Molecular Chemotherapy for Breast Cancer

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

Acid pH in tumors and its potential for therapeutic exploitation.

1989 • 1,633 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

1997 • 1,059 citations

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

1988 • 1,042 citations

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

1986 • 962 citations

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.

1991 • 950 citations

Sequence-Specific DNA Binding by the c-Myc Protein

1990 • 893 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group.

1992 • 855 citations

Fluorouracil: biochemistry and pharmacology.

1988 • 825 citations

Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells

1997 • 694 citations

Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives

1991 • 611 citations

Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer.

1990 • 602 citations

Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.

1989 • 592 citations

Differential Reactivity of a Novel Monoclonal Antibody (DF3) with Human Malignant versus Benign Breast Tumors

1984 • 583 citations

Human prostate-specific antigen: structural and functional similarity with serine proteases.

1986 • 580 citations

Human gene therapy

1992 • 559 citations

Hypoxia and drug resistance

1994 • 555 citations

Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells.

1981 • 552 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system.

1992 • 511 citations

Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma.

1992 • 478 citations

Myc and Max proteins possess distinct transcriptional activities

1992 • 478 citations

HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma.

1992 • 466 citations

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max

1992 • 458 citations

HER-2/neu amplification predicts poor survival in node-positive breast cancer.

1990 • 456 citations

Functional Analysis of the Transforming Growth Factor βResponsive Elements in the WAF1/Cip1/p21 Promoter

1995 • 440 citations

Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.

1996 • 418 citations

In vivo electrically mediated protein and gene transfer in murine melanoma

1998 • 411 citations

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

1993 • 411 citations

Tumor hypoxia: its impact on cancer therapy

1987 • 410 citations

Analysis of Insulin-Like Growth Factor I Gene Expression in Malignancy: Evidence for a Paracrine Role in Human Breast Cancer

1989 • 403 citations

The Glucose-Regulated Proteins (GRP78 and GRP94): Functions, Gene Regulation, and Applications

1994 • 391 citations

Targeting gene expression to hypoxic tumor cells

1997 • 373 citations

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.

1987 • 360 citations

Multifactorial analysis of p53 alteration in human cancer: A review

1994 • 359 citations

c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes

1991 • 335 citations

Differential responsiveness of human breast cancer cell lines MCF-7 and T47D to growth factors and 17 beta-estradiol.

1988 • 330 citations

Insulin-like growth factor receptor expression and function in human breast cancer.

1990 • 321 citations

Spatial and temporal control of gene therapy using ionizing radiation

1995 • 316 citations

Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy.

1991 • 315 citations

Oxygen in Human Tumors: Correlations between Methods of Measurement and Response to Therapy: Summary of a Workshop Held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland

1993 • 298 citations

AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression

1997 • 285 citations

Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy.

1996 • 278 citations

Drug sensitivity ("suicide") genes for selective cancer chemotherapy.

1994 • 277 citations

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

1995 • 274 citations

Prognostic significance of her‐2/neu expression in breast cancer and its relationship to other prognostic factors

1991 • 262 citations

Insulin-like growth factor II mRNA expression in human breast cancer.

1988 • 245 citations

Regulation of p21WAF1/CIP1 expression by p53-independent pathways.

1996 • 240 citations

In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.

1993 • 233 citations

Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation.

1984 • 229 citations

Serum insulin-like growth factor-binding protein-2 (IGFBP-2) is increased and IGFBP-3 is decreased in patients with prostate cancer: correlation with serum prostate-specific antigen.

1993 • 227 citations

c-myc amplification is a better prognostic factor than HER2/neu amplification in primary breast cancer.

1992 • 212 citations

Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954

1995 • 210 citations

The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro.

1995 • 209 citations

Human Gene Therapy

1992 • 206 citations

Immunoreactive prostate-specific antigen levels in female and male breast tumors and its association with steroid hormone receptors and patient age

1994 • 196 citations

The Geranylgeranyltransferase-I Inhibitor GGTI-298 Arrests Human Tumor Cells in G0/G1 and Induces p21WAF1/CIP1/SDI1 in a p53-independent Manner

1997 • 193 citations

c-erbB-2 expression in benign and malignant breast disease

1988 • 190 citations

Preclinical studies and clinical correlation of the effect of alkylating dose.

1988 • 188 citations

Multihormonal Regulation of the Progesterone Receptor in MCF-7 Human Breast Cancer Cells: Interrelationships among Insulin/Insulin-Like Growth Factor-I, Serum, and Estrogen*

1990 • 187 citations

The neu-oncogene: signal transduction pathways, transformation mechanisms and evolving therapies.

1994 • 186 citations

Prostate-specific antigen is a new favorable prognostic indicator for women with breast cancer.

1995 • 173 citations

Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene

1995 • 171 citations

Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells.

1993 • 167 citations

Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression.

1990 • 162 citations

Glioma Cells Transduced with anEscherichia coliCD/HSV-1 TK Fusion Gene Exhibit Enhanced Metabolic Suicide and Radiosensitivity

1997 • 161 citations

Transcriptional Regulatory Sequences of Carcinoembryonic Antigen: Identification and Use with Cytosine Deaminase for Tumor-Specific Gene Therapy

1995 • 160 citations

Drug Resistance in Oncology

1997 • 160 citations

Tissue distribution of antileukoprotease and lysozyme in humans.

1989 • 157 citations

Expression of the secretory leukoprotease inhibitor gene in epithelial cells.

1991 • 153 citations

Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif which interacts with CTF/NF-I.

1991 • 151 citations

Detection of prostate-specific antigen immunoreactivity in breast tumors

1994 • 150 citations

Prognostic value of p21(WAF1) and p53 expression in breast carcinoma: an immunohistochemical study in 261 patients with long-term follow-up.

1996 • 150 citations

Egr-1 negatively regulates human tumor cell growth via the DNA-binding domain.

1995 • 145 citations

Tumor cell bystander killing in colonic carcinoma utilizing the Escherichia coli DeoD gene to generate toxic purines.

1994 • 145 citations

Gene therapy targeted by radiation preferentially radiosensitizes tumor cells.

1994 • 143 citations

Gene therapy for cancer using tumour-specific prodrug activation.

1994 • 136 citations

A novel transcription factor, OB2-1, is required for overexpression of the proto-oncogene c-erbB-2 in mammary tumour lines.

1993 • 133 citations

Quantitation of HER-2/neu and c-myc gene amplification in breast carcinoma using fluorescence in situ hybridization.

1997 • 133 citations

The choice of prodrugs for gene directed enzyme prodrug therapy of cancer.

1995 • 131 citations

Measuring Tumor Hypoxia.

1996 • 131 citations

Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase

1995 • 130 citations

Defining a role for c-Myc in breast tumorigenesis

1997 • 125 citations

Genetic alterations of c-myc, c-erbB-2, and c-Ha-ras protooncogenes and clinical associations in human breast carcinomas.

1989 • 125 citations

Prevalence of amplification of the oncogenes c-myc, HER2/neu, and int-2 in one thousand human breast tumours: Correlation with steroid receptors

1992 • 123 citations

Analysis of the tissue-specific promoter of the MUC1 gene

1993 • 123 citations

p21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis

1997 • 119 citations

Oncogene Protein Co-Expression Value of Ha-ras, c-myc, c-fos, and p53 as Prognostic Discriminants for Breast Carcinoma

1995 • 118 citations

Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo

1996 • 118 citations

c-erbB-2 amplification in node-negative human breast cancer.

1989 • 117 citations

Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer.

1998 • 117 citations

Studies on the rate-limiting enzyme component in the microsomal monooxygenase system. Incorporation of purified NADPH-cytochrome c reductase and cytochrome P-450 into rat liver microsomes.

1978 • 117 citations

Characterization of cis-acting elements regulating transcription of the human DF3 breast carcinoma-associated antigen (MUC1) gene.

1993 • 114 citations

Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo.

1994 • 113 citations

Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter.

1995 • 113 citations

Insertion and extension of acyclic, dideoxy, and ara nucleotides by herpesviridae, human alpha and human beta polymerases. A unique inhibition mechanism for 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate.

1988 • 111 citations

High-level expression in Escherichia coli of enzymatically active fusion proteins containing the domains of mammalian cytochromes P450 and NADPH-P450 reductase flavoprotein.

1992 • 110 citations

Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours

1995 • 108 citations

Overexpression of the c‐erbB‐2 protein in human breast tumor cell lines

1989 • 106 citations

Metabolic suicide genes in gene therapy

1994 • 104 citations

Molecular characterization of prostate-specific antigen messenger RNA expressed in breast tumors.

1994 • 101 citations

Resistance to chemotherapeutic antimetabolites: a function of salvage pathway involvement and cellular response to DNA damage

1997 • 100 citations

Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.

1996 • 96 citations

Clinical applications of carcinoembryonic antigen.

1988 • 95 citations

Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069

1997 • 92 citations

Gene transfer technologies for the gene therapy of cancer.

1994 • 85 citations

C-ERBB-2 oncogens protein inIn situ and invasive lobular breast neoplasia

1991 • 85 citations

p21(Waf1/Cipl) and p53 Protein Expression in Breast Cancer

1997 • 84 citations

In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation

1997 • 81 citations

Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene.

1997 • 78 citations

Enhancer sequences of the DF3 gene regulate expression of the herpes simplex virus thymidine kinase gene and confer sensitivity of human breast cancer cells to ganciclovir.

1994 • 72 citations

Expression of the cyclin‐dependent kinase inhibitors p16^INK4, p15^INK4B and p21Waf1/cip1 in human breast cancer

1995 • 71 citations

Strategy for achieving selective killing of carcinomas.

1994 • 71 citations

Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins

1989 • 70 citations

Activation of the Radiosensitive EGR-1 Promoter Induces Expression of the Herpes Simplex Virus Thymidine Kinase Gene and Sensitivity of Human Glioma Cells to Ganciclovir

1995 • 69 citations

Relationship between abnormal p53 protein and failure to express p21 protein in human breast carcinomas

1997 • 69 citations

HER-2/neu oncogene expression and proliferation in breast cancers.

1990 • 68 citations

Mustard Prodrugs for Activation by Escherichia coli Nitroreductase in Gene-Directed Enzyme Prodrug Therapy

1997 • 67 citations

Transcriptional Regulation of the Carcinoembryonic Antigen Gene

1995 • 66 citations

Substrate-dependent competition of different P 450 isoenzymes for limiting NADPH-cytochrome P 450 reductase

1995 • 66 citations

Tumor progression: Potential role of unstable genomic changes

1990 • 66 citations

TP53 andMYC gene alterations independently predict poor prognosis in breast cancer patients

1996 • 66 citations

Tissue specific promoters in targeting systemically delivered gene therapy.

1996 • 65 citations

Architectural Accommodation in the Complex of Four p53 DNA Binding Domain Peptides with the p21/waf1/cip1 DNA Response Element

1997 • 65 citations

Antiprogestin Inhibition of Cell Cycle Progression in T-47D Breast Cancer Cells Is Accompanied by Induction of the Cyclin-Dependent Kinase Inhibitor p21

1997 • 65 citations

Characterization of the human L-plastin gene promoter in normal and neoplastic cells.

1993 • 64 citations

Two GC Boxes (Sp1 Sites) Are Involved in Regulation of the Activity of the Epithelium-specific MUC1 Promoter

1996 • 60 citations

Expression of the c-erbB2 gene in the BT474 human mammary tumor cell line: measurement of c-erbB2 mRNA half-life.

1993 • 58 citations

The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy.

1996 • 58 citations

A biological role for Egr-1 in cell survival following ultra-violet irradiation.

1995 • 57 citations

Induction of glucose regulated proteins during growth of a murine tumor

1993 • 57 citations

Recent developments in the design of bioreductive drugs.

1996 • 56 citations

Transcription of carcinoembryonic antigen in normal colon and colon carcinoma. In situ hybridization study and implication for a new in vivo functional model.

1993 • 54 citations

Genetic radiotherapy overcomes tumor resistance to cytotoxic agents.

1995 • 53 citations

Characterization of monoclonal antibodies to carcinoembryonic antigen with increased tumor specificity.

1986 • 49 citations

Use of the stress-inducible grp78/BiP promoter in targeting high level gene expression in fibrosarcoma in vivo.

1995 • 48 citations

Gene-directed enzyme prodrug therapy (GDEPT): choice of prodrugs

1996 • 48 citations

Oxygen regulated gene expression: Erythropoietin as a model system

1997 • 46 citations

Oxygen regulated 80 kDa protein and glucose regulated 78 kDa protein are identical

1991 • 45 citations

Gene Transfer Using a Novel Fusion Protein, GAL4/Invasin

1997 • 45 citations

Mathematical modelling of oxygen supply and oxygenation in tumor tissues: Prognostic, therapeutic, and experimental implications

1988 • 44 citations

Meningitis caused by Streptococcus pneumoniae showing high level resistance to penicillin

1995 • 44 citations

Investigation of alternative prodrugs for use with E. coli nitroreductase in 'suicide gene' approaches to cancer therapy.

1996 • 43 citations

Prognostic value oferb-B2 andmyc amplification in breast cancer imprints

1995 • 43 citations

DNA vaccination for cancer treatment.

1995 • 42 citations

Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements.

1996 • 42 citations

Definition of the expression of the human carcinoembryonic antigen and non‐specific cross‐reacting antigen in human breast and lung carcinomas

1993 • 41 citations

Cloning of the Complete Gene for Carcinoembryonic Antigen: Analysis of Its Promoter Indicates a Region Conveying Cell Type-Specific Expression

1990 • 41 citations

Isolation of an X-ray-responsive element in the promoter region of tissue-type plasminogen activator: potential uses of X-ray-responsive elements for gene therapy.

1994 • 40 citations

Immunohistochemical c-erbB-2 protooncogene expression and nuclear DNA content in human mammary carcinoma in situ.

1992 • 39 citations

Absence of p21 expression is associated with abnormal p53 in human breast carcinomas

1997 • 37 citations

c-erbB-2 protein expression in node negative breast cancer

1990 • 37 citations

CEA and NCA in Benign and Malignant Breast Tumors

1984 • 36 citations

Regulation of a Hybrid Gene by Glucose and Temperature in Hamster Fibroblasts

1984 • 35 citations

Expression of c-myc proteins in breast cancer as related to established prognostic factors and survival.

1995 • 35 citations

p21WAF1/CIP1 response to genotoxic agents in wild-type TP53 expressing breast primary tumours

1997 • 35 citations

N-myc protein expression in human breast carcinoma: prognostic implications.

1995 • 34 citations

Prostate-specific antigen promoter driven gene therapy targeting DNA polymerase-alpha and topoisomerase II alpha in prostate cancer.

1996 • 34 citations

VDEPT: An enzyme/prodrug gene therapy approach for the treatment of metastatic colorectal cancer

1995 • 32 citations

Use of targeted cationic liposomes in enhanced DNA delivery to cancer cells.

1996 • 32 citations

Immediate X-Ray-Inducible Responses from Mammalian Cells

1994 • 30 citations

Partial regression, yet incomplete eradication of mammary tumors in transgenic mice by retrovirally mediated HSVtk transfer 'in vivo'.

1996 • 30 citations

Transactivation of the grp78 Promoter by Malfolded Proteins, Glycosylation Block, and Calcium Ionophore Is Mediated through a Proximal Region Containing a CCAAT Motif Which Interacts with CTF/NF-I

1991 • 28 citations

Carcinoembryonic antigen immunocytochemistry in primary breast cancer

1989 • 27 citations

Plateau-phase cultures: an experimental model for identifying drugs which are bioactivated within the microenvironment of solid tumours

1997 • 27 citations

Critical determination of the frequency of c-erbB-2 amplification in breast cancer

1994 • 27 citations

MDA468 growth inhibition by EGF is associated with the induction of the cyclin-dependent kinase inhibitor p21WAF1.

1997 • 27 citations

Inhibition of Tumor Growth by Direct Intratumoral Gene Transfer of Herpes Simplex Virus Thymidine Kinase Gene with DNA–Liposome Complexes

1996 • 25 citations

Transcriptional regulation of DF3 gene expression in human MCF‐7 breast carcinoma cells

1990 • 23 citations

Local regression of breast tumors following intramammary ganciclovir administration in double transgenic mice expressing neu oncogene and herpes simplex virus thymidine kinase.

1995 • 21 citations

Tumour hypoxia: challenges for cancer chemotherapy

1992 • 20 citations

Gene therapy strategies for carcinoma of the breast

1997 • 19 citations

Localization of cea messenger RNA byin situ hybridization in normal colonic mucosa and colorectal adenocarcinomas

1992 • 18 citations

p53 protein expression in breast carcinomas. Comparative study with the wild type p53 induced proteins mdm2 and p21/waf1.

1997 • 18 citations

The Role of Oxygen Tension Distribution on the Radiation Response of Human Breast Carcinoma

1994 • 17 citations

Arfificial P450/reductase fusion enzymes: What can we learn from their structures?

1995 • 15 citations

The interaction of taxol and vinblastine with radiation induction of p53 and p21 WAF1/CIP1.

1996 • 13 citations

Influence of c-myc on the Progression of Human Breast Cancer

1996 • 12 citations

Ionizing Radiation and Teniposide Increase p21^waf1/cip1 and Promote Rb Dephosphorylation but Fail to Suppress E2F Activity in MCF-7 Breast Tumor Cells

1997 • 12 citations

HER-2/neu, c-Myc and cyclin-A in human breast cancer

1996 • 4 citations

ANALYSIS OF C-MYC MESSENGER-RNA EXPRESSION IN PRIMARY BREAST CARCINOMAS WITH CLINICAL FOLLOW-UP

1995 • 3 citations

Immunohistologic c-myc protein in benign breast disease and cancer

1996 • 1 citations

ANALYSIS OF C-MYC AMPLIFICATION BY THE DIFFERENTIAL POLYMERASE CHAIN-REACTION (D-PCR), STUDY IN BREAST-CANCER

1994 • 1 citations

Deleted Work

1955 • 0 citations