Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex.

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

‘Touchdown’ PCR to circumvent spurious priming during gene amplification

1991 • 2,630 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

Antigen Recognition by Class I-Restricted T Lymphocytes

1989 • 1,207 citations

Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules

1992 • 730 citations

γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

1993 • 572 citations

The multicatalytic and 26 S proteases.

1993 • 476 citations

The multicatalytic proteinase complex, a major extralysosomal proteolytic system

1990 • 464 citations

MHC-linked LMP gene products specifically alter peptidase activities of the proteasome

1993 • 453 citations

A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC

1991 • 427 citations

Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival.

1991 • 421 citations

Proteasomes: multicatalytic proteinase complexes

1993 • 395 citations

Second proteasome-related gene in the human MHC class II region

1991 • 348 citations

Brefeldin A Specifically Inhibits Presentation of Protein Antigens to Cytotoxic T Lymphocytes

1989 • 329 citations

A role for the ubiquitin-dependent proteolytic pathway in MHC class l-restricted antigen presentation

1993 • 317 citations

The multicatalytic proteinase (prosome) is ubiquitous from eukaryotes to archaebacteria

1989 • 277 citations

Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex

1991 • 262 citations

PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins.

1993 • 260 citations

Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene

1991 • 256 citations

Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation

1992 • 250 citations

Primary structure of the Thermoplasma proteasome and its implications for the structure, function, and evolution of the multicatalytic proteinase

1992 • 235 citations

Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules

1992 • 215 citations

Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator.

1994 • 207 citations

Subunit stoichiometry and three-dimensional arrangement in proteasomes from Thermoplasma acidophilum.

1992 • 180 citations

Proteasomes are regulated by interferon gamma: implications for antigen processing.

1992 • 177 citations

Efficient transformation of mammalian cells with constructs containing a puromycin-resistance marker

1988 • 146 citations

The Multicatalytic Proteinase

1989 • 145 citations

The Drosophila proteasome undergoes changes in its subunit pattern during development

1989 • 127 citations

Proteasomes are essential for yeast proliferation. cDNA cloning and gene disruption of two major subunits.

1990 • 127 citations

Localization of subunits in proteasomes from Thermoplasma acidophilum by immunoelectron microscopy

1991 • 123 citations

Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits.

1992 • 119 citations

The transporters associated with antigen presentation

1993 • 118 citations

Major histocompatibility complex (MHC)-encoded HAM2 is necessary for antigenic peptide loading onto class I MHC molecules.

1992 • 111 citations

Proteasomes: protein and gene structures.

1992 • 108 citations

Degradation of oxidized insulin B chain by the multiproteinase complex macropain (proteasome)

1991 • 99 citations

Molecular cloning and functional analysis of three subunits of yeast proteasome.

1991 • 97 citations

Biochemical properties of the proteasome from Thermoplasma acidophilum

1992 • 78 citations

The proteasome/multicatalytic—multifunctional proteinase In vivo function in the ubiquitin‐dependent N‐end rule pathway of protein degradation in eukaryotes

1992 • 76 citations

The major‐histocompatibility‐complex‐encoded β‐type proteasome subunits LMP2 and LMP7

1993 • 61 citations

The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous

1991 • 56 citations

N‐Terminal sequence similarities between components of the multicatalytic proteinase complex

1990 • 56 citations

A controlled breakdown: Antigen processing and the turnover of viral proteins

1992 • 54 citations

MHC-linked low-molecular mass polypeptide subunits define distinct subsets of proteasomes. Implications for divergent function among distinct proteasome subsets.

1993 • 53 citations

Molecular Cloning of cDNAs for Rat Proteasomes: Deduced Primary Structures of Four Other Subunits1

1992 • 30 citations

Isolation and characterization of the MHC linked β‐type proteasome subunit MC13 cDNA

1992 • 29 citations

Molecular Cloning and Functional Analysis of Three Subunits of Yeast Proteasome

1991 • 28 citations