Proteasomes and proteasome inhibition in the central nervous system

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Aggresomes: A Cellular Response to Misfolded Proteins

1998 • 2,116 citations

The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis

1999 • 1,872 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Glutamine Repeats and Neurodegeneration

2000 • 1,309 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Degradation of oxidized proteins in mammalian cells

1997 • 845 citations

Impaired Proteasome Function in Alzheimer's Disease

2000 • 795 citations

Proteasomal function is impaired in substantia nigra in Parkinson's disease

2001 • 631 citations

The 26S Proteasome Is Required for Estrogen Receptor-α and Coactivator Turnover and for Efficient Estrogen Receptor-α Transactivation

2000 • 561 citations

The Proteasome, a Novel Protease Regulated by Multiple Mechanisms

1999 • 540 citations

Prediction of the Coding Sequences of Unidentified Human Genes. II. The Coding Sequences of 40 New Genes (KIAA0041-KIAA0080) Deduced by Analysis of cDNA Clones from Human Cell Line KG-1

1994 • 500 citations

Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins

1995 • 492 citations

The Ubiquitin-related BAG-1 Provides a Link between the Molecular Chaperones Hsc70/Hsp70 and the Proteasome

2000 • 478 citations

p53-dependent Induction of Apoptosis by Proteasome Inhibitors

1997 • 473 citations

Roles of Nuclear Factor κB in Neuronal Survival and Plasticity

2000 • 465 citations

Comparative resistance of the 20S and 26S proteasome to oxidative stress

1998 • 442 citations

RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit

2001 • 438 citations

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

1995 • 438 citations

Ubiquitin, cellular inclusions and their role in neurodegeneration

1998 • 396 citations

Proteasomes: multicatalytic proteinase complexes

1993 • 395 citations

Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation

2000 • 383 citations

Hybrid Proteasomes

2000 • 342 citations

p34^Cdc28-Mediated Control of Cln3 Cyclin Degradation

1995 • 293 citations

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

2000 • 288 citations

Inhibition of the multicatalytic proteinase (proteasome) by 4‐hydroxy‐2‐nonenal cross‐linked protein

1997 • 264 citations

Possible involvement of proteasome inhibition in aging: implications for oxidative stress

2000 • 264 citations

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

1996 • 262 citations

Peroxynitrite Increases the Degradation of Aconitase and Other Cellular Proteins by Proteasome

1998 • 254 citations

ATP-dependent proteases that also chaperone protein biogenesis

1997 • 240 citations

Proteasome Inhibitors Induce Cytochrome c–Caspase-3-Like Protease-Mediated Apoptosis in Cultured Cortical Neurons

2000 • 230 citations

The neuroprotective potential of heat shock protein 70 (HSP70)

1999 • 230 citations

Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones

1999 • 228 citations

Nerve Growth Factor-Dependent Activation of NF-κB Contributes to Survival of Sympathetic Neurons

1998 • 225 citations

Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex.

1994 • 220 citations

Defective ubiquitination of cerebral proteins in Alzheimer's disease

2000 • 216 citations

Immunocytochemical Co-localization of the Proteasome in Ubiquitinated Structures in Neurodegenerative Diseases and the Elderly

1997 • 214 citations

Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway.

1995 • 213 citations

Increase of Oxidatively Modified Protein Is Associated With a Decrease of Proteasome Activity and Content in Aging Epidermal Cells

2000 • 205 citations

The 19S Regulatory Complex of the Proteasome Functions Independently of Proteolysis in Nucleotide Excision Repair

1999 • 203 citations

Primary structures of two homologous subunits of PA28, a γ‐interferon‐inducible protein activator of the 20S proteasome

1995 • 196 citations

Fibroblast cultures from healthy centenarians have an active proteasome

2000 • 192 citations

cDNA Cloning and Interferon γ Down-Regulation of Proteasomal Aubunits X and Y

1994 • 181 citations

Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins

2001 • 178 citations

Age-related alterations of proteasome structure and function in aging epidermis

2000 • 177 citations

Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family

1992 • 171 citations

Molecular chaperone function of mammalian Hsp70 and Hsp40-a review

2000 • 170 citations

New human gene encoding a positive modulator of HIV Tat-mediated transactivation

1992 • 163 citations

Proteasomes: Structure and Biology

1998 • 158 citations

Roles of molecular chaperones in the nervous system

2000 • 154 citations

Protein Aggregation and Pathogenesis of Huntingtons Disease: Mechanisms and Correlations

2000 • 148 citations

The stress gene response in brain.

1996 • 143 citations

4-Hydroxynonenal-modified amyloid-β peptide inhibits the proteasome: possible importance in Alzheimer’s disease*

2000 • 140 citations

New insights into the mechanisms and importance of the proteasome in intracellular protein degradation.

1997 • 140 citations

Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis.

2000 • 138 citations

Oxidative Stress-Associated Impairment of Proteasome Activity during Ischemia–Reperfusion Injury

2000 • 138 citations

Proteasome Involvement in Agonist-induced Down-regulation of μ and δ Opioid Receptors

2001 • 135 citations

cDNA Cloning, Expression, and Functional Characterization of PI31, a Proline-rich Inhibitor of the Proteasome

2000 • 132 citations

Protection from oxidative inactivation of the 20S proteasome byheat-shock protein 90

1998 • 128 citations

Activation of the Cell Death Program by Nitric Oxide Involves Inhibition of the Proteasome

1999 • 127 citations

Tissue Distribution of Constitutive Proteasomes, Immunoproteasomes, and PA28 in Rats

2000 • 126 citations

Age-related changes in the 20S and 26S proteasome activities in the liver of male F344 rats

1998 • 125 citations

Proteasome Involvement and Accumulation of Ubiquitinated Proteins in Cerebellar Granule Neurons Undergoing Apoptosis

2000 • 123 citations

The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes.

1993 • 121 citations

Reversible Effects of Long-Term Caloric Restriction on Protein Oxidative Damage

2000 • 120 citations

Possible role of NF-κB and p53 in the glutamate-induced pro-apoptotic neuronal pathway

1999 • 109 citations

Regulation of the heat shock conjugate Hsc70 in the mammalian cell: the characterization of the anti-apoptotic protein BAG-1 provides novel insights.

1998 • 106 citations

Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae.

1995 • 94 citations

Dopamine induces proteasome inhibition in neural PC12 cell line

2000 • 94 citations

The proteasome: a protein‐destroying machine

1998 • 93 citations

Molecular Cloning and Expression of a Pituitary Gland Protein Modulating Intestinal Fluid Secretion

1995 • 93 citations

The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes

1999 • 93 citations

Proteasome Inhibitor‐Induced Apoptosis of Glioma Cells Involves the Processing of Multiple Caspases and Cytochrome c Release

2000 • 93 citations

Prediction of the Coding Sequences of Unidentified Human Genes. III. The Coding Sequences of 40 New Genes (KIAA0081-KIAA0120) Deduced by Analysis of cDNA Clones from Human Cell Line KG-1

1995 • 89 citations

Persistent activation of cAMP-dependent protein kinase by regulated proteolysis suggests a neuron-specific function of the ubiquitin system in Aplysia

1995 • 88 citations

Immunohistochemical distribution and electron microscopic subcellular localization of the proteasome in the rat CNS.

1996 • 88 citations

Lactacystin, a specific inhibitor of the proteasome, induces apoptosis and activates caspase-3 in cultured cerebellar granule cells

2000 • 86 citations

cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome

1998 • 83 citations

Proteasome inhibitors induce mitochondria‐independent apoptosis in human glioma cells

1999 • 82 citations

Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes)

1991 • 81 citations

Regulated protein degradation in mitochondria

1996 • 79 citations

Immunohistochemical Distribution and Electron Microscopic Subcellular Localization of the Proteasome in the Rat CNS

1996 • 78 citations

Down-regulation of types I, II and III inositol 1,4,5-trisphosphate receptors is mediated by the ubiquitin/proteasome pathway

1999 • 77 citations

A physical map and candidate genes in the BRCA1 region on chromosome 17q12–21

1994 • 76 citations

Biochemical analysis of proteasomes from mouse microglia: Induction of immunoproteasomes by interferon-? and lipopolysaccharide

2000 • 74 citations

A Distinct ER/IC γ-Secretase Competes with the Proteasome for Cleavage of APP

1999 • 73 citations

Molecular Cloning and Expression of a 26 S Protease Subunit Enriched in Dileucine Repeats

1995 • 67 citations

Polyglutamine Expansions

2000 • 65 citations

Central nervous system DNA fragmentation induced by the inhibition of nuclear factor kappa B

1998 • 65 citations

Proteolysis of oxidised proteins and cellular senescence

2000 • 64 citations

Dietary Self-Selection Can Compensate an Age-Related Decrease of Rat Liver 20 S Proteasome Activity Observed With Standard Diet

1998 • 64 citations

Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signalling pathway

1999 • 63 citations

cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p

1995 • 60 citations

Stress and molecular chaperones in disease

2000 • 59 citations

Parkin is metabolized by the ubiquitin/proteosome system

2000 • 56 citations

The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous

1991 • 56 citations

cDNA Cloning and Functional Analysis of the p97 Subunit of the 26S Proteasome, a Polypeptide Identical to the Type‐1 Tumor‐Necrosis‐Factor‐Receptor‐Associated Protein‐2/55.11

1996 • 56 citations

Interferon‐γ up‐regulates a unique set of proteins in human keratinocytes

1993 • 55 citations

Microsequences of 145 proteins recorded in the two‐dimensional gel protein database of normal human epidermal keratinocytes

1992 • 54 citations

CDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p.

1996 • 54 citations

Involvement of the Ubiquitin-Proteasome Pathway in the Degradation of Nontyrosine Kinase-Type Cytokine Receptors of IL-9, IL-2, and Erythropoietin

2000 • 53 citations

Activation of the Multicatalytic Endopeptidase by Oxidants. Effects on Enzyme Structure

1996 • 53 citations

Proteasome inhibition results in increased poly-ADP-ribosylation: Implications for neuron death

2000 • 53 citations

Multicatalytic proteinase is present in Lewy bodies and neurofibrillary tangles in diffuse Lewy body disease brains

1991 • 51 citations

cDNA Cloning and Characterization of a Human Proteasomal Modulator Subunit, p27 (PSMD9)

1998 • 50 citations

Kinetic mechanism of activation by cardiolipin (diphosphatidylglycerol) of the rat liver multicatalytic proteinase

1993 • 50 citations

Purification and characterization of the antisecretory factor: a protein in the central nervous system and in the gut which inhibits intestinal hypersecretion induced by cholera toxin

1986 • 49 citations

Dual Roles of Proteasome in the Metabolism of Presenilin 1

1999 • 49 citations

Proteasome Contributes to the α‐Secretase Pathway of Amyloid Precursor Protein in Human Cells

1997 • 47 citations

Major Histocompatibility-encoded Human Proteasome LMP2

1995 • 44 citations

The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing

1993 • 40 citations

Prevention of β‐Amyloid Neurotoxicity by Blockade of the Ubiquitin—Proteasome Proteolytic Pathway

2000 • 40 citations

The prosomal RNA-binding protein p27K is a member of the α-type human prosomal gene family

1993 • 38 citations

Synthetic peptide-based activators of the proteasome.

1997 • 37 citations

Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues

1994 • 34 citations

Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIα expression☆

2001 • 32 citations

cDNA Cloning of p40, a Regulatory Subunit of the Human 26S Proteasome, and a Homolog of the Mov-34 Gene Product

1995 • 28 citations

cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome

1997 • 27 citations

cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family

1996 • 27 citations

Two mRNAs exist for the Hs PROS-30 gene encoding a component of human prosomes

1992 • 26 citations

Constitutive and interferon-γ-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 11EMBL accession number for MECL1 cDNA: Y13640.1

1998 • 26 citations

Biochemical Purification of Distinct Proteasome Subsets

1993 • 20 citations

Cytosolic Components Are Required for Proteasomal Degradation of Newly Synthesized Apolipoprotein B in Permeabilized HepG2 Cells

1999 • 17 citations

Multicatalytic proteinase is associated with characteristic oval structures in cortical Lewy bodies: an immunocytochemical study with light and electron microscopy

1994 • 16 citations

Cytokine Induced Changes in Proteasome Subunit Composition Are Concentration Dependent

1996 • 16 citations

Molecular cloning and expression of subunit 9 of the 26S proteasome

1997 • 15 citations

Down-regulation of types I, II and III inositol 1,4,5-trisphosphate receptors is mediated by the ubiquitin/proteasome pathway

1999 • 14 citations

Cytoplasmic Presenilin Aggregates in Proteasome Inhibitor‐treated Cells

2000 • 9 citations

Modulation of the PA28α–20S Proteasome Interaction by a Peptidyl Alcohol

1999 • 6 citations