Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

The Mathematical Theory of Optimal Processes

1965 • 4,415 citations

The Mathematical Theory of Optimal Processes.

1963 • 4,275 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Intraclonal generation of antibody mutants in germinal centres

1991 • 1,083 citations

Maturation of the immune response in germinal centers

1991 • 904 citations

Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigens

1991 • 743 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

1991 • 683 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Variability in the Lambda Light Chain Sequences of Mouse Antibody

1970 • 554 citations

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1984 • 534 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.

1992 • 456 citations

Germinal centres in T-cell-dependent antibody responses

1992 • 442 citations

The Dynamic Nature of the Antibody Repertoire

1988 • 321 citations

Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin.

1985 • 319 citations

The Role of Somatic Hypermutation in the Generation of Antibody Diversity

1989 • 305 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses

1987 • 230 citations

Timing, Genetic Requirements and Functional Consequences of Somatic Hypermutation during B‐Cell Development

1987 • 218 citations

Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes?

1989 • 94 citations

Expansion, Selection and Mutation of Antigen‐Specific B Cells in Germinal Centers

1992 • 83 citations

Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten.

1989 • 77 citations

Mutation and selection during the secondary response to 2-phenyloxazolone.

1991 • 68 citations

The efficiency of antibody affinity maturation: can the rate of B-cell division be limiting?

1990 • 54 citations

The molecular evolution of the immune response: idiotope‐specific suppression indicates that B cells express germ‐line‐encoded V genes prior to antigenic stimulation

1986 • 53 citations

Immunologic memory to phosphocholine keyhole limpet hemocyanin. Recurrent mutations in the lambda 1 light chain increase affinity for antigen.

1992 • 24 citations