High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: A potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis

Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity☆, ☆☆

1999 • 3,339 citations

Nonalcoholic Steatohepatitis Mayo Clinic Experiences With a Hitherto Unnamed Disease

1980 • 2,667 citations

Intraobserver and Interobserver Variations in Liver Biopsy Interpretation in Patients with Chronic Hepatitis C

1994 • 1,968 citations

Association of nonalcoholic fatty liver disease with insulin resistance

1999 • 1,560 citations

The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years

1990 • 1,475 citations

Nonalcoholic steatohepatitis: An expanded clinical entity

1994 • 1,113 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Liver fibrosis in overweight patients

2000 • 966 citations

Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.

1991 • 878 citations

Stimulation of Fibroblast Cell Growth, Matrix Production, and Granulation Tissue Formation by Connective Tissue Growth Factor

1996 • 754 citations

Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair.

1993 • 706 citations

FATTY, A NEW MUTATION IN THE RAT

1961 • 595 citations

Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta.

1994 • 593 citations

Nonalcoholic steatohepatitis: A study of 49 patients

1989 • 555 citations

Expression of connective tissue growth factor in human renal fibrosis

1998 • 545 citations

A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene.

1996 • 526 citations

Alcohollike liver disease in nonalcoholics

1988 • 485 citations

Connective Tissue Growth Factor Gene Expression in Tissue Sections From Localized Scleroderma, Keloid, and Other Fibrotic Skin Disorders

1996 • 438 citations

Fatty liver hepatitis and cirrhosis in obese patients

1979 • 405 citations

Suppression Subtractive Hybridization Identifies High Glucose Levels as a Stimulus for Expression of Connective Tissue Growth Factor and Other Genes in Human Mesangial Cells

1999 • 395 citations

Regulation of Connective Tissue Growth Factor Activity in Cultured Rat Mesangial Cells and Its Expression in Experimental Diabetic Glomerulosclerosis

2000 • 390 citations

Increased gastrointestinal ethanol production in obese mice: Implications for fatty liver disease pathogenesis

2000 • 341 citations

Expression of connective tissue growth factor in experimental rat and human liver fibrosis

1999 • 326 citations

Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas.

1992 • 311 citations

Nonalcoholic fatty liver disease: assessment of variability in pathologic interpretations.

1998 • 308 citations

Human Connective Tissue Growth Factor Is Expressed in Advanced Atherosclerotic Lesions

1997 • 301 citations

Expression of cyr61, a growth factor-inducible immediate-early gene.

1990 • 291 citations

The synthesis of proteoglycans in fat-storing cells of rat liver

1987 • 259 citations

Cyr61 and Fisp12 Are Both ECM-Associated Signaling Molecules: Activities, Metabolism, and Localization during Development

1997 • 240 citations

Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein.

1991 • 203 citations

TGF‐β stimulates primary human skin fibroblast DNA synthesis via an autocrine production of PDGF‐related peptides

1989 • 154 citations

High Glucose Stimulates Proliferation and Collagen Type I Synthesis in Renal Cortical Fibroblasts

1999 • 143 citations

Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells

2000 • 138 citations

Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-beta1 and detection in human gingiva.

1999 • 137 citations

Connective tissue growth factor in human liver cirrhosis

2000 • 104 citations

Hepatic Free Fatty Acids in Alcoholic Liver Disease and Morbid Obesity

1983 • 97 citations

Expression of cyr61, a Growth Factor-Inducible Immediate-Early Gene

1990 • 96 citations

Nonalcoholic steatohepatitis: An expanded clinical entity

1993 • 90 citations

High glucose increases growth and collagen synthesis in cultured human tubulointerstitial cells

1999 • 62 citations

Expression of connective tissue growth factor in human renal fibrosis

1998 • 41 citations

Fatty liver hepatitis and cirrhosis in obese patients

1979 • 18 citations