Reversible Effects of Long-Term Caloric Restriction on Protein Oxidative Damage

Tissue sulfhydryl groups

1959 • 25,130 citations

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

[37] Carbonyl assays for determination of oxidatively modified proteins

1994 • 2,605 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

1994 • 1,461 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence

1982 • 757 citations

Caloric Intake and Aging

1997 • 736 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Oxidative damage during aging targets mitochondrial aconitase

1997 • 612 citations

Nutritional Influences on Aging of Fischer 344 Rats: I. Physical, Metabolic, and Longevity Characteristics

1985 • 587 citations

Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.

1996 • 493 citations

Aging and oxidative stress: Modulation by dietary restriction

1996 • 450 citations

Mitochondrial adenine nucleotide translocase is modified oxidatively during aging

1998 • 408 citations

Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice

1994 • 346 citations

Effect of Age and Caloric Intake on Protein Oxidation in Different Brain Regions and on Behavioral Functions of the Mouse

1996 • 290 citations

Biomarkers of aging

1988 • 286 citations

Mitochondrial oxidative damage, hydrogen peroxide release, and aging

1994 • 273 citations

Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria

1998 • 253 citations

Biology of Aging: Observations and Principles

1998 • 220 citations

Longevity, Body Weight, and Neoplasia in Ad Libitum-Fed and Diet-Restricted C57BL6 Mice Fed NIH-31 Open Formula Diet

1995 • 188 citations

Biological Effects of Dietary Restriction

1991 • 144 citations

Modification of age-related immune decline in mice dietarily restricted from or after midadulthood.

1982 • 128 citations

Aging and Proteolysis of Oxidized Proteins

1994 • 116 citations

Toward the behavioral assessment of biological aging in the laboratory mouse: Concepts, terminology, and objectives

1983 • 107 citations

Possible Mechanisms Underlying the Antiaging Actions of Caloric Restriction

1996 • 88 citations

Effect of Chronic Caloric Restriction on the Circadian Regulation of Physiological and Behavioral Variables in Old Male B₆C₃F₁Mice

1990 • 81 citations

Effect of the Spin-Trapping CompoundN-tert-Butyl-α-phenylnitrone on Protein Oxidation and Life Span

1995 • 55 citations

Biomarkers of age and aging

1997 • 54 citations

Estimating age-related changes in psychomotor function: influence of practice and of level of caloric intake in different genotypes☆

1999 • 44 citations

Role of Caloric Restriction in the Prolongation of Life

1995 • 35 citations

Assessing Interviewer Effects in a Longitudinal Study of Bereaved Elderly Adults

1985 • 31 citations

Effect of Chronic Caloric Restriction on the Circadian Regulation of Physiological and Behavioral Variables in Old Male B6C3F1 Mice

1990 • 19 citations