cDNA Cloning and Interferon γ Down-Regulation of Proteasomal Aubunits X and Y

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

Proteolysis, proteasomes and antigen presentation

1992 • 576 citations

MHC-linked LMP gene products specifically alter peptidase activities of the proteasome

1993 • 453 citations

A molecular model of MHC class-I-restricted antigen processing

1992 • 438 citations

A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC

1991 • 427 citations

Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival.

1991 • 421 citations

Interferon-γ Induces Different Subunit Organizations and Functional Diversity of Proteasomes1

1994 • 371 citations

Second proteasome-related gene in the human MHC class II region

1991 • 348 citations

A role for the ubiquitin-dependent proteolytic pathway in MHC class l-restricted antigen presentation

1993 • 317 citations

Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes.

1994 • 314 citations

PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins.

1993 • 260 citations

Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene

1991 • 256 citations

Primary structure of the Thermoplasma proteasome and its implications for the structure, function, and evolution of the multicatalytic proteinase

1992 • 235 citations

A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis

1993 • 211 citations

Calculation of the isoelectric points of polypeptides from the amino acid composition

1986 • 185 citations

Proteasomes are regulated by interferon gamma: implications for antigen processing.

1992 • 177 citations

The PRE4 gene codes for a subunit of the yeast proteasome necessary for peptidylglutamyl-peptide-hydrolyzing activity. Mutations link the proteasome to stress- and ubiquitin-dependent proteolysis.

1993 • 149 citations

Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon‐γ for acquirement of the functional diversity responsible for antigen processing

1994 • 121 citations

Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits.

1992 • 119 citations

Proteasomes: protein and gene structures.

1992 • 108 citations

A tight cluster of five unrelated human genes on chromosome 16q22.1

1993 • 83 citations

Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes)

1991 • 81 citations

PRE3, highly homologous to the human major histocompatibility complex‐linked LMP2 (RING12) gene, codes for a yeast proteasome subunit necessary for the peptidylglutamyl‐peptide hydrolyzing activity

1994 • 80 citations

The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous

1991 • 56 citations

MHC-linked low-molecular mass polypeptide subunits define distinct subsets of proteasomes. Implications for divergent function among distinct proteasome subsets.

1993 • 53 citations

The prosomal RNA-binding protein p27K is a member of the α-type human prosomal gene family

1993 • 38 citations

Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues

1994 • 34 citations

Identification and localization of a cysteinyl residue critical for the trypsin-like catalytic activity of the proteasome

1992 • 32 citations

cDNA cloning of rat proteasome subunit RC10‐II, assumed to be responsible for trypsin‐like catalytic activity

1993 • 16 citations