Nonalcoholic Fatty Liver Disease: From Steatosis to Cirrhosis

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2005 • 9,483 citations

Nonalcoholic Fatty Liver Disease

2002 • 5,091 citations

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1999 • 3,605 citations

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2004 • 3,594 citations

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The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study

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Nonalcoholic Steatohepatitis Mayo Clinic Experiences With a Hitherto Unnamed Disease

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2003 • 2,629 citations

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2005 • 2,161 citations

Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference

2003 • 2,157 citations

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

2004 • 2,151 citations

The utility of radiological imaging in nonalcoholic fatty liver disease

2002 • 2,037 citations

Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance

2003 • 2,035 citations

Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities

2001 • 2,021 citations

Mitochondrial Dysfunction and Type 2 Diabetes

2005 • 1,950 citations

Sampling Variability of Liver Biopsy in Nonalcoholic Fatty Liver Disease

2005 • 1,920 citations

Molecular mediators of hepatic steatosis and liver injury

2004 • 1,763 citations

Molecular mediators of hepatic steatosis and liver injury

2004 • 1,709 citations

Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis

1999 • 1,610 citations

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2004 • 1,502 citations

The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years

1990 • 1,475 citations

Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma

2002 • 1,445 citations

Nonalcoholic Fatty Liver Disease: Predictors of Nonalcoholic Steatohepatitis and Liver Fibrosis in the Severely Obese

2001 • 1,341 citations

Mechanism of Hepatic Insulin Resistance in Non-alcoholic Fatty Liver Disease

2004 • 1,276 citations

Prevalence of and Risk Factors for Hepatic Steatosis in Northern Italy

2000 • 1,273 citations

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2005 • 1,243 citations

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1990 • 1,210 citations

Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values

2003 • 1,171 citations

The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

2003 • 1,155 citations

NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome

2002 • 1,131 citations

Nonalcoholic steatohepatitis: An expanded clinical entity

1994 • 1,113 citations

The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

2003 • 1,056 citations

Serum markers detect the presence of liver fibrosis: A cohort study

2004 • 1,039 citations

Beyond insulin resistance in NASH: TNF-? or adiponectin?

2004 • 934 citations

The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies

2004 • 916 citations

Nonalcoholic fatty liver disease

2002 • 894 citations

Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association

2002 • 760 citations

CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis

2000 • 746 citations

Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis

2003 • 740 citations

A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis

2004 • 729 citations

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

2001 • 728 citations

Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss

2004 • 725 citations

Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial

2004 • 723 citations

Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone

2003 • 716 citations

Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis

2003 • 704 citations

Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study

2005 • 698 citations

A Randomized Controlled Trial of Metformin versus Vitamin E or Prescriptive Diet in Nonalcoholic Fatty Liver Disease

2005 • 684 citations

Etiopathogenesis of Nonalcoholic Steatohepatitis

2001 • 678 citations

Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis

1998 • 668 citations

Therapeutic effects of restricted diet and exercise in obese patients with fatty liver

1997 • 624 citations

Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis

1998 • 611 citations

NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States

2002 • 595 citations

Liver Pathology and the Metabolic Syndrome X in Severe Obesity

1999 • 592 citations

Development of Muscle Insulin Resistance After Liver Insulin Resistance in High-Fat–Fed Rats

1991 • 586 citations

Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: A pilot study

1996 • 564 citations

High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: A potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis

2001 • 537 citations

Comparison of liver histology with ultrasonography in assessing diffuse parenchymal liver disease

1991 • 533 citations

Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study

2000 • 532 citations

Liver abnormalities in severely obese subjects: Effect of drastic weight loss after gastroplasty

1998 • 499 citations

Mitochondrial abnormalities in non-alcoholic steatohepatitis

1999 • 494 citations

Natural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies

2004 • 473 citations

Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis

2002 • 471 citations

The natural history of nonalcoholic fatty liver disease: a clinical histopathological study

2003 • 470 citations

Prevalence of non‐alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults

2005 • 446 citations

One-Year Intense Nutritional Counseling Results in Histological Improvement in Patients with Nonalcoholic Steatohepatitis: A Pilot Study

2005 • 446 citations

Long-Term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C

2003 • 439 citations

A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis

2004 • 438 citations

Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life

2004 • 437 citations

Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study

2001 • 428 citations

Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver

2004 • 423 citations

Plasma transforming growth factor‐β1 level and efficacy of α‐tocopherol in patients with non‐alcoholic steatohepatitis: a pilot study

2001 • 415 citations

Adiponectin and its receptors in non-alcoholic steatohepatitis

2004 • 411 citations

Plasma Adiponectin in Nonalcoholic Fatty Liver Is Related to Hepatic Insulin Resistance and Hepatic Fat Content, Not to Liver Disease Severity

2005 • 411 citations

Fatty liver hepatitis and cirrhosis in obese patients

1979 • 405 citations

Adiponectin protects LPS-induced liver injury through modulation of TNF-? in KK-Ay obese mice

2004 • 400 citations

Obesity and hepatocellular carcinoma

2004 • 393 citations

NAFLD may be a common underlying liver disease in patients with hepatocellular Carcinoma in the United States

2002 • 389 citations

Effect of weight reduction on hepatic abnormalities in overweight patients

1990 • 381 citations

Administration of the potent PPARα agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice

2004 • 370 citations

Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis

1999 • 369 citations

Prevalence of fatty liver in a general population of Okinawa, Japan.

1988 • 365 citations

Steatosis: Co-factor in other liver diseases

2005 • 361 citations

Hepatocellular carcinoma in patients with non-alcoholic steatohepatitis

2002 • 358 citations

II. CytochromeP-450 enzymes and oxidative stress

2001 • 353 citations

Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis

2003 • 336 citations

Diagnosis of fatty liver disease

2003 • 334 citations

Recent concepts in non‐alcoholic fatty liver disease

2005 • 328 citations

Apolipoprotein synthesis in nonalcoholic steatohepatitis

2002 • 327 citations

Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis

2003 • 322 citations

Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study

2004 • 315 citations

A high‐fat diet leads to the progression of non‐alcoholic fatty liver disease in obese rats

2004 • 310 citations

Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds

2000 • 298 citations

The Role of Ultrasound in the Diagnosis of Hepatic Steatosis in Morbidly Obese Patients

2004 • 291 citations

Selection and Outcome of Living Donors for Adult to Adult Right Lobe Transplantation

2000 • 278 citations

NF-κB Activation, Rather Than TNF, Mediates Hepatic Inflammation in a Murine Dietary Model of Steatohepatitis

2005 • 273 citations

Fatty liver in non‐alcoholic non‐overweight Japanese adults: Incidence and clinical characteristics

2002 • 273 citations

Hepatic MRI for Fat Quantitation

2005 • 271 citations

Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease

2001 • 266 citations

HFE mutations, hepatic iron, and fibrosis: Ethnic-specific association of NASH with C282Y but not with fibrotic severity

2002 • 250 citations

Liver Histology in a ‘Normal’ Population—Examinations of 503 Consecutive Fatal Traffic Casualties

1977 • 249 citations

Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction

2004 • 244 citations

Hepatic iron and nonalcoholic fatty liver disease

1999 • 240 citations

Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis

2003 • 238 citations

A Pilot Trial of Pentoxifylline in Nonalcoholic Steatohepatitis

2004 • 236 citations

Non‐alcoholic steatohepatitis: What is it, and why is it important in the Asia–Pacific region?

2003 • 233 citations

Cytokines and the pathogenesis of non-alcoholic steatohepatitis

2005 • 222 citations

Dietary Composition and Nonalcoholic Fatty Liver Disease

2004 • 217 citations

Steatohepatitis induced by intragastric overfeeding in mice

2005 • 213 citations

Hyaluronic acid, an accurate serum marker for severe hepatic fibrosis in patients with non‐alcoholic fatty liver disease

2005 • 213 citations

Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice

2004 • 199 citations

The Pathogenesis of Nonalcoholic Steatohepatitis and Other Fatty Liver Diseases: A Four-Step Model including the Role of Lipid Release and Hepatic Venular Obstruction in the Progression to Cirrhosis

2004 • 197 citations

Hepatocyte CYP2E1 Overexpression and Steatohepatitis Lead to Impaired Hepatic Insulin Signaling

2005 • 194 citations

Insulin resistance and C‐reactive protein as independent risk factors for non‐alcoholic fatty liver disease in non‐obese Asian men

2004 • 192 citations

Non‐alcoholic fatty liver syndrome: A hepatic consequence of common metabolic diseases

2003 • 190 citations

Body fat topography as an independent predictor of fatty liver

1993 • 179 citations

Fibrosis in Patients with Chronic Hepatitis C: Detection and Significance

2000 • 176 citations

Cryptogenic cirrhosis: Clinicopathologic findings at and after liver transplantation

2002 • 173 citations

Regression of Hepatic Steatosis in Morbidly Obese Persons After Gastric Bypass

1995 • 167 citations

Fatty Liver Disease

2004 • 160 citations

Alcohol consumption and the risk of alcohol related cirrhosis in women.

1987 • 155 citations

Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat?

2005 • 153 citations

Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease

2005 • 153 citations

Pathologic features associated with fibrosis in nonalcoholic fatty liver disease

2004 • 144 citations

Non‐alcoholic steatohepatitis in children and adolescents

2000 • 144 citations

Diabetes duration and cause-specific mortality in the Verona Diabetes Study.

2000 • 139 citations

Focal manifestations of diffuse liver disease at MR imaging.

1992 • 124 citations

Efficacy and Safety of Oral Betaine Glucuronate in Non-alcoholic Steatohepatitis

2011 • 105 citations

Controversies in liver biopsy: Who, where, when, how, why?

2004 • 102 citations

Subacute liver failure in obese women

2002 • 92 citations

The effect of donor weight reduction on hepatic steatosis for living donor liver transplantation

2004 • 89 citations

Are there Predictive Factors of Severe Liver Fibrosis in Morbidly Obese Patients with Non-alcoholic Steatohepatitis?

2001 • 86 citations

Fasting in obesity

1982 • 79 citations

Contribution of metabolic factors to alanine aminotransferase activity in persons with other causes of liver disease

2005 • 79 citations

Liver pathology in aircrew.

1982 • 73 citations

Liver injury in the setting of steatosis: Crosstalk between adipokine and cytokine

2004 • 72 citations

Proposal for a histological scoring and grading system for non‐alcoholic fatty liver disease

2005 • 67 citations

Cognitive Lifetime Drinking History in Nonalcoholic Fatty Liver Disease: Some Cases May Be Alcohol Related

2004 • 61 citations

Liver Transplantation in Cirrhotic Patients with Small Hepatocellular Carcinoma: An Analysis of Pre-Operative Imaging, Explant Histology and Prognostic Histologic Indicators

2004 • 60 citations

Hepatic stellate cells and fibrosis progression in patients with nonalcoholic fatty liver disease

2005 • 59 citations

Steatohepatitis in children

2002 • 59 citations

The association of coronary calcium score and conventional cardiovascular risk factors in Type 2 diabetic subjects asymptomatic for coronary heart disease (The PREDICT Study)

2004 • 58 citations

Signalling links in the liver: Knitting SOCS with fat and inflammation

2005 • 53 citations

Prevalence of transaminase abnormalities in asymptomatic, healthy subjects participating in an executive health-screening program.

2003 • 50 citations

Comparison of Hepatocellular Carcinoma Patients With Alcoholic Liver Disease and Nonalcoholic Steatohepatitis

2004 • 38 citations

Comparison of Hepatocellular Carcinoma Patients With Alcoholic Liver Disease and Nonalcoholic Steatohepatitis

2004 • 37 citations

The value of ultrasonography and computerized tomography in estimating the histopathological severity of nonalcoholic steatohepatitis.

2005 • 26 citations

Transient focal fatty liver infiltration mimicking liver metastasis.

1998 • 10 citations