Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep.

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions.

1985 • 1,065 citations

Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of asthma

1990 • 916 citations

Identification of Activated T Lymphocytes and Eosinophils in Bronchial Biopsies in Stable Atopic Asthma

1990 • 890 citations

Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: Comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness

1991 • 681 citations

Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules.

1991 • 675 citations

Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells [published erratum appears in Blood 1990 Dec 1;76(11):2420]

1990 • 540 citations

Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity

1991 • 472 citations

Endothelial Interleukin-8: A Novel Inhibitor of Leukocyte-Endothelial Interactions

1989 • 459 citations

Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium.

1980 • 434 citations

Toxicity of Eosinophil Cationic Proteins for Guinea Pig Tracheal EpitheliumIn Vitro

1989 • 421 citations

Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin.

1990 • 400 citations

Immediate and Late Inflammatory Responses to Ragweed Antigen Challenge of the Peripheral Airways in Allergic Asthmatics: Cellular, Mediator, and Permeability Changes

1991 • 382 citations

Eosinophils, bronchial hyperreactivity and late‐phase asthmatic reactions

1985 • 348 citations

Human eosinophil, but not neutrophil, adherence to IL-1-stimulated human umbilical vascular endothelial cells is alpha 4 beta 1 (very late antigen-4) dependent.

1991 • 295 citations

Bronchoalveolar Lavage of Allergic Asthmatic Patients following Allergen Bronchoprovocation

1986 • 284 citations

Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils.

1986 • 283 citations

Mechanisms of eosinophil adherence to cultured vascular endothelial cells. Eosinophils bind to the cytokine-induced ligand vascular cell adhesion molecule-1 via the very late activation antigen-4 integrin receptor.

1991 • 268 citations

Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1.

1993 • 266 citations

Endothelial leukocyte adhesion molecule-1 mediates antigen-induced acute airway inflammation and late-phase airway obstruction in monkeys.

1991 • 233 citations

Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1.

1991 • 233 citations

Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 epitopes

1991 • 231 citations

Adhesion to fibronectin prolongs eosinophil survival.

1993 • 226 citations

Activated T-lymphocytes and eosinophils in the bronchial mucosa in isocyanate-induced asthma

1992 • 224 citations

VLA‐3: A novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterization

1986 • 214 citations

Airway Hyperresponsiveness, Increased Intracellular Spaces of Bronchial Epithelium, and Increased Infiltration of Eosinophils and Lymphocytes in Bronchial Mucosa in Asthma

1992 • 211 citations

Indirect evidence of bronchial inflammation assessed by titration of inflammatory mediators in BAL fluid of patients with asthma

1991 • 208 citations

T Lymphocytes and Activated Eosinophils in Airway Mucosa in Fatal Asthma and Cystic Fibrosis

1992 • 175 citations

Altered Adhesion Molecule Expression and Endothelial Cell Activation Accompany the Recruitment of Human Granulocytes to the Lung after Segmental Antigen Challenge

1992 • 154 citations

Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions.

1990 • 152 citations

Lymphocyte adhesion through very late antigen 4: evidence for a novel binding site in the alternatively spliced domain of vascular cell adhesion molecule 1 and an additional alpha 4 integrin counter-receptor on stimulated endothelium.

1992 • 150 citations

Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing.

1992 • 145 citations

Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein.

1992 • 143 citations

A monoclonal antibody to VLA-4 alpha-chain (CDw49d) induces homotypic lymphocyte aggregation.

1990 • 142 citations

Effect of the oral leukotriene antagonist, ICI 204,219, on antigen-induced bronchoconstriction in subjects with asthma

1992 • 136 citations

Signaling by vascular cell adhesion molecule‐1 (VCAM‐1) through VLA‐4 promotes CD3‐dependent T cell proliferation

1991 • 131 citations

Leukotriene D receptor blockade inhibits the immediate and late bronchoconstrictor responses to inhaled antigen in patients with asthma

1992 • 129 citations

Specific leukotriene formation by purified human eosinophils and neutrophils

1984 • 113 citations

Late-phase Asthmatic Reaction to Inhaled Allergen Is Associated with Early Recruitment of Eosinophils in the Airways

1991 • 110 citations

Characterization of a late phase pulmonary response after antigen challenge in allergic sheep.

1983 • 92 citations

A Bradykinin Antagonist Modifies Allergen-induced Mediator Release and Late Bronchial Responses in Sheep

1991 • 84 citations

Expression and functional characterization of a soluble form of vascular cell adhesion molecule 1

1991 • 81 citations

Factors predisposing to exercise-induced late asthmatic responses

1985 • 70 citations

Leukocyte-Endothelial Cell Adhesion as an Active, Multi-Step Process: A Combinatorial Mechanism for Specificity and Diversity in Leukocyte Targeting

1992 • 66 citations

Epithelium-dependent contraction of airway smooth muscle caused by eosinophil MBP

1990 • 65 citations

Epithelial augmentation of trachealis contraction caused by major basic protein of eosinophils

1989 • 64 citations

Cellular Markers of Inflammation in the Airways of Allergic Sheep with and without Allergen-induced Late Responses

1988 • 61 citations

Cloning and expression of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion molecule.

1991 • 57 citations

A bradykinin-antagonist blocks antigen-induced airway hyperresponsiveness and inflammation in sheep

1990 • 56 citations

A PAF antagonist blocks antigen-induced airway hyperresponsiveness and inflammation in sheep

1989 • 27 citations

Alpha 4/180, a novel form of the integrin alpha 4 subunit.

1993 • 26 citations

Deposition of aerosol particles in a straight tube with an abrupt obstruction

1984 • 23 citations

Regulation of T cell proliferation by anti-CD49d and anti-CD29 monoclonal antibodies

1992 • 20 citations

Expression of leukocyte adhesion molecules inbronchial biopsies from asthmatic and normal subjects

1993 • 1 citations

Deleted Work

1955 • 0 citations