cancer patients: Correlation with antibody responses

2003 • 201 citations

CD4⁺T cell recognition of MHC class II-restricted epitopes from NY-ESO-1 presented by a prevalent HLA DP4 allele: Association with NY-ESO-1 antibody production

2001 • 199 citations

CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients

2005 • 169 citations

CD4⁺CD25⁺T cells responding to serologically defined autoantigens suppress antitumor immune responses

2003 • 168 citations

CD4+CD25+ suppressor lymphocytes in the circulation of patients immunized against melanoma antigens.

2003 • 139 citations

Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells

2005 • 131 citations

Generation of NY-ESO-1-specific CD4+ and CD8+ T cells by a single peptide with dual MHC class I and class II specificities: a new strategy for vaccine design.

2002 • 117 citations

Accelerated chemically induced tumor development mediated by CD4 ⁺ CD25 ⁺ regulatory T cells in wild-type hosts

2005 • 111 citations

Antigen‐specific immunotherapy and cancer vaccines

2003 • 97 citations

Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations

2002 • 88 citations

Adenovirus-transduced dendritic cells stimulate cellular immunity to melanoma via a CD4+ T cell-dependent mechanism

2001 • 83 citations

Distinct Structural TCR Repertoires in Naturally Occurring Versus Vaccine-Induced CD8+ T-Cell Responses to the Tumor-Specific Antigen NY-ESO-1

2005 • 57 citations

International Meeting on Cancer Vaccines

2004 • 52 citations

Monitoring CD4+ T cell responses against viral and tumor antigens using T cells as novel target APC

2003 • 51 citations

IFN-γ enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation

2004 • 36 citations