Phenotypical and functional specialization of FOXP3+ regulatory T cells

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

Regulatory T Cells and Immune Tolerance

2008 • 4,778 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Differentiation of Effector CD4 T Cell Populations

2010 • 3,135 citations

How regulatory T cells work

2008 • 3,048 citations

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

2008 • 2,656 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Disseminated tuberculosis in interferon gamma gene-disrupted mice.

1993 • 1,982 citations

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

2007 • 1,890 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

2007 • 1,816 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

TH-17 cells in the circle of immunity and autoimmunity

2007 • 1,520 citations

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

2008 • 1,438 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

2009 • 1,274 citations

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

2004 • 1,242 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

2007 • 1,181 citations

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

2009 • 1,171 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

2008 • 1,131 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

2009 • 1,098 citations

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

2008 • 1,044 citations

Molecular Mechanisms RegulatinG Th1 Immune Responses

2003 • 1,005 citations

The Biology of Interleukin-2

2007 • 986 citations

Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses

2010 • 960 citations

CD4 ⁺ Regulatory T Cells Control T _H 17 Responses in a Stat3-Dependent Manner

2009 • 934 citations

Regulatory T cells in tumor immunity

2010 • 902 citations

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

2009 • 898 citations

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

2007 • 870 citations

Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

2005 • 825 citations

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

2005 • 783 citations

Type I interferon: friend or foe?

2010 • 776 citations

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

2007 • 775 citations

IL-6: from its discovery to clinical applications

2010 • 771 citations

1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP3

2009 • 738 citations

Regulatory T cells and infection: a dangerous necessity

2007 • 728 citations

Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β

2007 • 704 citations

T-bet Regulates the Terminal Maturation and Homeostasis of NK and Vα14i NKT Cells

2004 • 689 citations

Stability of the Regulatory T Cell Lineage in Vivo

2010 • 675 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

REGULATION OF TH2 DIFFERENTIATION ANDIl4LOCUS ACCESSIBILITY

2006 • 625 citations

Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

2004 • 618 citations

DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27

2007 • 608 citations

Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection

2009 • 563 citations

Preferential Generation of Follicular B Helper T Cells from Foxp3 ⁺ T Cells in Gut Peyer's Patches

2009 • 559 citations

The many paths to asthma: phenotype shaped by innate and adaptive immunity

2010 • 552 citations

Interaction of TNF with TNF Receptor Type 2 Promotes Expansion and Function of Mouse CD4+CD25+ T Regulatory Cells

2007 • 509 citations

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo

2006 • 502 citations

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

2009 • 495 citations

Heterogeneity of natural Foxp3 ⁺ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

2009 • 493 citations

CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells

2008 • 492 citations

Coordination of Early Protective Immunity to Viral Infection by Regulatory T Cells

2008 • 452 citations

Specific immunity to listeria monocytogenes in the absence of IFNγ

1995 • 432 citations

Role of Th1 and Th17 cells in organ-specific autoimmunity

2008 • 419 citations

Antigen-driven effector CD8 T cell function regulated by T-bet

2003 • 413 citations

CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.

1994 • 397 citations

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

2009 • 394 citations

Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease

2007 • 388 citations

The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR7

2002 • 383 citations

Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response

2009 • 382 citations

Coordinate Expression and Trans Presentation of Interleukin (IL)-15Rα and IL-15 Supports Natural Killer Cell and Memory CD8+ T Cell Homeostasis

2004 • 364 citations

Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-β Are Resistant to Th17 Conversion by IL-6

2008 • 347 citations

Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors

2009 • 337 citations

Chemokines in the systemic organization of immunity

2003 • 335 citations

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

2009 • 324 citations

CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset

2004 • 314 citations

A Role for CD103 in the Retention of CD4+CD25+ Treg and Control of Leishmania major Infection

2005 • 313 citations

CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells

2007 • 311 citations

Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell–driven B cell responses

2004 • 282 citations

The Majority of Human Peripheral Blood CD4+CD25highFoxp3+ Regulatory T Cells Bear Functional Skin-Homing Receptors

2006 • 278 citations

Topically Applied 1,25-Dihydroxyvitamin D3 Enhances the Suppressive Activity of CD4+CD25+ Cells in the Draining Lymph Nodes

2007 • 267 citations

Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation

2007 • 262 citations

Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo

2005 • 250 citations

Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell–driven B cell responses

2004 • 241 citations

CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence

2006 • 224 citations

CD4⁺ T‐regulatory cells: toward therapy for human diseases

2008 • 221 citations

Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver

2010 • 218 citations

Human Th17 Cells Share Major Trafficking Receptors with Both Polarized Effector T Cells and FOXP3+ Regulatory T Cells

2008 • 218 citations

The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery

2007 • 217 citations

Cutting Edge: All-Trans Retinoic Acid Sustains the Stability and Function of Natural Regulatory T Cells in an Inflammatory Milieu

2010 • 212 citations

CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo

2007 • 210 citations

CXCR3 Signaling Reduces the Severity of Experimental Autoimmune Encephalomyelitis by Controlling the Parenchymal Distribution of Effector and Regulatory T Cells in the Central Nervous System

2007 • 192 citations

Antigen-specific peripheral shaping of the natural regulatory T cell population

2008 • 185 citations

IL-1β and IL-2 convert human Treg into TH17 cells

2009 • 174 citations

Epithelial Inflammation Is Associated with CCL28 Production and the Recruitment of Regulatory T Cells Expressing CCR10

2006 • 170 citations

Foxp3+ regulatory T cells maintain immune homeostasis in the skin

2008 • 170 citations

Foxp3+ T Cells Induce Perforin-Dependent Dendritic Cell Death in Tumor-Draining Lymph Nodes

2010 • 165 citations

Regulation of Trafficking Receptor Expression in Human Forkhead Box P3+ Regulatory T Cells

2006 • 161 citations

Induction of organ‐selective CD4⁺ regulatory T cell homing

2007 • 158 citations

IL-10 Controls Ultraviolet-Induced Carcinogenesis in Mice

2007 • 148 citations

Expansion of Antigen-Specific Regulatory T Cells with the Topical Vitamin D Analog Calcipotriol

2009 • 144 citations

Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells

2009 • 139 citations

CCR8 Expression Identifies CD4 Memory T Cells Enriched for FOXP3+ Regulatory and Th2 Effector Lymphocytes

2006 • 137 citations

CCR4-dependent regulatory T cell function in inflammatory bowel disease

2007 • 128 citations

Cutting Edge: CD4+CD25+ Regulatory T Cells Impaired for Intestinal Homing Can Prevent Colitis

2005 • 124 citations

FoxP3+ T Cells Undergo Conventional First Switch to Lymphoid Tissue Homing Receptors in Thymus but Accelerated Second Switch to Nonlymphoid Tissue Homing Receptors in Secondary Lymphoid Tissues

2007 • 123 citations

Tumor necrosis factor α blockade exacerbates murine psoriasis‐like disease by enhancing Th17 function and decreasing expansion of Treg cells

2010 • 121 citations

Clinical value of blocking IL-6 receptor

2009 • 111 citations

Cutting Edge: The Th1 Response Inhibits the Generation of Peripheral Regulatory T Cells

2009 • 109 citations

TNF-α: An Activator of CD4+FoxP3+TNFR2+ Regulatory T Cells

2010 • 106 citations

IL‐2Rβ links IL‐2R signaling with Foxp3 expression

2007 • 101 citations

Role of TCR specificity in CD4⁺CD25⁺ regulatory T‐cell selection

2006 • 95 citations

Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis

2009 • 93 citations

Therapy of autoinflammatory syndromes

2009 • 90 citations

Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice

2008 • 88 citations

Regulatory T cells in systemic lupus erythematosus: past, present and future

2008 • 86 citations

CD4+CXCR4highCD69+ T Cells Accumulate in Lung Adenocarcinoma

2006 • 83 citations

T Helper Differentiation Proceeds Through Stat1-Dependent, Stat4-Dependent and Stat4-Independent Phases

1999 • 81 citations

Constitutive Expression of IDO by Dendritic Cells of Mesenteric Lymph Nodes: Functional Involvement of the CTLA-4/B7 and CCL22/CCR4 Interactions

2009 • 69 citations

Vitamin A rewrites the ABCs of oral tolerance

2008 • 68 citations

Effects of interleukin 4 on CD25+CD4+ regulatory T cell function

2005 • 67 citations

Interferon‐alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responses

2010 • 67 citations

Effect of IFN-ß therapy on the frequency and function of CD4+CD25+ regulatory T cells and Foxp3 gene expression in relapsing–remitting multiple sclerosis (RRMS): A preliminary study

2009 • 63 citations

Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis

2007 • 62 citations

Identification of a Chemokine Network That Recruits FoxP3+ Regulatory T Cells Into Chronically Inflamed Intestine

2007 • 60 citations

CD25+CD4+ Regulatory T Cell Migration Requires L-Selectin Expression: L-Selectin Transcriptional Regulation Balances Constitutive Receptor Turnover

2007 • 56 citations

STAT6 Activation Confers upon T Helper Cells Resistance to Suppression by Regulatory T Cells

2009 • 55 citations

CD4+CD25+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype

2008 • 49 citations

Costimulatory effects of IL-1 on the expansion/differentiation of CD4+CD25+Foxp3+ and CD4+CD25+Foxp3– T cells

2008 • 30 citations

Skin Inflammation Arising from Cutaneous Regulatory T Cell Deficiency Leads to Impaired Viral Immune Responses

2010 • 29 citations