Signalling links in the liver: Knitting SOCS with fat and inflammation

Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome

2003 • 2,629 citations

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

2005 • 2,161 citations

NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome

2002 • 1,131 citations

SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2

2002 • 874 citations

Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms

2004 • 646 citations

Suppressor of Cytokine Signaling-3 (SOCS-3), a Potential Mediator of Interleukin-6-dependent Insulin Resistance in Hepatocytes

2003 • 604 citations

SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice

2001 • 449 citations

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity

2004 • 409 citations

Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse

2004 • 373 citations

Protein tyrosine phosphatases: the quest for negative regulators of insulin action

2003 • 188 citations

Expression of suppressors of cytokine signaling during liver regeneration

2001 • 152 citations