A Role for T Helper 2 Cells in Mediating Skin Fibrosis in Tight-Skin Mice

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

1995 • 1,120 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

1988 • 374 citations

Lymphocytes in the skin of patients with progressive systemic sclerosis

1984 • 369 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

T helper 1 and T helper 2 cells respond differentially to chemokines.

1998 • 309 citations

Interleukin‐1, Interleukin‐2, Interleukin‐4, Interleukin‐6, Tumor Necrosis Factor α, and Interferon‐γ Levels in Sera from Patients With Scleroderma

1992 • 303 citations

A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation.

1996 • 290 citations

A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein

1992 • 286 citations

Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton.

1976 • 279 citations

Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

1994 • 276 citations

Cutting Edge: T Helper 1 and T Helper 2 Cells Respond Differentially to Chemokines

1998 • 238 citations

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

1989 • 231 citations

Th2 Cells Are Required for theSchistosoma mansoniEgg-Induced Granulomatous Response

1998 • 227 citations

Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis.

1994 • 188 citations

The αβ T Cell Receptor Can Replace the γδ Receptor in the Development of γδ Lineage Cells

1996 • 161 citations

Interleukin-4 and interferon-γ discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets

1996 • 156 citations

Anti-IL-4 treatment prevents dermal collagen deposition in the tight-skin mouse model of scleroderma

1998 • 154 citations

Interleukin-4 stimulates collagen synthesis by normal and scleroderma fibroblasts in dermal equivalents.

1991 • 154 citations

Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo.

1997 • 123 citations

Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma

1995 • 117 citations

Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis.

1996 • 106 citations

Interleukin‐4 stimulates collagen gene expression in human fibroblast monolayer cultures Potential role in fibrosis

1992 • 104 citations

Expression of Interleukin-4 in Scleroderma Skin Specimens and Scleroderma Fibroblast Cultures

1996 • 98 citations

Lymphokine regulation of inflammatory processes: Interleukin-4 stimulates fibroblast proliferation

1988 • 98 citations

A role for CD4⁺ T cells in the pathogenesis of skin fibrosis in tight skin mice

1994 • 81 citations

CD2 Regulates the Positive Selection and Function of Antigen-Specific CD4−CD8+ T Cells

1997 • 80 citations

Induction of Skin Fibrosis and Autoantibodies by Infusion of Immunocompetent Cells from Tight Skin Mice into C57BL/6 Pa/Pa Mice

1993 • 74 citations

Interferon-gamma regulates collagen and fibronectin gene expression by transcriptional and post-transcriptional mechanisms

1997 • 51 citations

B-cell Deficiency does not Abrogate Development of Cutaneous Hyperplasia in Mice Inheriting the Defective Fibrillin-1 Gene

1997 • 50 citations

Expansion of selected V delta 1+ gamma delta T cells in systemic sclerosis patients.

1994 • 49 citations

Evidence for autoimmunity in the tight skin mouse model of systemic sclerosis

1991 • 41 citations

Anti‐interleukin‐4 treatment diminishes secretion of Th2 cytokines and inhibits hepatic fibrosis in murine schistosomiasis japonica

1995 • 36 citations

Adoptive Transfer of tsk Skin Fibrosis to +/+ Recipients by tsk Bone Marrow and Spleen Cells

1989 • 33 citations

Transforming growth factor-beta 1 and collagen gene expression during postnatal skin development and fibrosis in the tight-skin mouse.

1995 • 33 citations

The Tight Skin (Tsk) Mutation in the Mouse, a Model for Human Fibrotic Diseases, Is Tightly Linked to the β2-Microglobulin (B2m) Gene on Chromosome 2

1993 • 30 citations

Fibrogenic cytokines in vulvar lichen sclerosus. An immunohistochemical study.

1997 • 30 citations

Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin.

1995 • 20 citations

Animal Models of Fibrosis

1990 • 20 citations

T Cells Infiltrating the Skin ofTsk2Scleroderma-Like Mice Exhibit T Cell Receptor Bias

1998 • 19 citations

Interferon-gamma, an Anti-fibrogenic Cytokine which Binds to Heparan Sulfate

1994 • 17 citations

Fibrosin, a Novel Fibrogenic Protein: Discovery, Cloning and Implications for Fibrotic Disorders

1996 • 13 citations

Positive Selection of Thymocytes Expressing the Same TCR by Different MHC Ligands Results in the Production of Functionally Distinct Thymocytes Distinguished by Differential Expression of the Heat Stable Antigen

1998 • 11 citations