Interleukin‐17: the missing link between T‐cell accumulation and effector cell actions in rheumatoid arthritis?

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Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

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IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

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Increased expression of interleukin 17 in inflammatory bowel disease

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1986 • 1,591 citations

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.

1996 • 1,496 citations

The Th1/Th2 paradigm

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Antigen-Specific T Cell Sensitization Is Impaired in IL-17-Deficient Mice, Causing Suppression of Allergic Cellular and Humoral Responses

2002 • 1,063 citations

Human IL-17: a novel cytokine derived from T cells.

1995 • 1,014 citations

Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor

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Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis

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IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages.

1998 • 954 citations

Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

1999 • 943 citations

Inhibition of the production and effects of interleukins‐1 and tumor necrosis factor α in rheumatoid arthritis

1995 • 917 citations

Neutrophil Recruitment by Human IL-17 Via C-X-C Chemokine Release in the Airways

1999 • 881 citations

IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages

1998 • 810 citations

CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene.

1993 • 751 citations

Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications

1996 • 647 citations

Quantitative analysis of cytokine gene expression in rheumatoid arthritis.

1990 • 610 citations

Microbial Lipopeptides Induce the Production of IL-17 in Th Cells

2000 • 589 citations

High Levels of IL-17 in Rheumatoid Arthritis Patients: IL-15 Triggers In Vitro IL-17 Production Via Cyclosporin A-Sensitive Mechanism

2000 • 588 citations

Interleukin-17 and Interferon-γ Synergize in the Enhancement of Proinflammatory Cytokine Production by Human Keratinocytes

1998 • 565 citations

How important are t cells in chronic rheumatoid synovitis?

1990 • 553 citations

Enhancing Effect of IL-17 on IL-1-Induced IL-6 and Leukemia Inhibitory Factor Production by Rheumatoid Arthritis Synoviocytes and Its Regulation by Th2 Cytokines

1998 • 451 citations

IL-17 Is Produced by Some Proinflammatory Th1/Th0 Cells But Not by Th2 Cells

1999 • 415 citations

Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo.

1996 • 415 citations

The role of nitric oxide in inflammation and immunity

1998 • 413 citations

Nitric Oxide Activates Metalloprotease Enzymes in Articular Cartilage

1995 • 410 citations

IL-1-Independent Role of IL-17 in Synovial Inflammation and Joint Destruction During Collagen-Induced Arthritis

2001 • 396 citations

Divergent T-cell cytokine patterns in inflammatory arthritis.

1994 • 388 citations

Interleukin-17-induced Gene Expression in Articular Chondrocytes Is Associated with Activation of Mitogen-activated Protein Kinases and NF-κB

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TNFα—A PIVOTAL ROLE IN RHEUMATOID ARTHRITIS?

1992 • 377 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

Nitric-Oxide Mediates Suppression of Cartilage Proteoglycan Synthesis by Interleukin-1

1994 • 374 citations

IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-gamma and TNF-alpha.

1999 • 361 citations

Requirement of Tumor Necrosis Factor Receptor–Associated Factor (Traf)6 in Interleukin 17 Signal Transduction

2000 • 342 citations

IL-17 Promotes Bone Erosion in Murine Collagen-Induced Arthritis Through Loss of the Receptor Activator of NF-κB Ligand/Osteoprotegerin Balance

2003 • 342 citations

IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis

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Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis?

1997 • 322 citations

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1990 • 318 citations

Shift toward T lymphocytes with a T helper 1 cytokine‐secretion profile in the joints of patients with rheumatoid arthritis

1996 • 299 citations

Evidence for a Role of IL-17 in Organ Allograft Rejection: IL-17 Promotes the Functional Differentiation of Dendritic Cell Progenitors

1999 • 297 citations

Interleukin-17 is Produced by Both Th1 and Th2 Lymphocytes, and Modulates Interferon-γ- and Interleukin-4-Induced Activation of Human Keratinocytes

2000 • 289 citations

NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells.

1999 • 288 citations

IL-17 Is Produced by Nickel-Specific T Lymphocytes and Regulates ICAM-1 Expression and Chemokine Production in Human Keratinocytes: Synergistic or Antagonist Effects with IFN-γ and TNF-α

1999 • 284 citations

MOLECULAR CHARACTERIZATION OF THE HUMAN INTERLEUKIN (Il)-17 RECEPTOR

1997 • 282 citations

CONTRIBUTION OF INTERLEUKIN 17 TO SYNOVIUM MATRIX DESTRUCTION IN RHEUMATOID ARTHRITIS

2000 • 278 citations

Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin‐17 receptor IgG1 Fc fusion protein

2002 • 253 citations

NF-κB-Inducing Kinase Is a Common Mediator of IL-17-, TNF-α-, and IL-1β-Induced Chemokine Promoter Activation in Intestinal Epithelial Cells

1999 • 252 citations

Interleukin-17 enhances tumor necrosis factor ?-induced synthesis of interleukins 1, 6, and 8 in skin and synovial fibroblasts: A possible role as a ?fine-tuning cytokine? in inflammation processes

2001 • 246 citations

IL-17 stimulates inflammatory responses via NF-κB and MAP kinase pathways in human colonic myofibroblasts

2002 • 211 citations

Interleukin-1, tumor necrosis factor ?, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci

2001 • 204 citations

Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines

2002 • 202 citations

Learning from lesions: patterns of tissue inflammation in leprosy.

1988 • 199 citations

The combination of tumor necrosis factor ? blockade with interleukin-1 and interleukin-17 blockade is more effective for controlling synovial inflammation and bone resorption in an ex vivo model

2001 • 198 citations

Increased IL-1β, IL-8, and IL-17 mRNA Expression in Blood Mononuclear Cells Observed in a Prospective Ischemic Stroke Study

1999 • 190 citations

IL‐17‐induced cytokine release in human bronchial epithelial cells in vitro: role of mitogen‐activated protein (MAP) kinases

2001 • 189 citations

THE NEUTROPHIL IN RHEUMATOID ARTHRITIS

1995 • 186 citations

Interleukin‐17 up‐regulation of nitric oxide production in human osteoarthritis cartilage

1997 • 183 citations

Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target

1997 • 181 citations

Detection of cytokine producing cells in the synovial membrane from patients with rheumatoid arthritis.

1995 • 176 citations

Retracted: Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection

2002 • 170 citations

Interleukin-17: A New Bone Acting Cytokine In Vitro

1999 • 167 citations

Role of cytokines, acute-phase proteins, and chemokinesin the progression of rheumatoid arthritis

1996 • 166 citations

Mitogen-activated protein kinase and nuclear factor ?B together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes: Possible role of transactivating factor mitogen-activated protein kinase-activated protein kinase (MAPKAPK)

1999 • 163 citations

Stimulation of 92‐kd gelatinase (matrix metalloproteinase 9) production by interleukin‐17 in human monocyte/macrophages: A possible role in rheumatoid arthritis

2000 • 157 citations

Imbalance between interstitial collagenase and tissue inhibitor of metalloproteinases 1 in synoviocytes and fibroblasts upon direct contact with stimulated T lymphocytes: Involvement of membrane-associated cytokines

1998 • 152 citations

Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction

2002 • 151 citations

Synergistic activity of interleukin-4 and interleukin-10 in suppression of inflammation and joint destruction in rheumatoid arthritis

2001 • 148 citations

Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: A possible role in rheumatoid arthritis

2000 • 145 citations

Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines

1993 • 112 citations

Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro

2002 • 111 citations

Regulation of tumor necrosis factor-alpha and IL-1 beta synthesis by thromboxane A2 in nonadherent human monocytes.

1997 • 111 citations

Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis

2002 • 110 citations

Evidence for the Involvement of JAK/STAT Pathway in the Signaling Mechanism of Interleukin-17

1999 • 107 citations

High in vivo expression of interleukin‐17 receptor in synovial endothelial cells and chondrocytes from arthritis patients

2001 • 101 citations

Reduction of interleukin‐17–induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin‐4

2000 • 100 citations

INCREASED EXPRESSION OF INTERFERON (IFN)-GAMMA TOGETHER WITH IFN-GAMMA RECEPTOR IN THE RHEUMATOID SYNOVIAL MEMBRANE COMPARED WITH SYNOVIUM OF PATIENTS WITH OSTEOARTHRITIS

1996 • 79 citations

Effect of interleukin 17 on proteoglycan degradation in murine knee joints

2000 • 74 citations

Is interleukin 17, an inducible cytokine that stimulates production of other cytokines, merely a redundant player in a sea of other biomolecules?

1996 • 67 citations

Effect of interleukin-17 on nitric oxide production and osteoclastic bone resorption: is there dependency on nuclear factor-κB and receptor activator of nuclear factor κB (RANK)/RANK ligand signaling?

2001 • 62 citations

Antigen-induced IL-17 response in the peripheral blood mononuclear cells (PBMC) of healthy controls

2000 • 60 citations

REGULATION OF IL-17, IFN-γ AND IL-10 IN HUMAN CD8+T CELLS BY CYCLIC AMP-DEPENDENT SIGNAL TRANSDUCTION PATHWAY

1998 • 60 citations

Cooperation of interleukin-17 and interferon-γon chemokine secretion in human fetal intestinal epithelial cells

2001 • 59 citations

Modulation of TIMP-1 synthesis by antiinflammatory cytokines and prostaglandin E2 in interleukin 17 stimulated human monocytes/macrophages.

2001 • 48 citations

Interleukin 17, a nitric oxide-producing cytokine with a peroxynitrite-independent inhibitory effect on proteoglycan synthesis.

2002 • 38 citations

Low-Level Production of Interleukin-13 in Synovial Fluid and Tissue from Patients with Arthritis

1997 • 26 citations

Addition of interleukin 1 (IL1) and IL17 soluble receptors to a tumour necrosis factor alpha soluble receptor more effectively reduces the production of IL6 and macrophage inhibitory protein-3alpha and increases that of collagen in an in vitro model of rheumatoid synoviocyte activation

2002 • 25 citations

Cell-cell contact of human T cells with fibroblasts changes lymphocytic mRNA expression: increased mRNA expression of interleukin-17 and interleukin-17 receptor.

2000 • 14 citations

Interleukin-17 may have a central role in inflammatory joint diseases as a "fine-tuning" cytokine.

2000 • 6 citations