Telomere lengthening and telomerase activation during human B cell differentiation

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Structure and function of telomeres

1991 • 3,524 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

A theory of marginotomy

1973 • 1,770 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

Germinal Centers

1994 • 1,680 citations

Origin of Concatemeric T7DNA

1972 • 1,591 citations

Current protocols in immunology

1992 • 1,464 citations

Telomerase activity in human germline and embryonic tissues and cells

1996 • 1,345 citations

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

1994 • 1,133 citations

Activation of telomerase in human lymphocytes and hematopoietic progenitor cells.

1995 • 871 citations

Telomeres: Beginning to Understand the End

1995 • 855 citations

Structure and variability of human chromosome ends.

1990 • 833 citations

Telomerase activity in normal and malignant hematopoietic cells.

1995 • 748 citations

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

1993 • 743 citations

Genetic determination of telomere size in humans: a twin study of three age groups.

1994 • 738 citations

TLC1 : Template RNA Component of Saccharomyces cerevisiae Telomerase

1994 • 727 citations

A Human Telomeric Protein

1995 • 689 citations

Analysis of somatic mutation in five B cell subsets of human tonsil.

1994 • 667 citations

Telomere length and replicative aging in human vascular tissues.

1995 • 630 citations

Sugar and Disease

1972 • 532 citations

TELOMERASES

1992 • 531 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

Mechanism and Regulation of Immunoglobulin Isotype Switching

1993 • 516 citations

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes.

1996 • 494 citations

Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity

1995 • 490 citations

Human naive and memory T lymphocytes differ in telomeric length and replicative potential.

1995 • 424 citations

Regulated expression of telomerase activity in human T lymphocyte development and activation.

1996 • 416 citations

B cell differentiation and isotype switching is related to division cycle number.

1996 • 393 citations

Differential Expression of Telomerase Activity in Hematopoietic Progenitors from Adult Human Bone Marrow

1996 • 390 citations

Telomerase Activity in Hematopoietic Cells Is Associated with Self-Renewal Potential

1996 • 385 citations

Regulation of Telomerase Activity in Immortal Cell Lines

1996 • 360 citations

Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by Rapid Up-Regulation of B7-1 and B7-2

1995 • 358 citations

Runaway telomere elongation caused by telomerase RNA gene mutations

1995 • 338 citations

Life and Death in Germinal Centers (Redux)

1996 • 315 citations

Activation of telomerase in a human tumor.

1994 • 289 citations

Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

1993 • 283 citations

Detection of Telomerase Activity in Malignant and Nonmalignant Skin Conditions

1996 • 274 citations

Telomerase activity in normal human epithelial cells.

1996 • 248 citations

Somatic hypermutation

1995 • 248 citations

Variability at the Telomeres of the Human X/Y Pseudoautosomal Region

1986 • 229 citations

Structure and Variability of Human Chromosome Ends

1990 • 229 citations

Telomerase regulation during entry into the cell cycle in normal human T cells.

1996 • 206 citations

Memory B and T Cells

1991 • 183 citations

The germinal center: a crucible for lymphocyte selection

1996 • 166 citations

Telomerase activation in normal B lymphocytes and non-Hodgkin's lymphomas

1996 • 154 citations

Bcl-2+ tonsillar plasma cells are rescued from apoptosis by bone marrow fibroblasts.

1996 • 142 citations

Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones?

1988 • 135 citations

Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines.

1996 • 127 citations

Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis.

1996 • 117 citations

Regulation of telomerase RNA template expression in human T lymphocyte development and activation.

1997 • 112 citations

Aging and cancer: are telomeres and telomerase the connection?

1995 • 109 citations

Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development

1996 • 108 citations

Cellular Aging and Cell Death

1996 • 93 citations

Expansion, Selection and Mutation of Antigen‐Specific B Cells in Germinal Centers

1992 • 83 citations

Telomerase Activity Is Induced by the Stimulation to Antigen Receptor in Human Peripheral Lymphocytes

1996 • 83 citations

Down-regulation of Telomerase Activity Is an Early Event in the Differentiation of HL60 Cells

1996 • 81 citations

DNA sequences complementary to human 7 SK RNA show structural similarities to the short mobile elements of the mammalian genome

1984 • 38 citations