Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice

1997 • 1,463 citations

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

2000 • 1,099 citations

Pathologic Changes in the Peripheral Airways of Young Cigarette Smokers

1974 • 959 citations

Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase– and cathepsin-dependent emphysema

2000 • 624 citations

Quantitative Methods in the Study of Pulmonary Pathology

1962 • 597 citations

Elastase secretion by stimulated macrophages. Characterization and regulation.

1975 • 522 citations

TGF-β is a critical mediator of acute lung injury

2001 • 476 citations

Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis

2000 • 415 citations

Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice

2000 • 407 citations

Interferon γ Induction of Pulmonary Emphysema in the Adult Murine Lung

2000 • 398 citations

Genetic Epidemiology of Severe, Early-onset Chronic Obstructive Pulmonary Disease

1998 • 388 citations

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.

1996 • 312 citations

Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3)

2001 • 243 citations

Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3)

2001 • 225 citations

Overexpression of tumor necrosis factor-α produces an increase in lung volumes and pulmonary hypertension

2001 • 221 citations

Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.

1992 • 197 citations

Transforming Growth Factor-β1 Inhibition of Macrophage Activation Is Mediated via Smad3

2000 • 167 citations

The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain.

1994 • 165 citations

FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo

2001 • 162 citations

Transforming Growth Factor-β1 Inhibits Cytokine-mediated Induction of Human Metalloelastase in Macrophages

2000 • 162 citations

Human Macrophage Metalloelastase. GENOMIC ORGANIZATION, CHROMOSOMAL LOCATION, GENE LINKAGE, AND TISSUE-SPECIFIC EXPRESSION

1995 • 156 citations

Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmonary adenocarcinomas in transgenic mice.

1992 • 120 citations

Conditional epidermal expression of TGFβ1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia

2001 • 93 citations

A Novel Method of Gene Transcript Profiling in Airway Biopsy Homogenates Reveals Increased Expression of a Na⁺-K⁺-Cl⁻ Cotransporter (NKCC1) in Asthmatic Subjects

2001 • 92 citations

Expression of the Human Integrin β 6 Subunit in Alveolar Type II Cells and Bronchiolar Epithelial Cells Reverses Lung Inflammation in β 6 Knockout Mice

1998 • 76 citations

Effects of β Subunit Cytoplasmic Domain Deletions on the Recruitment of the Integrin αvβ6 to Focal Contacts

1994 • 26 citations

A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts.

1995 • 15 citations

Deleted Work

1955 • 0 citations