Interferon-gamma regulates collagen and fibronectin gene expression by transcriptional and post-transcriptional mechanisms

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct.

1979 • 975 citations

Modified procedure for the assay of H3- or C14-labeled hydroxyproline

1966 • 710 citations

Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts.

1984 • 579 citations

Cloning and characterization of five overlapping cDNAs specific for the human proα 1(I) collagen chain

1982 • 496 citations

TGF-β: Regulation of extracellular matrix

1992 • 485 citations

Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution.

1983 • 393 citations

Selective inhibition of human diploid fibroblast collagen synthesis by interferons.

1984 • 336 citations

Proteolytic enzymes as probes for the triple-helical conformation of procollagen

1981 • 334 citations

Extracellular matrix and the regulation of lung development and repair ¹

1992 • 195 citations

Transcriptional regulation of interferon‐stimulated genes

1991 • 184 citations

Isolation and characterization of cDNA clones for human and bovine fibronectins.

1983 • 184 citations

Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels.

1990 • 178 citations

Differential effects of gamma-interferon on collagen and fibronectin gene expression.

1987 • 156 citations

Synthesis and degradation of type I procollagen mRNAs in cultured human skin fibroblasts and the effect of cortisol.

1985 • 148 citations

Cell surface expression of class II histocompatibility antigens occurs in the absence of the invariant chain.

1986 • 142 citations

Structure of cDNA clones coding for the entire preproα1 (III) chain of human type III procollagen. Differences in protein structure from type I procollagen and conservation of codon preferences

1989 • 132 citations

Lung collagen: more than scaffolding.

1986 • 122 citations

Interferon-activated signal transduction to the nucleus

1994 • 108 citations

Effect of γ-Interferon on Collagen Synthesis by Normal and Fibrotic Human Lung Fibroblasts

1992 • 102 citations

Interferon-gamma downregulates CFTR gene expression in epithelial cells

1994 • 102 citations

Persistence of a reduced-collagen-producing phenotype in cultured scleroderma fibroblasts after short-term exposure to interferons.

1987 • 97 citations

Forskolin inducibility and tissue-specific expression of the fibronectin promoter.

1989 • 91 citations

Interferon‐γ reverses the stimulation of collagen but not fibronectin gene expression by transforming growth factor‐ β in normal human fibroblasts

1990 • 89 citations

Pentoxifylline, Pentifylline, and Interferons Decrease Type I and III Procollagen mRNA Levels in Dermal Fibroblasts: Evidence for Mediation by Nuclear Factor 1 Down-Regulation

1995 • 85 citations

Effects of interferon-gamma on expression of cell surface receptors for collagen and deposition of newly synthesized collagen by cultured human lung fibroblasts.

1989 • 81 citations

Regulation of human lung fibroblast alpha 1(I) procollagen gene expression by tumor necrosis factor alpha, interleukin-1 beta, and prostaglandin E2

1993 • 79 citations

Interferon‐γ reverses the stimulation of collagen but not fibronectin gene expression by transforming growth factor‐β in normal human fibroblasts

1990 • 71 citations

New perspectives on basic mechanisms in lung disease. 1. Lung injury, inflammatory mediators, and fibroblast activation in fibrosing alveolitis.

1992 • 68 citations

Transforming growth factor-β stimulation of lung fibroblast prostaglandin E2 production

1989 • 66 citations

Cell adhesion regulates pro-alpha 1(I) collagen mRNA stability and transcription in mouse fibroblasts

1991 • 66 citations

Interferon-gamma upregulates interleukin-8 gene expression in human monocytic cells by a posttranscriptional mechanism

1994 • 63 citations

Gamma-interferon inhibits extracellular matrix synthesis and remodeling in collagen lattice cultures of normal and scleroderma skin fibroblasts.

1992 • 62 citations

Cloning and analysis of the 5′ portion of the human type-III procollagen gene (COL3A1)

1989 • 56 citations

Down‐regulation of α3(VI) chain expression by γ‐interferon decreases synthesis and deposition of collagen type VI

1989 • 50 citations

Mechanism of interferon-γ down-regulation of the interleukin 4-induced CD23/FcϵRII expression in human B cells: Post-transcriptional modulation by interferon-γ

1993 • 24 citations

A fibroblast protein binds the 3′-untranslated region of pro-α1(I) collagen mRNA

1993 • 23 citations

Effects of Transforming Growth Factor-β on Collagen Synthesis by Fetal Rat Lung Epithelial Cells

1991 • 21 citations

Biochemical Characterization of Collagens and of a Non-Collagenous Protein Synthesized by Guinea Pig Lung Fibroblasts in Culture

1983 • 16 citations

One and two-level regulation patterns affecting NF-kappa B mRNA and nuclear NF-kappa B activity after treatment with TNF-alpha, IFN-gamma and IL-4.

1993 • 1 citations