Induction of T cell anergy: integration of environmental cues and infectious tolerance

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

2008 • 2,656 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

Ido expression by dendritic cells: tolerance and tryptophan catabolism

2004 • 2,235 citations

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

2007 • 1,890 citations

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

2007 • 1,816 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

T Cell Anergy

2003 • 1,418 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression

2007 • 1,181 citations

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

2009 • 1,172 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase

2005 • 1,156 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

2010 • 1,064 citations

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

2008 • 999 citations

The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells

2006 • 982 citations

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

2008 • 814 citations

Fuel feeds function: energy metabolism and the T-cell response

2005 • 813 citations

Infectious immunological tolerance.

1971 • 811 citations

Immunoregulatory functions of mTOR inhibition

2009 • 808 citations

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

2007 • 770 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

2007 • 695 citations

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2004 • 512 citations

Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells

2007 • 502 citations

A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells

2007 • 468 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

CD8+CD205+ Splenic Dendritic Cells Are Specialized to Induce Foxp3+ Regulatory T Cells

2008 • 412 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4+CD44hi Cells

2008 • 349 citations

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

2009 • 315 citations

Skin-draining lymph nodes contain dermis-derived CD103− dendritic cells that constitutively produce retinoic acid and induce Foxp3+ regulatory T cells

2010 • 306 citations

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

1999 • 288 citations

Metabolism in T cell activation and differentiation

2010 • 272 citations

A Role for Mammalian Target of Rapamycin in Regulating T Cell Activation versus Anergy

2007 • 268 citations

The ‘danger’ sensors that STOP the immune response: the A2 adenosine receptors?

2005 • 263 citations

Anergic T Cells Are Metabolically Anergic

2009 • 255 citations

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

2009 • 250 citations

T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-α

2006 • 250 citations

Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity

2010 • 239 citations

TRAF6 is a T cell–intrinsic negative regulator required for the maintenance of immune homeostasis

2006 • 200 citations

Dendritic cells are specialized accessory cells along with TGF-β for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3− precursors

2007 • 196 citations

T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response

2009 • 178 citations

CTLA-4 suppresses the pathogenicity of self antigen–specific T cells by cell-intrinsic and cell-extrinsic mechanisms

2009 • 169 citations

The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1

2008 • 166 citations

Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines

2009 • 150 citations

New Insights into the Molecular Basis of T Cell Anergy: Anergy Factors, Avoidance Sensors, and Epigenetic Imprinting

2009 • 150 citations

NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells

2005 • 142 citations

Cutting Edge: Deficiency in the E3 Ubiquitin Ligase Cbl-b Results in a Multifunctional Defect in T Cell TGF-β Sensitivity In Vitro and In Vivo

2006 • 138 citations

The E3 Ubiquitin Ligase GRAIL Regulates T Cell Tolerance and Regulatory T Cell Function by Mediating T Cell Receptor-CD3 Degradation

2010 • 134 citations

Resistance to CD4+CD25+ Regulatory T Cells and TGF-β in Cbl-b−/− Mice

2004 • 120 citations

De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR

2008 • 119 citations

Dendritic cells as controllers of antigen-specific Foxp3+ regulatory T cells

2009 • 119 citations

Tryptophan catabolism generates autoimmune-preventive regulatory T cells

2006 • 101 citations

GRAIL Is Up-regulated in CD4+ CD25+ T Regulatory Cells and Is Sufficient for Conversion of T Cells to a Regulatory Phenotype

2007 • 68 citations

ICER/CREM‐mediated transcriptional attenuation of IL‐2 and its role in suppression by regulatory T cells

2007 • 66 citations

Deltex1 Is a Target of the Transcription Factor NFAT that Promotes T Cell Anergy

2009 • 63 citations

IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes

2008 • 61 citations

The Novel Cyclophilin Binding Compound, Sanglifehrin A, Disassociates G1 Cell Cycle Arrest from Tolerance Induction

2004 • 47 citations

TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27Kip1

2001 • 46 citations

Naive CD4 T Cell Proliferation Is Controlled by Mammalian Target of Rapamycin Regulation of GRAIL Expression

2009 • 42 citations

Cutting Edge: Requirement for TRAF6 in the Induction of T Cell Anergy

2008 • 40 citations

The Gcn2 Kinase as a Cell Cycle Regulator

2007 • 34 citations

Adenosine and anergy

2007 • 25 citations