Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-β1 and TGF-β3

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins

1971 • 1,396 citations

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

1997 • 1,010 citations

Fibrogenic cytokines and connective tissue production

1994 • 425 citations

Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability.

1988 • 420 citations

Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice.

1993 • 402 citations

Dynamic state of collagen: pathways of collagen degradation in vivo and their possible role in regulation of collagen mass

1987 • 379 citations

Structural biochemistry and activation of matrix metalloproteases

1993 • 347 citations

Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms

1990 • 342 citations

Pathobiology of pulmonary fibrosis

1990 • 326 citations

Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts.

1997 • 309 citations

Nitric oxide, an autocrine regulator of wound fibroblast synthetic function.

1997 • 256 citations

Transforming growth factors-beta 1, -beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis.

1997 • 243 citations

Role of Transforming Growth Factor- in Tissue Injury and Repair

1997 • 237 citations

Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells

1993 • 230 citations

Altered expression of small proteoglycans, collagen, and transforming growth factor-beta 1 in developing bleomycin-induced pulmonary fibrosis in rats.

1993 • 227 citations

Extracellular matrix biology in the lung

1996 • 212 citations

Differential Effects of Transforming Growth Factor-β on the Expression of Collagenase-1 and Collagenase-3 in Human Fibroblasts

1998 • 192 citations

Cytokines and pulmonary fibrosis.

1993 • 172 citations

Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix.

1996 • 165 citations

Matrix metalloproteases and lung disease.

1994 • 151 citations

Transforming growth factor beta 1 gene expression in human airways.

1994 • 129 citations

Transforming growth factor-beta 3.

1995 • 111 citations

TGF-β3 Stimulates and Regulates Collagen Synthesis Through TGF-β1-Dependent and Independent Mechanisms

1997 • 106 citations

Differential effects of transforming growth factor-β1 on the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in young and old human fibroblasts

1996 • 101 citations

Transforming growth factor-beta (TGF-beta) in silicosis.

1996 • 99 citations

Biochemistry and turnover of lung interstitium.

1990 • 99 citations

Control of Collagen Deposition in Mammalian Lung

1995 • 97 citations

Diverse cellular TGF-beta 1 and TGF-beta 3 gene expression in normal human and murine lung

1996 • 94 citations

Endogenous TGF-β Activity Is Modified during Cellular Aging: Effects on Metalloproteinase and TIMP-1 Expression

1996 • 94 citations

Biochemistry and turnover of lung interstitium

1990 • 87 citations

Pathogenesis of lung fibrosis and potential new therapeutic strategies.

1995 • 80 citations

Growth Factor Effects on the Expression of Collagenase and TIMP‐1 in Periodontal Ligament Cells

1995 • 72 citations

Transforming Growth Factor Beta (TGF-β) and Dexamethasone have Direct Opposing Effects on Collagen Metabolism in Low Passage Human Dermal FibroblastsIn Vitro

1994 • 63 citations

Oncostatin M Differentially Regulates Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-3 Gene Expression in Human Synovial Lining Cells

1996 • 62 citations

MMP and TIMP Expression Pattern in Pleural Effusions of Different Origins

1997 • 58 citations

Does Aldosterone-lnduced Cardiac Fibrosis Involve Direct Effects on Cardiac Fibroblasts?

1996 • 46 citations

TGF-beta is a bidirectional modulator of cytokine receptor expression on murine bone marrow cells. Differential effects of TGF-beta 1 and TGF-beta 3.

1993 • 46 citations

Transforming Growth Factor-β Signal Transduction

1996 • 38 citations

Enhanced collagen synthesis in cultured skin fibroblasts from insulin-dependent diabetic patients with nephropathy.

1997 • 35 citations

Regulation of Type I Collagen Production by Insulin and Transforming Growth Factor-β in Human Lung Fibroblasts

1996 • 33 citations

Cell cultures from cryopreserved human lung tissue

1992 • 22 citations

[52] Collagen production by fibroblasts

1988 • 21 citations

TGF-beta isoforms differentially attenuate EGF mitogenicity and receptor activity in fetal lung mesenchymal cells

1997 • 13 citations

Effects of Transforming Growth Factor-βl and Phorbol Ester on PALI-1 and PA Genes in Human Lung Cells

1997 • 7 citations