Cancer/testis antigens: an expanding family of targets for cancer immunotherapy

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Epigenetic Reprogramming in Mammalian Development

2001 • 2,978 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

1997 • 1,235 citations

Human neoplasms elicit multiple specific immune responses in the autologous host.

1995 • 1,097 citations

brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2SWI2

1992 • 951 citations

Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by geneMAGE-3 and presented by HLA-A1

1999 • 803 citations

Simultaneous Humoral and Cellular Immune Response against Cancer–Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2–binding Peptide Epitopes

1998 • 728 citations

A Survey of the Humoral Immune Response of Cancer Patients to a Panel of Human Tumor Antigens

1998 • 712 citations

A listing of human tumor antigens recognized by T cells

2001 • 708 citations

T cell defined tumor antigens

1997 • 641 citations

BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes

1995 • 598 citations

Structure, chromosomal localization, and expression of 12 genes of the MAGE family

1994 • 595 citations

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

1995 • 591 citations

DNA Methylation Is the Primary Silencing Mechanism for a Set of Germ Line- and Tumor-Specific Genes with a CpG-Rich Promoter

1999 • 589 citations

The ADAM gene family: surface proteins with adhesion and protease activity

2000 • 582 citations

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

1996 • 552 citations

Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma.

1995 • 467 citations

Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers

2000 • 435 citations

Monitoring CD8 T cell responses to NY-ESO-1: Correlation of humoral and cellular immune responses

2000 • 407 citations

A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes.

1992 • 397 citations

The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.

1991 • 368 citations

Immunohistochemical analysis of NY-ESO-1 antigen expression in normal and malignant human tissues

2001 • 351 citations

Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome

2000 • 320 citations

Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library

1998 • 307 citations

Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine.

1994 • 292 citations

NRAGE, A Novel MAGE Protein, Interacts with the p75 Neurotrophin Receptor and Facilitates Nerve Growth Factor–Dependent Apoptosis

2000 • 287 citations

Expression of MAGE genes in primary and metastatic cutaneous melanoma

1995 • 285 citations

Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens

1998 • 281 citations

LAGE-1, a new gene with tumor specificity

1998 • 268 citations

SSX: A multigene family with several members transcribed in normal testis and human cancer

1997 • 242 citations

Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2?-deoxycytidine treatment

2001 • 234 citations

Identification of Ny-Eso-1 Epitopes Presented by Human Histocompatibility Antigen (Hla)-Drb4*0101–0103 and Recognized by Cd4+T Lymphocytes of Patients with Ny-Eso-1–Expressing Melanoma

2000 • 232 citations

Humoral immune responses of cancer patients against “Cancer-Testis” antigen NY-ESO-1: Correlation with clinical events

1999 • 230 citations

A monoclonal cytolytic T-lymphocyte response observed in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by geneMAGE-3

2001 • 222 citations

Expression of MAGE-antigens in normal tissues and cancer

2000 • 212 citations

Serological analysis of Melan-A(MART-1), a melanocyte-specific protein homogeneously expressed in human melanomas.

1996 • 209 citations

Disruption of the mouse necdin gene results in early post-natal lethality

1999 • 207 citations

Genes encoding tumor-specific antigens are expressed in human myeloma cells

1999 • 201 citations

Transfection and expression of a gene coding for a human melanoma antigen recognized by autologous cytolytic T lymphocytes

1992 • 198 citations

Monophasic and biphasic synovial sarcomas abundantly express cancer/testis antigen ny-eso-1 but not mage-a1 or ct7

2001 • 197 citations

Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.

2001 • 181 citations

Expression ofSSX genes in human tumors

1998 • 181 citations

Characterization of the GAGE genes that are expressed in various human cancers and in normal testis.

1999 • 167 citations

Sequential 5-Aza-2’-deoxycytidine-Depsipeptide FR901228 Treatment Induces Apoptosis Preferentially in Cancer Cells and Facilitates Their Recognition by Cytolytic T Lymphocytes Specific for NY-ESO-1

2001 • 164 citations

Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines.

2000 • 153 citations

Identification of CD4+ T Cell Epitopes from NY-ESO-1 Presented by HLA-DR Molecules

2000 • 149 citations

Serological detection of cutaneous T-cell lymphoma-associated antigens

2001 • 148 citations

Physical and Functional Interactions of Neuronal Growth Suppressor Necdin with p53

1999 • 146 citations

Expression of mage genes in transitional‐cell carcinomas of the urinary bladder

1995 • 141 citations

Monoclonal antibody MA454 reveals a heterogeneous expression pattern of MAGE-1 antigen in formalin-fixed paraffin embedded lung tumours

2000 • 141 citations

Identification and intracellular location of MAGE-3 gene product.

1995 • 140 citations

Identification of cancer/testis genes by database mining and mRNA expression analysis

2002 • 140 citations

Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9

2000 • 137 citations

An acrosomal protein, sp32, in mammalian sperm is a binding protein specific for two proacrosins and an acrosin intermediate

1994 • 134 citations

Molecular Expression Analysis of Restrictive Receptor for Interleukin 13, a Brain Tumor-associated Cancer/Testis Antigen

2000 • 134 citations

TheSSXgene family: Characterization of 9 complete genes

2002 • 130 citations

Imprinting in Angelman and Prader-Willi syndromes

1998 • 127 citations

Expression of multiple cancer-testis antigen genes in gastrointestinal and breast carcinomas

2001 • 126 citations

Identification on a Human Sarcoma of Two New Genes with Tumor-specific Expression

2000 • 124 citations

CT10: A new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis

2000 • 124 citations

Ny-ESO-1 expression and immunogenicity associated with transitional cell carcinoma: correlation with tumor grade.

2001 • 123 citations

NY-ESO-1 encodes DRB1*0401-restricted epitopes recognized by melanoma-reactive CD4+ T cells.

2000 • 121 citations

Identification and Characterization of a Novel Cancer/Testis Antigen Gene CAGE

2002 • 117 citations

Expression of cancer testis genes in human brain tumors.

2000 • 116 citations

Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen

2001 • 109 citations

Strategy for monitoring T cell responses to NY-ESO-1 in patients with any HLA class I allele

2000 • 108 citations

Isolation and characterization of a MAGE gene family in the Xp21.3 region.

1995 • 106 citations

Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database.

1999 • 104 citations

Genomic cloning and localization of CTAG, a gene encoding an autoimmunogenic cancer-testis antigen NY-ESO-1 to human chromosome Xq28

1997 • 100 citations

A RING Finger Protein Praja1 Regulates Dlx5-dependent Transcription through Its Ubiquitin Ligase Activity for the Dlx/Msx-interacting MAGE/Necdin Family Protein, Dlxin-1

2002 • 99 citations

Involvement of two Ets binding sites in the transcriptional activation of the MAGE1 gene

1995 • 93 citations

PAGE-1 , an X chromosome-linked GAGE- like gene that is expressed in normal and neoplastic prostate, testis, and uterus

1998 • 91 citations

Identification of the MAGE-1 gene product by monoclonal and polyclonal antibodies.

1994 • 89 citations

Neurotrophin Receptor-interacting Mage Homologue Is an Inducible Inhibitor of Apoptosis Protein-interacting Protein That Augments Cell Death

2001 • 89 citations

Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes

2001 • 84 citations

XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma.

2000 • 81 citations

The XAGE family of cancer/testis‐associated genes: Alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma

2002 • 73 citations

CTp11, a novel member of the family of human cancer/testis antigens.

1999 • 69 citations

Spermatid-Specific Expression of the Novel X-Linked Gene Product SPAN-X Localized to the Nucleus of Human Spermatozoa1

2000 • 66 citations

NY-ESO-1 and CTp11 Expression May Correlate with Stage of Progression in Melanoma

2001 • 66 citations

Role of phospholipases during sperm acrosomal exocytosis

1998 • 55 citations

Immunoreactivity with the Anti-MAGE Antibody 57B in Malignant Melanoma: Frequency of Expression and Correlation with Prognostic Parameters

2000 • 44 citations

Expression of BAGE, GAGE, and MAGE genes in human gastric carcinoma.

1996 • 42 citations

Human fertilin β: Identification, characterization, and chromosomal mapping of an ADAM gene family member

1997 • 38 citations

Necdin acts as a transcriptional repressor that interacts with multiple guanosine clusters

2001 • 37 citations

Expression profiling of MMA‐1a and splice variant MMA‐1b: New cancer/testis antigens identified in human melanoma

2002 • 36 citations

Human fertilin β: Identification, characterization, and chromosomal mapping of an ADAM gene family member

1997 • 33 citations

TRAG-3, a novel cancer/testis antigen, is overexpressed in the majority of melanoma cell lines and malignant melanoma.

2001 • 33 citations

Induction of MAGE Genes in Lymphoid Cells by the Demethylating Agent 5‐Aza‐2′‐deoxycytidine

1996 • 30 citations

Long-Range Organization of Reiterated Sequences, Including the SSX1 cDNA, at the OATL1 Cluster in Xp11.23

1995 • 20 citations

Localization of the MAGE1 gene encoding a human melanoma antigen to chromosome Xq28

1994 • 17 citations