Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES

2005 • 2,075 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

2006 • 1,197 citations

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

1997 • 1,010 citations

Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody indb/dbdiabetic mice

2000 • 907 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

Neutralization of TGF-β by Anti-TGF-β Antibody Attenuates Kidney Hypertrophy and the Enhanced Extracellular Matrix Gene Expression in STZ-Induced Diabetic Mice

1996 • 658 citations

Transforming growth factor β (TGFβ) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts

1987 • 579 citations

Idiopathic Nonspecific Interstitial Pneumonia: Prognostic Significance of Cellular and Fibrosing Patterns

2000 • 527 citations

Role of Epithelial Cells in Idiopathic Pulmonary Fibrosis: From Innocent Targets to Serial Killers

2006 • 492 citations

Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema

2003 • 480 citations

Expression of the β6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling

1995 • 470 citations

Imatinib mesylate blocks a non‐Smad TGF‐β pathway and reduces renal fibrogenesis in vivo

2005 • 452 citations

Gene Expression Profiles Distinguish Idiopathic Pulmonary Fibrosis from Hypersensitivity Pneumonitis

2005 • 439 citations

Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis

2000 • 415 citations

Valvular Myofibroblast Activation by Transforming Growth Factor-β

2004 • 381 citations

Smad3 Null Mice Develop Airspace Enlargement and Are Resistant to TGF-β-Mediated Pulmonary Fibrosis

2004 • 367 citations

TGF-β: from latent to active

1999 • 329 citations

TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study.

1996 • 326 citations

In vivo inhibition of rat stellate cell activation by soluble transforming growth factor β type II receptor: A potential new therapy for hepatic fibrosis

1999 • 325 citations

Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing.

1995 • 324 citations

Antibody to transforming growth factor-β ameliorates tubular apoptosis in unilateral ureteral obstruction

2000 • 322 citations

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.

1996 • 312 citations

TGF‐β Latency: Biological Significance and Mechanisms of Activation

1997 • 261 citations

Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

2007 • 257 citations

Progressive Transforming Growth Factor β1–induced Lung Fibrosis Is Blocked by an Orally Active ALK5 Kinase Inhibitor

2004 • 246 citations

Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues.

1993 • 240 citations

Immune dysregulation in TGF-beta 1-deficient mice.

1994 • 231 citations

Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-β1 and TGF-β3

1999 • 228 citations

Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep.

1994 • 213 citations

Transforming Growth Factor-β-Dependent and -Independent Pathways of Induction of Tubulointerstitial Fibrosis in β6−/− Mice

2003 • 209 citations

Voluntary running induces fiber type-specific angiogenesis in mouse skeletal muscle

2004 • 199 citations

Soluble Transforming Growth Factor-β Type II Receptor Inhibits Negative Remodeling, Fibroblast Transdifferentiation, and Intimal Lesion Formation But Not Endothelial Growth

1999 • 197 citations

A Distinctive Alveolar Macrophage Activation State Induced by Cigarette Smoking

2005 • 197 citations

Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters

1999 • 188 citations

αvβ6 Integrin Regulates Renal Fibrosis and Inflammation in Alport Mouse

2007 • 186 citations

The Role of Strain Variation in Murine Bleomycin-lnduced Pulmonary Fibrosis^1,2

1983 • 183 citations

Integrin α1β1 and Transforming Growth Factor-β1 Play Distinct Roles in Alport Glomerular Pathogenesis and Serve as Dual Targets for Metabolic Therapy

2000 • 174 citations

The integrin α_Vβ₆ binds and activates latent TGFβ3

2001 • 160 citations

Function-blocking Integrin αvβ6 Monoclonal Antibodies

2004 • 153 citations

Transforming Growth Factor-ॆ1 Potentiates Renal Tubular Epithelial Cell Death by a Mechanism Independent of Smad Signaling

2003 • 144 citations

Latency and activation in the control of TGF-β

1996 • 121 citations

Regulation of Endothelial Cell Growth, Architecture, and Matrix Synthesis by TGF-β

1989 • 116 citations

Myofibroblasts and hyalinized collagen as markers of skin disease in systemic sclerosis

2006 • 110 citations

Recombinant soluble transforming growth factor β type II receptor ameliorates radiation enteropathy in mice

2000 • 108 citations

Increased Expression of β6-Integrin in Skin Leads to Spontaneous Development of Chronic Wounds

2004 • 103 citations

Modulation of collagen gene expression by cytokines: Stimulatory effect of transforming growth factor-β1, with divergent effects of epidermal growth factor and tumor necrosis factor-α on collagen type I and collagen type IV

1997 • 75 citations

Effects of anti-TGF-β type II receptor antibody on experimental glomerulonephritis

2001 • 55 citations

Activation of a fibroblast-specific enhancer of the Pro?2(I) collagen gene in tight-skin mice

2001 • 45 citations

Analysis of Hornozygous TGFβ1 Null Mouse Embryos Demonstrates Defects in Yolk Sac. Vasculogenesis and Hematopoiesis

1995 • 44 citations

Activation of Proα2(I) Collagen Promoter during Hepatic Fibrogenesis in Transgenic Mice

1998 • 34 citations

ALK5 inhibition in renal disease

2003 • 29 citations

Angiotensin II antagonism fails to ameliorate bleomycin-induced pulmonary fibrosis in mice

2005 • 25 citations

Idiopathic Interstitial Pneumonia: A Clinicopathological Perspective

2006 • 10 citations