NY‐ESO‐1: Review of an Immunogenic Tumor Antigen

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Intraepithelial CD8⁺tumor-infiltrating lymphocytes and a high CD8⁺/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

2005 • 2,226 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Cancer/testis antigens, gametogenesis and cancer

2005 • 1,541 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

1997 • 1,235 citations

The DNA sequence of the human X chromosome

2005 • 1,118 citations

Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

1994 • 771 citations

Simultaneous Humoral and Cellular Immune Response against Cancer–Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2–binding Peptide Epitopes

1998 • 728 citations

A Survey of the Humoral Immune Response of Cancer Patients to a Panel of Human Tumor Antigens

1998 • 712 citations

The cancer/testis genes: review, standardization, and commentary.

2004 • 670 citations

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

1996 • 552 citations

Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands

2004 • 525 citations

Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans

2004 • 446 citations

Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers

2000 • 435 citations

The Human Tumor Antigen PRAME Is a Dominant Repressor of Retinoic Acid Receptor Signaling

2005 • 412 citations

Monitoring CD8 T cell responses to NY-ESO-1: Correlation of humoral and cellular immune responses

2000 • 407 citations

Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

2001 • 406 citations

Autoreactive T Cells in Healthy Individuals

2004 • 374 citations

Cancer-Testis Genes Are Coordinately Expressed and Are Markers of Poor Outcome in Non–Small Cell Lung Cancer

2005 • 354 citations

Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters

2004 • 352 citations

Immunohistochemical analysis of NY-ESO-1 antigen expression in normal and malignant human tissues

2001 • 351 citations

Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine.

1994 • 292 citations

Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens

1998 • 281 citations

LAGE-1, a new gene with tumor specificity

1998 • 268 citations

Structural and kinetic basis for heightened immunogenicity of T cell vaccines

2005 • 250 citations

NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancer.

2003 • 242 citations

Identification of Ny-Eso-1 Epitopes Presented by Human Histocompatibility Antigen (Hla)-Drb4*0101–0103 and Recognized by Cd4+T Lymphocytes of Patients with Ny-Eso-1–Expressing Melanoma

2000 • 232 citations

Humoral immune responses of cancer patients against “Cancer-Testis” antigen NY-ESO-1: Correlation with clinical events

1999 • 230 citations

A Breast and Melanoma-Shared Tumor Antigen: T Cell Responses to Antigenic Peptides Translated from Different Open Reading Frames

1998 • 208 citations

Survey of naturally occurring CD4 ⁺ T cell responses against NY-ESO-1 in cancer patients: Correlation with antibody responses

2003 • 201 citations

NY-ESO-1 is highly expressed in poor-prognosis multiple myeloma and induces spontaneous humoral and cellular immune responses

2005 • 199 citations

CD4⁺T cell recognition of MHC class II-restricted epitopes from NY-ESO-1 presented by a prevalent HLA DP4 allele: Association with NY-ESO-1 antibody production

2001 • 199 citations

Monophasic and biphasic synovial sarcomas abundantly express cancer/testis antigen ny-eso-1 but not mage-a1 or ct7

2001 • 197 citations

Naturally occurring human lymphocyte antigen-A2 restricted CD8+ T-cell response to the cancer testis antigen NY-ESO-1 in melanoma patients.

2000 • 192 citations

Identification of NY-ESO-1 Peptide Analogues Capable of Improved Stimulation of Tumor-Reactive CTL

2000 • 172 citations

CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients

2005 • 169 citations

Identification of CD4+ T Cell Epitopes from NY-ESO-1 Presented by HLA-DR Molecules

2000 • 149 citations

Spontaneous Tumor-Specific Humoral and Cellular Immune Responses to NY-ESO-1 in Hepatocellular Carcinoma

2004 • 142 citations

Expression of cancer/testis (CT) antigens MAGE-A1, MAGE-A3, MAGE-A4, CT-7, and NY-ESO-1 in malignant gammopathies is heterogeneous and correlates with site, stage and risk status of disease.

2003 • 133 citations

Expression of cancer/testis (CT) antigens in lung cancer

2003 • 131 citations

Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells

2005 • 131 citations

Combined use of oligonucleotide and tissue microarrays identifies cancer/testis antigens as biomarkers in lung carcinoma.

2002 • 128 citations

Expression of multiple cancer-testis antigen genes in gastrointestinal and breast carcinomas

2001 • 126 citations

Ny-ESO-1 expression and immunogenicity associated with transitional cell carcinoma: correlation with tumor grade.

2001 • 123 citations

The impact of imiquimod, a Toll-like receptor-7 ligand (TLR7L), on the immunogenicity of melanoma peptide vaccination with adjuvant Flt3 ligand.

2004 • 122 citations

NY-ESO-1 encodes DRB1*0401-restricted epitopes recognized by melanoma-reactive CD4+ T cells.

2000 • 121 citations

NY-ESO-1 119-143 is a promiscuous major histocompatibility complex class II T-helper epitope recognized by Th1- and Th2-type tumor-reactive CD4+ T cells.

2002 • 115 citations

Accelerated chemically induced tumor development mediated by CD4 ⁺ CD25 ⁺ regulatory T cells in wild-type hosts

2005 • 111 citations

Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen

2001 • 109 citations

Strategy for monitoring T cell responses to NY-ESO-1 in patients with any HLA class I allele

2000 • 108 citations

Cancer/testis tumour-associated antigens: immunohistochemical detection with monoclonal antibodies

2003 • 107 citations

Interleukin-2-induced, melanoma-specific T cells recognize camel, an unexpected translation product ofLAGE-1

1999 • 103 citations

NY-ESO-1 Expression and Immunogenicity in Malignant and Benign Breast Tumors

2004 • 99 citations

Immunodominance of Poxviral-Specific CTL in a Human Trial of Recombinant-Modified Vaccinia Ankara

2005 • 96 citations

Immunodominant CD4 ⁺ responses identified in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant

2004 • 92 citations

Expression Profile of Cancer-Testis Genes in 121 Human Colorectal Cancer Tissue and Adjacent Normal Tissue

2005 • 90 citations

Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations

2002 • 88 citations

The Cancer-Testis Gene, NY-ESO-1, Is Expressed in Normal Fetal and Adult Testes and in Spermatocytic Seminomas and Testicular Carcinoma In Situ

2002 • 86 citations

A member of the GAGE family of tumor antigens is an anti-apoptotic gene that confers resistance to Fas/CD95/APO-1, Interferon-gamma, taxol and gamma-irradiation.

2002 • 84 citations

CD8⁺T cell responses against a dominant cryptic HLA-A2 epitope after NY-ESO-1 peptide immunization of cancer patients

2002 • 83 citations

NY‐ESO‐1 protein expression and humoral immune responses in prostate cancer

2004 • 78 citations

NY-ESO-1 tumour associated antigen is a cytoplasmic protein detectable by specific monoclonal antibodies in cell lines and clinical specimens

2000 • 77 citations

Frequency of NY-ESO-1 and LAGE-1 expression in bladder cancer and evidence of a new NY-ESO-1 T-cell epitope in a patient with bladder cancer.

2003 • 75 citations

Functional Avidity of Tumor Antigen-Specific CTL Recognition Directly Correlates with the Stability of MHC/Peptide Multimer Binding to TCR

2002 • 74 citations

The frequent expression of cancer/testis antigens provides opportunities for immunotherapeutic targeting of sarcoma.

2004 • 73 citations

Expression of cancer/testis (CT) antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters

2004 • 71 citations

Comprehensive analysis of the frequency of recognition of melanoma-associated antigen (MAA) by CD8 melanoma infiltrating lymphocytes (TIL): implications for immunotherapy

2001 • 69 citations

One NY-ESO-1-Derived Epitope That Promiscuously Binds to Multiple HLA-DR and HLA-DP4 Molecules and Stimulates Autologous CD4+ T Cells from Patients with NY-ESO-1-Expressing Melanoma

2005 • 68 citations

NY-ESO-1 Expression and Immunogenicity in Esophageal Cancer

2004 • 67 citations

Simultaneous CD8+ T cell responses to multiple tumor antigen epitopes in a multipeptide melanoma vaccine.

2003 • 67 citations

NY-ESO-1 mRNA expression and immunogenicity in advanced prostate cancer.

2003 • 64 citations

NY‐ESO‐1/LAGE‐1 coexpression with MAGE‐A cancer/testis antigens: A tissue microarray study

2005 • 62 citations

Immunohistochemical and Molecular Analysis of Human Melanomas for Expression of the Human Cancer-Testis Antigens NY-ESO-1 and LAGE-1

2004 • 61 citations

Influence of CD4+CD25+ Regulatory T Cells on Low/High-Avidity CD4+ T Cells following Peptide Vaccination

2006 • 58 citations

Expression and significance of cancer testis antigens in primary mucosal melanoma of the head and neck

2004 • 57 citations

Distinct Structural TCR Repertoires in Naturally Occurring Versus Vaccine-Induced CD8+ T-Cell Responses to the Tumor-Specific Antigen NY-ESO-1

2005 • 57 citations

Cross-Presentation of HLA Class I Epitopes from Exogenous NY-ESO-1 Polypeptides by Nonprofessional APCs

2003 • 56 citations

The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells

2015 • 56 citations

A Member of the GAGE Family of Tumor Antigens is an Anti-Apoptotic Gene that Confers Resistance to Fas/CD95/APO-1, Interferon-g, Taxol and g-irradiation

2002 • 56 citations

Immunization of HLA-A*0201 and/or HLA-DPβ1*04 Patients with Metastatic Melanoma Using Epitopes from the NY-ESO-1 Antigen

2004 • 54 citations

CD4+ Th2 Cell Recognition of HLA-DR-Restricted Epitopes Derived from CAMEL: A Tumor Antigen Translated in an Alternative Open Reading Frame

2003 • 52 citations

Monitoring CD4+ T cell responses against viral and tumor antigens using T cells as novel target APC

2003 • 51 citations

Expression of cancer testis antigens in pancreatic carcinoma cell lines, pancreatic adenocarcinoma and chronic pancreatitis

2004 • 50 citations

NY-ESO-1 expression and its serum immunoreactivity in esophageal cancer

2004 • 43 citations

Cancer/testis antigen expression and autologous humoral immunity to NY-ESO-1 in gastric cancer.

2004 • 41 citations

Dominant B cell epitope from NY‐ESO‐1 recognized by sera from a wide spectrum of cancer patients: Implications as a potential biomarker

2004 • 39 citations

Recombinant NY‐ESO‐1 Cancer Antigen: Production and Purification under cGMP Conditions

2005 • 39 citations

The alternative open reading frame of LAGE-1 gives rise to multiple promiscuous HLA-DR-restricted epitopes recognized by T-helper 1-type tumor-reactive CD4+ T cells.

2003 • 38 citations

IFN-γ enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation

2004 • 36 citations

Characterization of antigen-specific CD8+ T lymphocyte responses in skin and peripheral blood following intradermal peptide vaccination.

2005 • 34 citations

Identification of an antigenic peptide derived from the cancer-testis antigen NY-ESO-1 binding to a broad range of HLA-DR subtypes

2004 • 32 citations

hMAGE-A1 overexpression reduces TNF-alpha cytotoxicity in ME-180 cells.

2002 • 30 citations

Identification of a naturally processed NY-ESO-1 peptide recognized by CD8+ T cells in the context of HLA-B51.

2002 • 30 citations

The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer

2004 • 29 citations

A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved

2002 • 29 citations

Th1/Th2 CD4+ T cell responses against NY-ESO-1 in HLA-DPB1*0401/0402 patients with epithelial ovarian cancer.

2004 • 29 citations

Identification of Multiple HLA-DR-Restricted Epitopes of the Tumor-Associated Antigen CAMEL by CD4+ Th1/Th2 Lymphocytes

2004 • 19 citations

[Expression of tumor-specific cancer/testis antigens in hepatocellular carcinoma].

2003 • 13 citations

[Correlation of NY-ESO-1 gene and protein expression to metastasis and clinicopathologic features of hepatocellular carcinoma].

2005 • 12 citations

HLA-DP4 expression and immunity to NY-ESO-1: correlation and characterization of cytotoxic CD4+ CD25- CD8- T cell clones.

2004 • 11 citations

Urine antibody against human cancer antigen NY-ESO-1.

2002 • 8 citations

[Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery].

2004 • 8 citations

[Expression of NY-ESO-1/LAGE-1 genes in hepatocellular carcinoma and autologous humoral responses induced thereby].

2004 • 4 citations