Integrin α1β1 and Transforming Growth Factor-β1 Play Distinct Roles in Alport Glomerular Pathogenesis and Serve as Dual Targets for Metabolic Therapy

Transforming growth factor-beta in disease: the dark side of tissue repair.

1992 • 1,126 citations

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

1990 • 1,002 citations

Identification of Mutations in the COL4A5 Collagen Gene in Alport Syndrome

1990 • 847 citations

Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments.

1991 • 755 citations

Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis

1996 • 708 citations

The Laminin α Chains: Expression, Developmental Transitions, and Chromosomal Locations of α1-5, Identification of Heterotrimeric Laminins 8–11, and Cloning of a Novel α3 Isoform

1997 • 661 citations

Molecular heterogeneity of basal laminae: isoforms of laminin and collagen IV at the neuromuscular junction and elsewhere.

1990 • 588 citations

Identification of mutations in the α3(IV) and α4(IV) collagen genes in autosomal recessive Alport syndrome

1994 • 495 citations

Distribution and Function of Laminins in the Neuromuscular System of Developing, Adult, and Mutant Mice

1997 • 433 citations

Sustained expression of TGF-β1 underlies development of progressive kidney fibrosis

1994 • 413 citations

Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal laminae: sequence, distribution, association with laminins, and developmental switches.

1994 • 403 citations

Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome.

1996 • 374 citations

Renal basement membrane components

1999 • 347 citations

Distribution and isolation of four laminin variants; tissue restricted distribution of heterotrimers assembled from five different subunits.

1990 • 346 citations

Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): implications for Alport syndrome.

1996 • 310 citations

Isoform switching of type IV collagen is developmentally arrested in X-linked Alport syndrome leading to increased susceptibility of renal basement membranes to endoproteolysis.

1997 • 307 citations

Integrin α1β1 Mediates a Unique Collagen-dependent Proliferation Pathway In Vivo

1998 • 299 citations

The dermal-epidermal junction of human skin contains a novel laminin variant.

1992 • 268 citations

Deletion of Integrin α1 by Homologous Recombination Permits Normal Murine Development but Gives Rise to a Specific Deficit in Cell Adhesion

1996 • 263 citations

Glomerular Basement Membrane

1998 • 226 citations

Mutations in the type IV collagen α3 (COL4A3) gene in autosomal recessive Alport syndrome

1994 • 212 citations

Merosin and laminin in myogenesis; specific requirement for merosin in myotube stability and survival.

1996 • 205 citations

Inhibition of TGF-β1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis

1996 • 205 citations

Soluble Transforming Growth Factor-β Type II Receptor Inhibits Negative Remodeling, Fibroblast Transdifferentiation, and Intimal Lesion Formation But Not Endothelial Growth

1999 • 197 citations

The structural relationship between mesangial cells and basement membrane of the renal glomerulus

1987 • 184 citations

Autosomal recessive Alport syndrome: Immunohistochemical study of type IV collagen chain distribution

1995 • 173 citations

Regulation of podocyte structure during the development of nephrotic syndrome

1998 • 166 citations

Gene therapy by transforming growth factor-β receptor-IgG Fc chimera suppressed extracellular matrix accumulation in experimental glomerulonephritis

1999 • 132 citations

Role of the α1β1 integrin complex in collagen gel contraction in vitro by fibroblasts

1995 • 130 citations

Renal Expression of Fibrotic Matrix Proteins and of Transforming Growth Factor-β (TGF-β) Isoforms in TGF-β Transgenic Mice

1999 • 125 citations

Recombinant Soluble Human α₃β₁Integrin: Purification, Processing, Regulation, and Specific Binding to Laminin-5 and Invasin in a Mutually Exclusive Manner

1998 • 110 citations

The Laminin α2-Chain Short Arm Mediates Cell Adhesion through Both the α1β1 and α2β1 Integrins

1997 • 101 citations

Distribution of the α1 and α2 chains of collagen IV and of collagens V and VI in Alport syndrome

1992 • 101 citations

Selective immunoreactivities of kidney basement membranes to monoclonal antibodies against laminin: localization of the end of the long arm and the short arms to discrete microdomains.

1989 • 97 citations

The N‐terminal globular domain of the laminin α1 chain binds to α1β1 and α2β1 integrins and to the heparan sulfate‐containing domains of perlecan

1998 • 96 citations

Role for transforming growth factor-β1 in Alport renal disease progression

1999 • 89 citations

Alterations in the expression of the a 3 b 1 integrin in certain membrane domains of the glomerular epithelial cells (podocytes) in diabetes mellitus

1997 • 85 citations

Characterization of recombinant soluble human transforming growth factor-β receptor Type II (rhTGF-βsRII)

1995 • 76 citations

Ultrastructural and immunohistochemical findings in Alport's syndrome

1998 • 74 citations

Enhancement of Cell Adhesion and Spreading by a Cartilage-specific Noncollagenous Protein, Cartilage Matrix Protein (CMP/Matrilin-1), via Integrin α1β1

1999 • 73 citations

Insertional Mutation of the Collagen Genes Col4a3 and Col4a4 in a Mouse Model of Alport Syndrome

1999 • 73 citations

Evidence for separate networks of classical and novel basement membrane collagen. Characterization of alpha 3(IV)-alport antigen heterodimer.

1992 • 73 citations

Transforming Growth Factor-β (TGF-β) Stimulates the Expression of β1 Integrins and Adhesion by Rat Mesangial Cells

1996 • 73 citations

α1β1 Integrin-Mediated Collagen Matrix Remodeling by Rat Mesangial Cells Is Differentially Regulated by Transforming Growth Factor-β and Platelet-Derived Growth Factor-BB

1999 • 59 citations

Alport Syndrome � Clinical Phenotypes, Incidence, and Pathology1,2

2015 • 56 citations

Ontogenesis of glomerular basement membrane: structural and functional properties.

1991 • 54 citations

Alport's syndrome.

1997 • 49 citations

Distribution of Integrin Subunits in Normal Human Kidney

1994 • 41 citations

Fine Mapping and Narrowing of the Genetic Interval of the Spinal Muscular Atrophy Region by Linkage Studies

1993 • 38 citations

Mesangial Cell-Glomerular Basement Membrane Connections Counteract Glomerular Capillary and Mesangium Expansion

1990 • 35 citations

Effect of Matrix Glycation on Expression of Type IV Collagen, MMP-2, MMP-9 and TIMP-1 by Human

1996 • 35 citations

Mouse kalinin B1 (laminin beta 3 chain): cloning and tissue distribution.

1995 • 32 citations

Glomerular Extracellular Matrix Components and Integrins

1998 • 30 citations

Administration of AGEs in vivo induces genes implicated in diabetic glomerulosclerosis.

1995 • 30 citations

Mesangial Cells and Their Adhesive Properties

1999 • 27 citations

Analysis of the Interaction between Two TGF-?-binding Proteins and Three TGF-? Isoforms Using Surface Plasmon Resonance

1995 • 16 citations