Decreased levels of proteasome activity and proteasome expression in aging spinal cord

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

The ubiquitin-proteasome pathway: on protein death and cell life

1998 • 1,401 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Reactive Oxygen-Mediated Protein Oxidation in Aging and Disease

1998 • 891 citations

Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction

1998 • 874 citations

Degradation of oxidized proteins in mammalian cells

1997 • 845 citations

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

1997 • 727 citations

Neuroblastoma × spinal cord (NSC) hybrid cell lines resemble developing motor neurons

1992 • 681 citations

Glutamate-induced neuron death requires mitochondrial calcium uptake

1998 • 623 citations

Activation of the cell death program by inhibition of proteasome function

1997 • 494 citations

p53-dependent Induction of Apoptosis by Proteasome Inhibitors

1997 • 473 citations

Protein modification by the lipid peroxidation product 4‐hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

1998 • 382 citations

Protein Oxidative Damage in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

1998 • 287 citations

Inhibition of the multicatalytic proteinase (proteasome) by 4‐hydroxy‐2‐nonenal cross‐linked protein

1997 • 264 citations

4‐Hydroxynonenal, a Lipid Peroxidation Product, Rapidly Accumulates Following Traumatic Spinal Cord Injury and Inhibits Glutamate Uptake

1997 • 191 citations

A New Inhibitor of the Chymotrypsin‐Like Activity of the Multicatalytic Proteinase Complex (20S Proteasome) Induces Accumulation of Ubiquitin‐Protein Conjugates in a Neuronal Cell

1994 • 183 citations

Relationship of oxygen radical-induced lipid peroxidative damage to disease onset and progression in a transgenic model of familial ALS

1998 • 180 citations

Nuclear factor-κB/Rel proteins

1999 • 180 citations

Intracellular distribution of proteasomes

1998 • 161 citations

Protein Oxidation in Aging Braina

1992 • 123 citations

The effects of aging on spinal neurochemistry in the rat

1997 • 115 citations

Serum concentration and localization in tumor cells of proteasomes in patients with hematologic malignancy and their pathophysiologic significance.

1993 • 111 citations

The Lipid Peroxidation Product 4-Hydroxynonenal Impairs Glutamate and Glucose Transport and Choline Acetyltransferase Activity in NSC-19 Motor Neuron Cells

1999 • 107 citations

The proteasome: a protein‐destroying machine

1998 • 93 citations

Immunohistochemical distribution and electron microscopic subcellular localization of the proteasome in the rat CNS.

1996 • 88 citations

Age-related changes in human spinal ventral horn cells with special reference to the loss of small neurons in the intermediate zone: a quantitative analysis

1996 • 85 citations

Proteasome inhibitors induce mitochondria‐independent apoptosis in human glioma cells

1999 • 82 citations

Age-Related Elevation of Lipid Peroxidation Products: Diminution of Superoxide Dismutase Activity in the Central Nervous System of Rats

1991 • 78 citations

Immunohistochemical Distribution and Electron Microscopic Subcellular Localization of the Proteasome in the Rat CNS

1996 • 78 citations

Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells

1999 • 75 citations

The suppression of age-related accumulation of lipid peroxides in rat brain by administration of Rooibos tea (Aspalathus linearis)

1995 • 72 citations

Multi-Step Activation of NF-κB/Rel Transcription Factors

1995 • 71 citations

Transcription factor NF-κB: friend or foe of neurons?

1998 • 69 citations

Apoptosis and the Proteasome

1999 • 66 citations

Evaluation of neuronal loss, astrocytosis and abnormalities of cytoskeletal components of large motor neurons in the human anterior horn in aging

1998 • 66 citations

Accumulation of β-amyloid precursor protein and ubiquitin in axons after spinal cord trauma in humans: immunohistochemical observations on autopsy material

1996 • 65 citations

Lumbar motor neuron size and number is affected by age in male F344 rats

1998 • 55 citations

Evidence That Spinal Interneurons Undergo Programmed Cell Death Postnatally in the Rat

1997 • 54 citations

Removal of proteasomes from the nucleus and their accumulation in apoptotic blebs during programmed cell death

1996 • 54 citations

Glucose Starvation and Hypoxia Induce Nuclear Accumulation of Proteasome in Cancer Cells

1999 • 35 citations

Changes in Brain Protease Activity in Aging

1996 • 34 citations

SPINAL CORD TRAUMA IN MAN: STUDIES OF PHOSPHORYLATED NEUROFILAMENT AND UBIQUITIN EXPRESSION

1990 • 32 citations

Regional Differences of Serotonin-Mediated Synaptic Plasticity in the Chicken Spinal Cord With Development and Aging

1997 • 25 citations

Related mechanisms of action of growth factors and antioxidants in apoptosis: an overview.

1997 • 22 citations

Opposing Actions of Native and Oxidized Lipoprotein on Motor Neuron-like Cells

1999 • 20 citations

Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells

1999 • 17 citations

Evidence for a Novel ATP-Dependent Protease from the Rat Liver Mitochondrial Intermembrane Space: Purification and Characterisation

1998 • 13 citations