Telomere Length, Telomerase Activity, and Replicative Potential in HIV Infection: Analysis of CD4+ and CD8+T Cells from HIV-discordant Monozygotic Twins

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

1994 • 1,133 citations

Telomerase activity in normal and malignant hematopoietic cells.

1995 • 748 citations

Genetic determination of telomere size in humans: a twin study of three age groups.

1994 • 738 citations

Qualitative Analysis of Immune Function in Patients with the Acquired Immunodeficiency Syndrome

1985 • 737 citations

Telomere Shortening Is Associated with Cell Division in Vitro and in Vivo

1995 • 528 citations

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis

1996 • 452 citations

Human naive and memory T lymphocytes differ in telomeric length and replicative potential.

1995 • 424 citations

Regulated expression of telomerase activity in human T lymphocyte development and activation.

1996 • 416 citations

Evidence for a Critical Telomere Length in Senescent Human Fibroblasts

1995 • 391 citations

Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts.

1996 • 378 citations

New Concepts in the Immunopathogenesis of HIV Infection

1995 • 323 citations

AIDS Pathogenesis: A Finite Immune Response to Blame?

1996 • 43 citations

Cell cycling in HIV infection: analysis ofin vivoactivated lymphocytes

1995 • 41 citations