Steatohepatitis in children

Health Consequences of Obesity in Youth: Childhood Predictors of Adult Disease

1998 • 2,777 citations

Nonalcoholic Steatohepatitis Mayo Clinic Experiences With a Hitherto Unnamed Disease

1980 • 2,667 citations

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis*

1997 • 2,442 citations

Elevated C-Reactive Protein Levels in Overweight and Obese Adults

1999 • 2,384 citations

Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities

2001 • 2,021 citations

Association of nonalcoholic fatty liver disease with insulin resistance

1999 • 1,560 citations

The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years

1990 • 1,475 citations

Epidemic Increase in Childhood Overweight, 1986-1998

2001 • 1,210 citations

Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors

1990 • 1,210 citations

Type 2 diabetes among North adolescents: An epidemiologic health perspective

2000 • 1,146 citations

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis

1997 • 1,134 citations

Nonalcoholic steatohepatitis: An expanded clinical entity

1994 • 1,113 citations

The Syndromes of Insulin Resistance and Acanthosis Nigricans

1976 • 1,086 citations

Nonalcoholic Steatohepatitis: Definition and Pathology

2001 • 919 citations

The natural history of nonalcoholic fatty liver: A follow-up study

1995 • 898 citations

Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy

1994 • 854 citations

Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis

1997 • 815 citations

Identification of the gene altered in Berardinelli–Seip congenital lipodystrophy on chromosome 11q13

2001 • 714 citations

Review: Measurement and long-term health risks of child and adolescent fatness

1997 • 702 citations

The relation of body fat mass and distribution to markers of chronic inflammation

2001 • 699 citations

LMNA, encoding lamin A/C, is mutated in partial lipodystrophy

2000 • 688 citations

Etiopathogenesis of Nonalcoholic Steatohepatitis

2001 • 678 citations

Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis

1998 • 668 citations

Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: A pilot study

1996 • 564 citations

Nonalcoholic steatohepatitis: A study of 49 patients

1989 • 555 citations

The Cardinal Manifestations of Bardet–Biedl Syndrome, a Form of Laurence–Moon–Biedl Syndrome

1989 • 541 citations

High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: A potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis

2001 • 537 citations

Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study

2000 • 532 citations

Homozygous Defects in LMNA, Encoding Lamin A/C Nuclear-Envelope Proteins, Cause Autosomal Recessive Axonal Neuropathy in Human (Charcot-Marie-Tooth Disorder Type 2) and Mouse

2002 • 530 citations

Secular trends in the body mass index of Canadian children.

2000 • 478 citations

Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study

2001 • 428 citations

Nonalcoholic Steatohepatitis in Children

2000 • 420 citations

Prevalence of fatty liver in Japanese children and relationship to obesity

1995 • 413 citations

Fatty liver hepatitis and cirrhosis in obese patients

1979 • 405 citations

Mitochondria in Steatohepatitis

2001 • 404 citations

Low-Grade Systemic Inflammation in Overweight Children

2001 • 404 citations

Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease

2001 • 400 citations

Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis

2001 • 399 citations

Effect of weight reduction on hepatic abnormalities in overweight patients

1990 • 381 citations

Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis

1999 • 369 citations

Prevelance of abnormal serum aminotransferase values in overweight and obese adolescents

2000 • 332 citations

A Low–Glycemic Index Diet in the Treatment of Pediatric Obesity

2000 • 309 citations

Natural history of liver disease in cystic fibrosis

1999 • 306 citations

Early metabolic abnormalities in adolescent girls with polycystic ovarian syndrome

2001 • 296 citations

Idiopathic steatohepatitis in childhood: A multicenter retrospective study

1995 • 294 citations

Non-alcoholic fatty liver: another feature of the metabolicsyndrome?

1999 • 294 citations

Epidemiology of childhood obesity in Europe

2000 • 289 citations

V. Mitochondrial dysfunction in steatohepatitis

2002 • 282 citations

Identification of the gene that, when mutated, causes the human obesity syndrome BBS4

2001 • 271 citations

A Novel Heterozygous Mutation in Peroxisome Proliferator-Activated Receptor-γ Gene in a Patient with Familial Partial Lipodystrophy

2002 • 268 citations

Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease

2001 • 266 citations

Impaired mitochondrial function in microvesicular steatosis effects of drugs, ethanol, hormones and cytokines

1997 • 261 citations

Cryptogenic cirrhosis and posttransplantation nonalcoholic fatty liver disease

2001 • 260 citations

Metformin therapy is associated with a decrease in plasma plasminogen activator inhibitor-1, lipoprotein(a), and immunoreactive insulin levels in patients with the polycystic ovary syndrome

1997 • 255 citations

Non-alcoholic steatohepatitis: association with obesity and insulin resistance, and influence of weight loss.

2000 • 248 citations

Obese children with steatohepatitis can develop cirrhosis in childhood

2002 • 240 citations

Long-term survivors of childhood cancer have an increased risk of manifesting the metabolic syndrome.

1996 • 233 citations

Changes in body mass index and prevalence of overweight in survivors of childhood acute lymphoblastic leukemia: Role of cranial irradiation

2000 • 218 citations

Steatohepatitis in obese children: a cause of chronic liver dysfunction.

1983 • 215 citations

C-reactive protein is independently associated with total body fat, central fat, and insulin resistance in adult women

2001 • 205 citations

Persistent hyperaminotransferasemia resolving after weight reduction in obese children

1994 • 202 citations

Comparison of serum concentrations of α-tocopherol and β-carotene in a cross-sectional sample of obese and nonobese children (NHANES III)

1999 • 200 citations

Lipoatrophy Revisited

2000 • 193 citations

Childhood obesity in Europe: a growing concern

2001 • 191 citations

Excess Insulin Binding to Insulin-Like Growth Factor Receptors: Proposed Mechanism for Acanthosis Nigricans

1992 • 190 citations

Fatty Liver and Its Fibrous Changes Found in Simple Obesity of Children

1984 • 189 citations

Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents

2000 • 186 citations

Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30

2001 • 181 citations

Hepatocellular carcinoma arising in non‐alcoholic steatohepatitis

2001 • 177 citations

Exploring the molecular basis of Bardet-Biedl syndrome

2001 • 169 citations

Cost-effectiveness of group and mixed family-based treatment for childhood obesity

2001 • 166 citations

Asparaginase-Associated Lipid Abnormalities in Children With Acute Lymphoblastic Leukemia

1997 • 164 citations

Alström syndrome

1998 • 152 citations

Cohen Syndrome: Essential features, natural history, and heterogeneity

2001 • 148 citations

Obesity after Successful Treatment of Acute Lymphoblastic Leukemia in Childhood

1995 • 146 citations

Non‐alcoholic steatohepatitis in children and adolescents

2000 • 144 citations

Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study

2000 • 142 citations

Serum alanine aminotransferase activity in obese children

1997 • 141 citations

Acanthosis Nigricans as a Risk Factor for Non-Insulin Dependent Diabetes Mellitus

1998 • 139 citations

Patterns of obesity in boys and girls after treatment for acute lymphoblastic leukaemia.

1994 • 136 citations

Lack of efficacy of ursodeoxycholic acid for the treatment of liver abnormalities in obese children

2000 • 135 citations

Treatment of Nonalcoholic Fatty Liver: Present and Emerging Therapies

2001 • 127 citations

A Fifth Locus for Bardet-Biedl Syndrome Maps to Chromosome 2q31

1999 • 126 citations

Abnormal Biliary Lipid Composition in Cystic Fibrosis

1977 • 119 citations

Direct transesterification of plasma fatty acids for the diagnosis of essential fatty acid deficiency in cystic fibrosis.

1989 • 118 citations

Energy Expenditure, Energy Intake and Prevalence of Obesity after Therapy for Acute Lymphoblastic Leukemia during Childhood

2000 • 110 citations

Phenotypic differences among patients with Bardet‐Biedl syndrome linked to three different chromosome loci

1995 • 104 citations

Obesity, acanthosis nigricans, insulin resistance, and hyperandrogenemia: Pediatric perspective and natural history

1985 • 103 citations

Natural history of Alström syndrome in early childhood: Onset with dilated cardiomyopathy

1996 • 102 citations

A Novel Heterozygous Mutation in Peroxisome Proliferator-Activated Receptor- Gene in a Patient with Familial Partial Lipodystrophy

2002 • 96 citations

Recurrent nonalcoholic steatohepatitis and cirrhosis after liver transplantation

1997 • 95 citations

Long-term survivors of childhood cancer have an increased risk of manifesting the metabolic syndrome

1996 • 89 citations

Supplementation with carotenoids corrects increased lipid peroxidation in children with cystic fibrosis

1996 • 89 citations

Reduced plasma concentrations of alpha- tocopherol and beta-carotene in obese boys

1997 • 87 citations

Risk factors for excess weight gain in children treated for acute lymphoblastic leukaemia

2000 • 84 citations

Prevalence of acanthosis nigricans and its association with hyperinsulinemia in New Mexico adolescents11The full text of this article is available via JAH Online at http://www.elsevier.com/locate/jahonline.

2001 • 82 citations

Prader-Willi and other syndromes associated with obesity and mental retardation.

1997 • 80 citations

Genealogy, natural history, and phenotype of Alström syndrome in a large Acadian kindred and three additional families

1997 • 79 citations

Clinical aspects of obesity in childhood and adolescence—diagnosis, treatment and prevention

2001 • 78 citations

A method of predicting adult height and obesity in long-term survivors of childhood acute lymphoblastic leukemia.

1992 • 77 citations

Steatohepatitis associated with limb lipodystrophy

1989 • 75 citations

Genetic Heterogeneity of Bardet–Biedl Syndrome in a Distinct Canadian Population: Evidence for a Fifth Locus

1999 • 69 citations

Ursodeoxycholic acid improves the hepatic metabolism of essential fatty acids and retinol in children with cystic fibrosis

1997 • 62 citations

Prevalence of Protein-Energy Malnutrition at Diagnosis in Children with Acute Lymphoblastic Leukemia

1999 • 60 citations

Liver involvement in cystic fibrosis

1999 • 54 citations

Hepatic involvement in the Bardet‐Biedl syndrome

1982 • 52 citations

Metformin improves ovulation and pregnancy rates in patients with polycystic ovary syndrome

2001 • 52 citations

The Alstrom syndrome: ophthalmic histopathology and retinal ultrastructure.

1984 • 51 citations

Liver abnormalities in Turner syndrome

1999 • 51 citations

Insulin resistance in clomiphene responders and non‐responders with polycystic ovarian disease and therapeutic effects of metformin

2001 • 49 citations

LIPOATROPHIC DIABETES AND END-STAGE LIVER DISEASE SECONDARY TO NONALCOHOLIC STEATOHEPATITIS WITH RECURRENCE AFTER LIVER TRANSPLANTATION

2001 • 47 citations

Hepatic dysfunction in two sibs with Alström syndrome: Case report and review of the literature

1997 • 46 citations

OBESITY IN LEUKEMIA SURVIVORS: The Familial Contribution

2000 • 42 citations

Hepatic dysfunction in Alström disease

1991 • 42 citations

Metformin therapy in the management of polycystic ovary syndrome: endocrine ,metabolic and reproductive effects

2001 • 41 citations

The molecular genetics of Bardet–Biedl syndrome

2001 • 37 citations

Massive Hepatomegaly, Steatosis, and Secondary Plasma Carnitine Deficiency in an Infant With Cystic Fibrosis

1989 • 37 citations

Lack of efficacy of ursodeoxycholic acid for the treatment of liver abnormalities in obese children

2000 • 34 citations

Acanthosis Nigricans: A Marker for Hyperinsulinemia

1995 • 32 citations

Early-onset liver disease complicated with acute liver failure in Alstrom syndrome

2001 • 31 citations

Resting metabolic rate and obesity in childhood acute lymphoblastic leukaemia.

1996 • 29 citations

Familial insulin resistant diabetes associated with acanthosis nigricans, polycystic ovaries, hypogonadism, pigmentary retinopathy, labyrinthine deafness, and mental retardation

1993 • 28 citations

A Family With the Bardet-Biedl Syndrome and Diabetes Mellitus

1989 • 27 citations

Frequency and significance of phenotypes for alpha1-antitrypsin deficiency in type 1 autoimmune hepatitis.

1998 • 24 citations

Acanthosis nigricans in obese women with the polycystic ovary syndrome: disease spectrum not distinct entity

1990 • 22 citations

Plasmolipin: genomic structure, chromosomal localization, protein expression pattern, and putative association with Bardet-Biedl syndrome

2001 • 21 citations

Clinical characteristics and factors affecting growth in long-term survivors of cancer

1996 • 20 citations

Alstrom syndrome in two siblings.

2001 • 17 citations

A patient with features of both Bardet-Biedl and Alström syndromes

1990 • 17 citations

Metformin therapy for diabetes in Prader-Willi syndrome

1998 • 16 citations

Acanthosis Nigricans Associated with Hepatolenticular Degeneration

1997 • 10 citations

A 27-year-old woman with Alström syndrome who had liver cirrhosis.

1995 • 9 citations

Troglitazone ameliorates insulin resistance in a diabetic patient with Prader–Willi syndrome

1998 • 8 citations

Acute lymphoblastic leukemia in one of two siblings with Alstrom syndrome.

2000 • 8 citations

Cohen Syndrome with Acanthosis Nigricans and Insulin Resistance

2001 • 8 citations

Alström Syndrome With Subclinical Insulin-Resistant Diabetes and Hepatic Dysfunction: A Family Report

2000 • 8 citations

Prevalence of obesity in young adults with acute lymphoblastic leukemia

1994 • 7 citations

Alstrom syndrome with hepatic dysfunction: report of one case.

2000 • 7 citations

[Effects of metformin on insulin resistance and on ovarian steroidogenesis in women with polycystic ovary syndrome].

2001 • 7 citations

When a child can’t clean her neck

2001 • 4 citations