Ionizing Radiation and Teniposide Increase p21^waf1/cip1 and Promote Rb Dephosphorylation but Fail to Suppress E2F Activity in MCF-7 Breast Tumor Cells

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle

1995 • 918 citations

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

1991 • 708 citations

Suppression of Tumorigenicity of Human Prostate Carcinoma Cells by Replacing a Mutated RB Gene

1990 • 606 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

1995 • 491 citations

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1995 • 459 citations

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

1992 • 449 citations

A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.

1996 • 251 citations

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.

1995 • 226 citations

Cleavage of retinoblastoma protein during apoptosis: an interleukin 1 beta-converting enzyme-like protease as candidate.

1996 • 204 citations

Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways.

1994 • 196 citations

Unrestricted cell cycling and cancer

1995 • 164 citations

Transcriptional regulation during the mammalian cell cycle

1995 • 152 citations

DP and E2F proteins: components of a heterodimeric transcription factor implicated in cell cycle control

1994 • 152 citations

Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein

1994 • 143 citations

The role of E2F in the mammalian cell cycle

1993 • 136 citations

Inhibition of E2F Activity by the Cyclin-Dependent Protein Kinase Inhibitor p21 in Cells Expressing or Lacking a Functional Retinoblastoma Protein

1996 • 136 citations

Inhibition of G₁ Cyclin-Dependent Kinase Activity during Growth Arrest of Human Breast Carcinoma Cells by Prostaglandin A₂

1996 • 113 citations

Camptothecin, teniposide, or 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells.

1991 • 109 citations

Functional analysis of pRb2/p130 interaction with cyclins.

1996 • 109 citations

Functional interactions within adenovirus E1A protein complexes.

1994 • 100 citations

G2 block induced by DNA crosslinking agents and its possible consequences

1988 • 96 citations

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

1995 • 96 citations

Normal p53 status and function despite the development of drug resistance in human breast cancer cells.

1995 • 72 citations

Effects of cell cycle, wild-type p53 and DNA damage on p21CIP1/Waf1 expression in human breast epithelial cells.

1995 • 63 citations

Differences in inhibition of chromosome separation and G2 arrest by DNA topoisomerase II inhibitors merbarone and VM-26.

1995 • 57 citations

Retinoblastoma-repression of E2F-dependent transcription depends on the ability of the retinoblastoma protein to interact with E2F and is abrogated by the adenovirus E1A oncoprotein

1992 • 56 citations

Mutant p53-induced immortalization of primary human mammary epithelial cells.

1996 • 55 citations

The Rb gene suppresses the growth of normal cells.

1993 • 44 citations

Influence of ionizing radiation on proliferation, c-myc expression and the induction of apoptotic cell death in two breast tumour cell lines differing in p53 status

1997 • 39 citations

Staurosporine-induced G1 arrest is associated with the induction and accumulation of cyclin-dependent kinase inhibitors.

1996 • 25 citations

Role of Retinoblastoma Gene Product in p53-Mediated DNA Damage Response

1994 • 23 citations

Activation of a retinoblastoma-protein-dependent pathway by sphingosine

1995 • 22 citations

The Rb Gene Suppresses the Growth of Normal Cells

1994 • 14 citations