THE NEUTROPHIL IN RHEUMATOID ARTHRITIS

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.

1989 • 1,993 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

Chlorination of Taurine by Human Neutrophils

1982 • 794 citations

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.

1992 • 727 citations

Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules.

1991 • 675 citations

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

1993 • 658 citations

New roles for G-protein (βγ-dimers in transmembrane signalling

1993 • 633 citations

Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.

1976 • 573 citations

Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum

1988 • 570 citations

Inflammation: Basic Principles and Clinical Correlates

1993 • 518 citations

Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.

1989 • 514 citations

Neutrophil-activating protein 1/interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD11b/CD18 on human neutrophils.

1990 • 478 citations

Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration

1992 • 477 citations

Oxidative Autoactivation of Latent Collagenase by Human Neutrophils

1985 • 466 citations

Phagocytosing neutrophils produce and release high amounts of the neutrophil-activating peptide 1/interleukin 8.

1991 • 442 citations

Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation.

1990 • 435 citations

Regulation of interleukin 8 gene expression by oxidant stress.

1993 • 395 citations

Arthritis and Allied Conditions

1993 • 392 citations

Human neutrophils increase expression of C3bi as well as C3b receptors upon activation.

1984 • 391 citations

Nitric-Oxide Mediates Suppression of Cartilage Proteoglycan Synthesis by Interleukin-1

1994 • 374 citations

Effect of oxygen‐derived free radicals on hyaluronic acid

1980 • 368 citations

IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro.

1990 • 361 citations

Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells.

1991 • 336 citations

Novel cytochrome b system in phagocytic vacuoles of human granulocytes

1978 • 335 citations

In vitro synthesis of immunoglobulin by rheumatoid synovial membrane

1968 • 324 citations

Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1.

1989 • 298 citations

Inflammation: Basic Principles and Clinical Correlates

1988 • 275 citations

Chemotaxis of polymorphonuclear leukocytes from patients with rheumatoid arthritis

1971 • 268 citations

Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule 1

1994 • 263 citations

The adhesion molecules of inflammation

1993 • 257 citations

Histopathology of the rheumatoid lesion

1984 • 241 citations

Interleukin-8 induces neutrophil transendothelial migration.

1991 • 238 citations

Leukotriene B4 is a complete secretagogue in human neutrophils: A kinetic analysis

1982 • 237 citations

Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1.

1993 • 223 citations

Aspirin

1991 • 219 citations

Modes of action of aspirin-like drugs.

1985 • 218 citations

Changes in membrane potential of human granulocytes antecede the metabolic responses to surface stimulation

1978 • 218 citations

Carboxyl Methylation of Ras-Related Proteins During Signal Transduction in Neutrophils

1993 • 212 citations

Autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis

1985 • 207 citations

Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases.

1993 • 201 citations

Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia.

1991 • 198 citations

Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes.

1992 • 183 citations

Low levels of interleukin‐4 and high levels of transforming growth factor β in rheumatoid synovitis

1990 • 181 citations

Stimulus response coupling in the human neutrophil. I. Kinetic analysis of changes in calcium permeability.

1984 • 177 citations

Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. ii. low levels of synovial fluid and synovial tissue interferon suggest that γgm‐interferon is not the primary macrophage activating factor

1987 • 177 citations

Neutrophil and monocyte adherence to and migration across monolayers of cytokine-activated endothelial cells: the contribution of CD18, ELAM-1, and VLA-4

1991 • 175 citations

Role of endothelial leukocyte adhesion molecule-1 and platelet-activating factor in neutrophil adherence to IL-1-prestimulated endothelial cells. Endothelial leukocyte adhesion molecule-1-mediated CD18 activation.

1991 • 168 citations

Secreted forms of human neutrophil collagenase.

1986 • 167 citations

Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation.

1988 • 161 citations

The Genesis of Ores

1991 • 157 citations

Expression of interleukin-1 alpha and beta genes by human blood polymorphonuclear leukocytes.

1991 • 156 citations

Type I transforming growth factor-beta receptors on neutrophils mediate chemotaxis to transforming growth factor-beta.

1991 • 154 citations

Influence of gamma subunit prenylation on association of guanine nucleotide-binding regulatory proteins with membranes.

1992 • 152 citations

Regulation of neutrophil interleukin 8 gene expression and protein secretion by LPS, TNF‐α, and IL‐1β

1993 • 149 citations

Role of microtubule assembly in lysosomal enzyme secretion from human polymorphonuclear leukocytes. A reevaluation.

1977 • 142 citations

In vitro inhibitory effect of IL-8 and other chemoattractants on neutrophil-endothelial adhesive interactions.

1992 • 141 citations

Recombinant interleukin-1 and tumor necrosis factor induce neutrophil migration “in vivo” by indirect mechanisms

1990 • 133 citations

Human recombinant interleukin 1 beta has no effect on intracellular calcium or on functional responses of human neutrophils.

1987 • 131 citations

Effects of hyaluronic acid on the release of proteoglycan from the cell matrix in rabbit chondrocyte cultures in the presence and absence of cytokines

1993 • 115 citations

Expression of IL-1 genes in human and bovine chondrocytes: A mechanism for autocrine control of cartilage matrix degradation

1986 • 113 citations

Antagonistic and agonistic effects of transforming growth factor-beta and IL-1 in rheumatoid synovium.

1990 • 112 citations

Chemoattractant stimulus-response coupling

1992 • 104 citations

Acute and chronic suppression of leukotriene B₄ synthesis EX vivo in neutrophils from patients with rheumatoid arthritis beginning treatment with methotrexate

1992 • 97 citations

In vivo synthesis of IgG by rheumatoid synovium.

1970 • 95 citations

Cytokine regulation of IL-1 beta gene expression in the human polymorphonuclear leukocyte.

1990 • 91 citations

Latent and Active Human Polymorphonuclear Leukocyte Collagenases

1983 • 87 citations

IgG and IgM rheumatoid factor synthesis in rheumatoid synovial membrane cell cultures

1985 • 85 citations

Interleukin-8 primes human neutrophils for enhanced superoxide anion production.

1993 • 85 citations

Interaction of polymorphonuclear leukocytes with immune complexes trapped in rheumatoid articular cartilage

1983 • 77 citations

Degradation of cartilage matrix proteoglycan by human neutrophils involves both elastase and cathepsin G.

1991 • 76 citations

Production of recombinant cytochrome b558 allows reconstitution of the phagocyte NADPH oxidase solely from recombinant proteins

1993 • 76 citations

Interleukin 1, tumor necrosis factor, and interleukin 6 as mediators of cartilage destruction

1989 • 75 citations

Production of cytokines by chondrocytes and its role in proteoglycan degradation.

1991 • 75 citations

Mechanisms of disruption of the articular cartilage surface in inflammation. Neutrophil elastase increases availability of collagen type II epitopes for binding with antibody on the surface of articular cartilage.

1991 • 74 citations

Stimuli which provoke secretion of azurophil enzymes from human neutrophils induce increments in adenosine cyclic 3′-5′-monophosphate

1981 • 73 citations

Antiarthritic drugs containing thiol groups scavenge hypochlorite and inhibit its formation by myeloperoxidase from human leukocytes. A therapeutic mechanism of these drugs in rheumatoid arthritis?

1985 • 73 citations

The relationship between polymorphonuclear granulocytes and cartilage destruction in rheumatoid arthritis.

1978 • 72 citations

Chemoattraction of neutrophils by substance P and transforming growth factor-beta 1 is inadequately explained by current models of lipid remodeling.

1993 • 71 citations

Characterization of a plasma membrane-associated prenylcysteine-directed alpha carboxyl methyltransferase in human neutrophils.

1994 • 71 citations

Nonsteroidal antiinflammatory drugs exert differential effects on neutrophil function and plasma membrane viscosity

1990 • 71 citations

Nitric Oxide Stimulates the ADP-Ribosylation of Actin in Human Neutrophils

1993 • 68 citations

The in vitro effects of methotrexate on peripheral blood mononuclear cells: Modulation by methyl donors and spermidine

1990 • 68 citations

Inhibition of Leukotriene B₄ synthesis in neutrophils from patients with rheumatoid arthritis by a single oral dose of methotrexate

1990 • 67 citations

Scavenger effect of sulfasalazine, 5-aminosalicylic acid, and olsalazine on superoxide radical generation

1991 • 67 citations

Effect of corticosteroid therapy on the phagocytosis of antibody-coated platelets by human leukocytes

1978 • 64 citations

CHANGES IN THE VISCOSITY OF HYALURONIC ACID AFTER EXPOSURE TO A MYELOPEROXIDASE‐DERIVED OXIDANT

1989 • 64 citations

Molecular mechanism of methotrexate action in inflammation

1992 • 62 citations

Granulocyte survival in synovial exudate of patients with rheumatoid arthritis and other inflammatory joint diseases.

1967 • 61 citations

Polymorphonuclear granulocytes in rheumatic tissue destruction

1981 • 56 citations

Collagenase in synovitis of rheumatoid arthritis

1992 • 55 citations

Interaction of polymorphonuclear leukocytes with immune complexes trapped in joint collagenous tissues

1979 • 54 citations

Induction of synthesis and release of interleukin‐8 from human articular chondrocytes and cartilage explants

1992 • 54 citations

Receptor expression in synovial fluid neutrophils from patients with rheumatoid arthritis.

1993 • 53 citations

In vivo leukocyte migration in arthritis

1991 • 52 citations

Postreceptor events associated with human neutrophil activation by interleukin-8

1992 • 50 citations

Recombinant Human Interleukin-1 Beta Primes Human Polymorphonuclear Leukocytes for Stimulus-Induced Myeloperoxidase Release

1990 • 48 citations

Non-steroidal anti-inflammatory drugs: Effects on a GTP binding protein within the neutrophil plasma membrane

1991 • 46 citations

Parallel inhibition of neutrophil arachidonic acid metabolism and lysosomal enzyme secretion by nordihydroguaiaretic acid

1980 • 45 citations

Analysis of function-associated receptor molecules on peripheral blood and synovial fluid granulocytes from patients with rheumatoid and reactive arthritis

1991 • 43 citations

Translocation of p21rac2 from Cytosol to Plasma Membrane Is Neither Necessary nor Sufficient for Neutrophil NADPH Oxidase Activity

1995 • 41 citations

PLASMA LACTOFERRIN AND NEUTROPHIL ELASTASE IN RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS

1990 • 41 citations

The inflammatory role of immune complexes trapped in joint collagenous tissues.

1978 • 40 citations

The effects of IL-1, IL-2, and tumor necrosis factor on polymorphonuclear leukocyte Fc gamma receptor-mediated phagocytosis. IL-2 down-regulates the effect of tumor necrosis factor.

1991 • 39 citations

Effects of high-molecular-weight hyaluronates on the functions of guinea pig polymorphonuclear leukocytes

1993 • 39 citations

Independent induction of interleukin 6 and prostaglandin E2 by interleukin 1 in human articular chondrocytes

1990 • 37 citations

Structure of hyaluronic acid in synovial fluid and its influence on the movement of solutes

1977 • 36 citations

E-selectin (endothelial-leukocyte adhesion molecule-1) is not required for the migration of neutrophils across IL-1-stimulated endothelium in vitro.

1992 • 35 citations

Synthesis of interleukin-1-like activity by normal rat chondrocytes in culture

1988 • 35 citations

Role of polymorphs in inflammatory cartilage destruction in adjuvant arthritis of rats.

1981 • 29 citations

Pharmacology of interleukin-1-induced neutrophil migration

1993 • 28 citations

Recombinant interleukin-1? interacts with high-affinity receptors to activate neutrophil leukotriene B4 synthesis

1990 • 26 citations

Effect of gold sodium thiomalate and its thiomalate component on the in vitro expression of endothelial cell adhesion molecules.

1994 • 25 citations

Impaired polymorphonuclear leucocyte chemotaxis in rheumatoid arthritis.

1984 • 25 citations

Atlas of Blood Cells: Function and Pathology

1989 • 25 citations

Additive enhancement of neutrophil collagenase activity by HOCl and cathepsin G

1992 • 24 citations

Protein synthesis is activated in primed neutrophils: a possible role in inflammation

1987 • 21 citations

Modulation of Arachidonic Acid Metabolism by Olsalazine and Other Aminosalicylates in Leukocytes

1991 • 17 citations

Stimulus—response coupling in neutrophils

1982 • 16 citations

Association of enhanced superoxide generation by neutrophils with low superoxide scavenging activity of the peripheral blood, joint fluid, and their leukocyte components in rheumatoid arthritis: effects of slow-acting anti-rheumatic drugs and disease activity.

1991 • 16 citations

Interleukin-1 modulation of cytokine receptors on human neutrophils: in vitro and in vivo studies

1993 • 16 citations

Effects of sulphasalazine and its metabolites on neutrophil chemotaxis, superoxide production, degranulation and translocation of cytochrome b_‐245

1991 • 14 citations

Impairment of neutrophil Fc gamma receptor mediated transmembrane signalling in active rheumatoid arthritis.

1992 • 14 citations

Cyclic AMP Inhibits Secretion From Electroporated Human Neutrophils

1991 • 13 citations

Differential synthesis of 5-lipoxygenase in peripheral blood and synovial fluid neutrophils in rheumatoid arthritis.

1991 • 12 citations

Interleukin-1 modulation of cytokine receptors on human neutrophils: in vitro and in vivo studies

1993 • 9 citations

Osteoarthritis and hyaluronan—palliative or disease-modifying treatment?

1993 • 9 citations

Inhibition of human neutrophil collagenase by gold(I) salts used in chrysotherapy

1987 • 8 citations

Altered formation of leukotriene B4 in vitro by synovial fluid neutrophils in rheumatoid arthritis.

1989 • 8 citations

Stimulation of Human Polymorphonuclear Leukocytes by Recombinant Human Interleukin-1β

1992 • 6 citations