Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

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Enhancement of Antitumor Immunity by CTLA-4 Blockade

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N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

2008 • 2,656 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

CTLA-4: new insights into its biological function and use in tumor immunotherapy

2002 • 923 citations

Effector and Memory CTL Differentiation

2006 • 908 citations

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

2009 • 882 citations

CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells

2006 • 677 citations

HUMAN T CELL RESPONSES AGAINST MELANOMA

2005 • 638 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

2012 • 462 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+regulatory T cells

2005 • 451 citations

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product.

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Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3 ⁺ CD4 ⁺ regulatory T cells

2008 • 370 citations

NY‐ESO‐1: Review of an Immunogenic Tumor Antigen

2006 • 354 citations

CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit

2008 • 341 citations

The GITR–GITRL interaction: co-stimulation or contrasuppression of regulatory activity?

2006 • 276 citations

Perspectives of γδ T Cells in Tumor Immunology

2007 • 248 citations

CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion

2008 • 242 citations

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

2008 • 206 citations

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product

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In vivo antigen delivery by aSalmonella typhimurium type III secretion system for therapeutic cancer vaccines

2006 • 176 citations

A colon tumor model for anticancer agent evaluation

2006 • 129 citations

Immune recognition of self in immunity against cancer

2004 • 127 citations

IFN-γ Controls the Generation/Activation of CD4+CD25+ Regulatory T Cells in Antitumor Immune Response

2005 • 102 citations

Regulatory T Cell–Resistant CD8+ T Cells Induced by Glucocorticoid-Induced Tumor Necrosis Factor Receptor Signaling

2008 • 85 citations

Interleukin 12 Stimulates IFN-γ–Mediated Inhibition of Tumor-Induced Regulatory T-Cell Proliferation and Enhances Tumor Clearance

2009 • 77 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3[+]CD25[+]CD4[+] regulatory T cells

2006 • 70 citations

Role of SEREX-defined immunogenic wild-type cellular molecules in the development of tumor-specific immunity

2001 • 69 citations

Tumor progression inhibits the induction of multifunctionality in adoptively transferred tumor‐specific CD8⁺ T cells

2008 • 53 citations

Engagement of Glucocorticoid-Induced TNF Receptor Costimulates NKT Cell Activation In Vitro and In Vivo

2006 • 45 citations

Inhibition of murine γδ lymphocyte expansion and effector function by regulatory αβ T cells is cell‐contact‐dependent and sensitive to GITR modulation

2009 • 33 citations