Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

1987 • 3,809 citations

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

1993 • 1,097 citations

In VitroEvidence That Metabolic Cooperation Is Responsible for the Bystander Effect Observed with HSVtkRetroviral Gene Therapy

1993 • 425 citations

Purification and properties of an endothelial cell growth factor from human platelets.

1987 • 330 citations

High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

1992 • 317 citations

Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.

1993 • 243 citations

In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.

1993 • 233 citations

Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity

1992 • 209 citations

In vitro and in vivo targeting of gene expression to melanoma cells.

1993 • 190 citations

5-Fluorouracil incorporation into human breast carcinoma RNA correlates with cytotoxicity.

1981 • 187 citations

Purification and tissue distribution of human thymidine phosphorylase; high expression in lymphocytes, reticulocytes and tumors

1990 • 180 citations

Fluorinated pyrimidines. Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides

1974 • 172 citations

Hepatic gene therapy: adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes.

1993 • 169 citations

5-Fluoro-2′-Deoxyuridylate: Covalent Complex with Thymidylate Synthetase

1972 • 168 citations

Deoxyribosyl Transfer

1964 • 139 citations

Kinetic studies of thymidine phosphorylase from mouse liver

1985 • 131 citations

Stimulation of 5-fluorouracil metabolic activation by interferon-α in human colon carcinoma cells

1992 • 127 citations

5-Fluorouracil incorporation in DNA of human breast carcinoma cells.

1982 • 117 citations

Synergism and Lack of Cross-resistance Between Short-term and Continuous Exposure to Fluorouracil in Human Colon Adenocarcinoma Cells

1993 • 82 citations

Identification and Comparative Analysis of Thymidine Phosphorylase in the Plasma of Healthy Subjects and Cancer Patients: Brief Communication 2

1977 • 81 citations

Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines.

1993 • 80 citations

Pentosyl Transfer Mechanisms of the Mammalian Nucleoside Phosphorylases

1968 • 71 citations

Sensitivity of human KB cells expressing platelet-derived endothelial cell growth factor to pyrimidine antimetabolites.

1993 • 71 citations

Locus of the interaction among 5-fluorouracil, leucovorin, and interferon-alpha 2a in colon carcinoma cells.

1993 • 70 citations

Potentiation of the antitumor activity of 5-fluorouracil in colon carcinoma cells by the combination of interferon and deoxyribonucleosides results from complementary effects on thymidine phosphorylase.

1994 • 54 citations

High-yield purification of platelet-derived endothelial cell growth factor: structural characterization and establishment of a specific antiserum

1989 • 53 citations

Anticachectic activity of 5'-deoxy-5-fluorouridine in a murine tumor cachexia model, colon 26 adenocarcinoma.

1990 • 53 citations

[59] Thymidine phosphorylase from Escherichia coli

1978 • 47 citations

In Vivo Potentiation of 5-Fluorouracil Cytotoxicity Against AKR Leukemia by Purines, Pyrimidines, and Their Nucleosides and Deoxynucleosides<xref ref-type="fn" rid="FN1">2</xref>

1980 • 32 citations

Elevated Thymidine Phosphorylase Activity in the Plasma and Ascitic Fluids of Tumor-Bearing Animals

1978 • 28 citations

The role of blood platelets in nucleoside metabolism: regulation of platelet thymidine phosphorylase

1988 • 15 citations

The degradation of 5′-deoxy-5-fluorouridine by pyrimidine nucleoside phosphorylase in normal and cancer tissues

1985 • 14 citations

Antitumor activity of a new fluoropyrimidine derivative, 5'-deoxy-5-fluorouridine, against murine and human experimental tumors.

1985 • 10 citations

Thymidine inhibits the incorporation of 5-fluoro-2′-deoxyuridine to DNA of mouse mammary tumour

1992 • 3 citations