Fibrosis of the Lung and Other Tissues: New Concepts in Pathogenesis and Treatment

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

1998 • 2,047 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Negative regulation of transforming growth factor-β by the proteoglycan decorin

1990 • 1,490 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

1997 • 1,010 citations

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.

1988 • 962 citations

Reduction of atherosclerosis in mice by inhibition of CD40 signalling

1998 • 917 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

1999 • 800 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis

1997 • 737 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2–dominated inflammatory response

1999 • 601 citations

A Preliminary Study of Long-Term Treatment with Interferon Gamma-1b and Low-Dose Prednisolone in Patients with Idiopathic Pulmonary Fibrosis

1999 • 585 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

A new view of prostaglandin E regulation of the immune response

1991 • 535 citations

Regulation of interferon-γ production by IL-12 and IL-18

1998 • 526 citations

Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation.

1997 • 499 citations

Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4.

1992 • 498 citations

Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney

1996 • 485 citations

Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study.

1994 • 470 citations

Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 467 citations

Inflammatory and immunomodulatory roles of TGF-β

1989 • 450 citations

Costimulation of Fibroblast Collagen and Transforming Growth Factor β1 Gene Expression by Monocyte Chemoattractant Protein-1 via Specific Receptors

1996 • 427 citations

Expression of functional CD40 by vascular endothelial cells.

1995 • 414 citations

An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

1995 • 403 citations

Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice.

1993 • 402 citations

Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice

1999 • 400 citations

Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice

2000 • 353 citations

Alveolar macrophage-derived cytokines induce monocyte chemoattractant protein-1 expression from human pulmonary type II-like epithelial cells

1991 • 352 citations

TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study.

1996 • 326 citations

Lung Cytokine Production in Bleomycin-Induced Pulmonary Fibrosis

1992 • 321 citations

Molecular Mechanisms of Antifibrotic Effect of Interferon Gamma in Bleomycin-Mouse Model of Lung Fibrosis: Downregulation of TGF-β and Procollagen I and III Gene Expression

1995 • 306 citations

Gamma interferon is the lymphokine and beta interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation.

1985 • 278 citations

Dose-dependent induction of transforming growth factor β (TGF-β) in the lung tissue of fibrosis-prone mice after thoracic irradiation

2000 • 267 citations

Production of Interleukin 13 by Alveolar Macrophages from Normal and Fibrotic Lung

1998 • 266 citations

Transfer of Tumor Necrosis Factor-α to Rat Lung Induces Severe Pulmonary Inflammation and Patchy Interstitial Fibrogenesis with Induction of Transforming Growth Factor-β1 and Myofibroblasts

1998 • 263 citations

Expression of monocyte chemoattractant protein 1 mRNA in human idiopathic pulmonary fibrosis.

1992 • 249 citations

Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells

1989 • 247 citations

Lung Inflammation and Fibrosis

1998 • 220 citations

CD40 stimulation provides an IFN-gamma-independent and IL-4-dependent differentiation signal directly to human B cells for IgE production.

1991 • 219 citations

Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis

1999 • 218 citations

A type 2 (Th2-like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis (CFA)

1995 • 204 citations

Anti-CD40 Ligand Antibody Treatment of SNF1 Mice with Established Nephritis: Preservation of Kidney Function

1998 • 202 citations

Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters

1999 • 188 citations

Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis.

1994 • 188 citations

Airway responsiveness and bronchial-wall thickness in asthma with or without fixed airflow obstruction.

1995 • 188 citations

Transient Transgene Expression of Decorin in the Lung Reduces the Fibrotic Response to Bleomycin

2001 • 184 citations

Apoptosis during wound healing, fibrocontractive diseases and vascular wall injury

1997 • 178 citations

TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression.

1997 • 177 citations

Clinical significance of MCP‐1 levels in BALF and serum in patients with interstitial lung diseases

1999 • 176 citations

Cytokines and pulmonary fibrosis.

1993 • 172 citations

Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis.

1994 • 164 citations

TGF-β: A Critical Modulator of Immune Cell Function

1997 • 160 citations

CD40 Expression by human fibroblasts

1995 • 158 citations

Interleukin-4 and interferon-γ discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets

1996 • 156 citations

Interferon-γ inhibits experimental renal fibrosis

1999 • 144 citations

Local Production of Interleukin-4 During Radiation-induced Pneumonitis and Pulmonary Fibrosis in Rats: Macrophages as a Prominent Source of Interleukin-4

1997 • 141 citations

Increased CD40 Expression on Muscle Cells of Polymyositis and Dermatomyositis: Role of CD40-CD40 Ligand Interaction in IL-6, IL-8, IL-15, and Monocyte Chemoattractant Protein-1 Production

2000 • 140 citations

CD40 engagement up-regulates cyclooxygenase-2 expression and prostaglandin E2 production in human lung fibroblasts.

1998 • 137 citations

IL-12 attenuates bleomycin-induced pulmonary fibrosis

2001 • 135 citations

Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation.

1997 • 124 citations

Role of Interleukin-10 in the Lung Response to Silica in Mice

1998 • 123 citations

Immunoregulatory role of CD40 in human B cell differentiation.

1993 • 122 citations

In vivo levels and in vitro production of interferon-gamma in fibrosing interstitial lung diseases

1992 • 116 citations

Cutting Edge: CD40 Engagement Up-Regulates Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Human Lung Fibroblasts

1998 • 108 citations

Decorin Attenuates Gliotic Scar Formation in the Rat Cerebral Hemisphere

1999 • 105 citations

Interleukin‐4 stimulates collagen gene expression in human fibroblast monolayer cultures Potential role in fibrosis

1992 • 104 citations

Altered accessory cell function of alveolar macrophages: a possible mechanism for induction of Th2 secretory profile in idiopathic pulmonary fibrosis

1997 • 88 citations

Different cytokine profiles in cryptogenic fibrosing alveolitis and fibrosing alveolitis associated with systemic sclerosis A quantitative study of open lung biopsies

1999 • 87 citations

Blockade of CD40–CD40 Ligand Interactions Protects against Radiation-Induced Pulmonary Inflammation and Fibrosis

1998 • 84 citations

Polarized Type 1 Cytokine Profile in Bronchoalveolar Lavage T Cells of Patients with Hypersensitivity Pneumonitis

1999 • 83 citations

Th2 cells as effectors in postirradiation pulmonary damage preceding fibrosis in the rat

1999 • 82 citations

Immunohistochemical localization of transforming growth factor-beta 1 in rats with experimental silicosis, alveolar type II hyperplasia, and lung cancer.

1993 • 82 citations

IL-12 Modulates Expression of Hypersensitivity Pneumonitis

1998 • 79 citations

Treatment of systemic sclerosis with γ-interferon

1992 • 79 citations

Cytokine mRNA gene expression in active and nonactive pulmonary sarcoidosis

1997 • 78 citations

Increased Levels of Interleukin-18 in Patients with Pulmonary Sarcoidosis

2000 • 76 citations

A Role for T Helper 2 Cells in Mediating Skin Fibrosis in Tight-Skin Mice

1999 • 75 citations

The role of IL-5 in bleomycin-induced pulmonary fibrosis

1998 • 69 citations

Lung Fibrosis Induced by Silica Particles in NMRI Mice Is Associated with an Upregulation of the p40 Subunit of Interleukin-12 and Th-2 Manifestations

1999 • 68 citations

Lung interleukin-5 expression in murine bleomycin-induced pulmonary fibrosis.

1997 • 68 citations

Disruption of the CD40-CD40 ligand system prevents an oxygen-induced respiratory distress syndrome.

1998 • 66 citations

Increased Expression of IL-12 Receptor mRNA in Active Pulmonary Tuberculosis and Sarcoidosis

1999 • 66 citations

Mediators of hypersensitivity pneumonitis

2000 • 66 citations

Immunohistochemical localization of transforming growth factor beta isoforms in asbestos-related diseases.

1997 • 56 citations

Interferon- γ Production by Specific Lung Lymphocyte Phenotypes in Silicosis in Mice

2000 • 55 citations

Repair mechanisms in asthma

1996 • 53 citations

Interferon-gamma regulates collagen and fibronectin gene expression by transcriptional and post-transcriptional mechanisms

1997 • 51 citations

Ligation of CD40 induced tumor necrosis factor-alpha in rheumatoid arthritis: a novel mechanism of activation of synoviocytes.

1999 • 45 citations

Immunohistochemical identification and characterization of smooth muscle-like cells in idiopathic pulmonary fibrosis.

1995 • 41 citations

SELECTIVE INHIBITION OF COLLAGEN GENE EXPRESSION IN FIBROBLASTS BY AN INTERFERON-gamma TRANSGENE

1999 • 41 citations

The biology of the human ligand for CD40

1993 • 38 citations

Chemotactic Cytokines Mediate Leukocyte Recruitment in Fibrotic Lung Disease

1996 • 32 citations

The value of interleukin-12 as an activity marker of pulmonary sarcoidosis.

2000 • 24 citations

The Value of Interleukin-12 as an Activity Marker of Pulmonary Sarcoidosis

1999 • 13 citations

Transient Gene Transfer and Expression in the Lung

1997 • 9 citations

Evaluation of CD30 as a marker for Th2 lymphocytes in bronchoalveolar lavage in interstitial lung diseases

2000 • 9 citations

The model for almost all seasons?

1992 • 2 citations

Deleted Work

1955 • 0 citations